内吸磷

基本信息
制备方法及用途
物化性质
安全信息
毒理性
MSDS
结构与计算化学

内吸磷基本信息

中文名称：: 内吸磷

中文别名：: 内吸磷;
O,O-二乙基-O-〔2-(乙硫基)乙基〕硫代磷酸酯和O,O-二乙基-S-〔2-(乙硫基)乙基〕硫代磷酸酯混剂;
杀虱多;
一0五九;
一O五九;
1059乳剂

英文名称：: DEMETON

英文别名：: diethoxy-(2-ethylsulfanylethoxy)-sulfanylidene-λ5-phosphane,1-diethoxyphosphorylsulfanyl-2-ethylsulfanylethane;
Systemox;
Demox;
Demeton [BSI];
Caswell No. 279;
Bayer 8169;
Ethyl systox;
Septox;
Systox

CAS No.：: 8065-48-3

分子式：: C16H38O6P2S4

分子量：: 516.68

精确分子量：: 516.10300

PSA：: 190.83000

风险术语：: R27/28; R50

分子结构式：

SDS：: 查看

内吸磷制备方法及用途

制备方法

由硫代磷酰氯与羟基乙硫醚反应而得。

合成制备方法

由硫代磷酰氯与羟基乙硫醚反应而得。

用途简介

主要用来防治棉花和果树的蚜虫和红蜘蛛等刺吸口器害虫,或用涂茎法防治高梁蚜虫。50%乳油3000倍液喷雾,每公顷用量为0.2-0.6kg,可防治棉花蚜虫、红蜘蛛、叶蝉、盲蝽象、蓟马等,也能防治果树蚜虫、红蜘蛛、梨实蜂、柑桔苗木潜叶蛾,药效一般可维持2-4星期。乳油的150-200倍液涂茎可防治高染蚜虫。乳油的10-20倍液包扎树干,可防治柑桔蚜虫、锈壁虱、介壳虫。根据树龄大小一般每株约注入药液100ml。

用途

主要用来防治棉花和果树的蚜虫和红蜘蛛等刺吸口器害虫，或用涂茎法防治高梁蚜虫。50%乳油3000倍液喷雾，每公顷用量为0.2-0.6kg，可防治棉花蚜虫、红蜘蛛、叶蝉、盲蝽象、蓟马等，也能防治果树蚜虫、红蜘蛛、梨实蜂、柑桔苗木潜叶蛾，药效一般可维持2-4星期。乳油的150-200倍液涂茎可防治高染蚜虫。乳油的10-20倍液包扎树干，可防治柑桔蚜虫、锈壁虱、介壳虫。根据树龄大小一般每株约注入药液100ml。

内吸磷物化性质

密度：: 1.143g/cm3
沸点：: 299.6ºC at 760 mmHg
闪点：: 135ºC
折射率：: 1.49
存储条件/存储方法：: 库房通风低温干燥,与食品原料分开储运
稳定性相关：: 1.生产设备必须密闭，车间内保持良好通风状态。操作人员应穿戴劳保用品，注意安全生产。
其它信息：: 1.      性状：淡黄色微溶于水的油状液体，带有硫醇臭味
2.      密度（g/mL 25ºC）：1.117
3.      相对蒸汽密度（g/mL,空气=1）：未确定
4.      熔点（ºC常压）：未确定
5.      沸点（ºC，常压）：116
6.      沸点（ºC,5.2kPa）：未确定
7.      折射率（n20/D）：1.500
8.      闪点（ºC，）：未确定
9.      比旋光度（º）：未确定
10.   自燃点或引燃温度（ºC）：未确定
11.   蒸气压（kPa,25ºC）：0.033
12.   饱和蒸气压（kPa,60ºC）：未确定
13.   燃烧热（KJ/mol）：未确定
14.   临界温度（ºC）：未确定
15.   临界压力（KPa）：未确定
16.   油水（辛醇/水）分配系数的对数值（25℃）：未确定
17.   爆炸上限（%,V/V）：未确定
18.   爆炸下限（%,V/V）：未确定
19.   溶解性(mg/mL) ：在水中溶解度为2000mg/L，能溶于包括万脑油和万油醚在内的多种有机溶剂

内吸磷安全信息

风险类别：: 6.1(a)
危险类别码：: 27/28-50
安全说明：: 28-36/37-45-61
安全标志：: S28:接触皮肤之后，立即使用大量皂液洗涤。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S61:避免排放到环境中。参考专门的说明/安全数据表。
:
危险标志：: T+,N

内吸磷毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TF3150000

CAS REGISTRY NUMBER :: 8065-48-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 66

MOLECULAR FORMULA :: C8-H19-O3-P-S2.C8-H19-O3-P-S2

MOLECULAR WEIGHT :: 516.72

WISWESSER LINE NOTATION :: 2S2OPS&O2&O2 &2S2SPO&O2&O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 171 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 144 mg/kg/24D-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8200 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1750 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7850 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3650 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 15 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 3900 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 8480 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 8480 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 7190 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 1780 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 1800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 10 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - gastrointestinal system Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 10 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 7 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - gastrointestinal system

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,307,1981 *** REVIEWS *** ACGIH TLV-TWA 0.11 mg/m3 (0.01 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued. Volume(issue)/page/year: #73-19,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966- Volume(issue)/page/year: 10(3),43,1975 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.01 ppm (0.1 mg/m3) (skin) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,15,1973 OSHA PEL (Gen Indu):8H TWA 0.1 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.1 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.1 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.1 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.01 ppm (0.1 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 0.01 ppm (0.1 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 0.01 ppm (0.11 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 0.01 ppm (0.1 mg/m3);Skin JAN 1993 OEL-FINLAND:STEL 0.1 ppm (0.3 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 0.01 ppm (0.1 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 0.01 ppm (0.1 mg/m3);Skin JAN 1993 OEL-INDIA:TWA 0.01 ppm (0.1 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.01 ppm (0.1 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.1 mg/m3;Skin JAN 1993 OEL-RUSSIA:STEL 0.02 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.01 ppm (0.1 mg/m3);Skin JAN 1993 OEL-THAILAND:TWA 0.1 mg/m3 JAN 1993 OEL-TURKEY:TWA 0.1 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DEMETON-air:10H TWA 0.1 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

毒理学数据：: 内吸磷为有机磷农药，对雄大鼠口服LD50为30mg/kg(硫酸式)、1.5mg/kg(硫醇式)

内吸磷 MSDS

国标编号:	61874
ＣＡＳ:	8065-48-3
中文名称:	内吸磷
英文名称:	Systox
别名:	一0五九；O,O-二乙基-O-2-乙基硫代乙基硫逐磷酸酯与O,O-二乙基-S-2-乙基硫代乙基硫赶磷酸酯的混合物
分子式:	C₈H₁₉O₃PS₂
分子量:	258
熔点:	116℃/1.07kPa(内吸磷
密度:	1.117(内吸磷)；1.132
蒸汽压:	20℃
溶解性:	在水中溶解度为2000mg/L，能溶于包括万脑油和万油醚在
稳定性:	强碱使其水解
外观与性状:	淡黄色微溶于水的油状液体，带有硫醇臭味。内吸磷为一异构体混合物。市场上出售的药剂含70%的硫酮式酯和30%
危险标记:	13(剧毒品)
用途:	农业上用于防治蚜虫、红蜘蛛、线虫等

2.对环境的影响:

一、健康危害

侵入途径：吸入、食入、经皮吸收。健康危害：本品对健康的危害与一般的有机磷农药相同。中毒情况，早期症状以头晕、无力、倦乏、恶心等居多，少数出现腹痛、呕吐、出汗、肌束颤动等、瞳孔缩小，血压升高，个别严重病例并发中毒性肝炎、阵发性心房颤动以及精神病后遗症等。慢性接触可出现头痛、无力及消化不良，植物神经功能紊乱，部分工人血压偏低等。中毒症状，早期有头晕、无力、恶心、腹痛、出汗、肌束震颤，瞳孔缩小等。严重急性中毒，并可出现中毒性肝炎、陈发性心房纤颤及精神后遗症等。

二、毒理学资料及环境行为

毒性：属高毒类。急性毒性：LD506.0～6.9mg/kg(小鼠经口)；9mg/kg(大鼠经口) 亚急性和慢性毒性：大鼠经口7ppm(慢性喂饲)，胆碱酯酶活性迅速下降。致畸性：小鼠腹腔最小中毒剂量10mg/kg(妊娠期7～11日)致畸胎阳性。

危险特性：遇明火、高热可燃。受高热分解，放出磷、硫的氧化物等毒性气体。燃烧(分解)产物：一氧化碳、二氧化碳、硫化氢、氧化硫、氧化磷。

3.现场应急监测方法:

4.实验室监测方法:

酶-氧化铁比色法《空气中有害物质的测定》(第二版)，杭士平主编气相色谱法《固体废弃物试验分析评价手册》中国环境监测总站等译

5.环境标准:

中国(TJ36-79)	车间空气中有害物质最高容许浓度	0.02mg/m³
^{中国(待颁布)}	^{饮用水源水中有害物质的最高容许浓度}	^0.03mg/L
前苏联	污水中有害物质最高允许浓度	3mg/L

6.应急处理处置方法:

一、泄漏应急处理

疏散泄漏污染区人员至安全区，禁止无关人员进入污染区，切断火源。应急处理人员戴正压自给式呼吸器，穿化学防护服。不要直接接触泄漏物，在确保安全情况下堵漏。用砂土或其它不燃性吸附剂混合吸收，然后收集运至废物处理场所。如大量泄漏，利用围堤收容，然后收集、转移、回收或无害处理后废弃。

二、防护措施

呼吸系统防护：生产操作或农业使用时，必须佩戴防毒口罩。紧急事态抢救或撤离时，佩带自给式呼吸器。眼睛防护：一般不需特殊防护，但建议特殊情况下，戴化学安全防护眼镜。身体防护：穿聚乙烯薄膜防毒服。手防护：戴防化学品手套。其它：皮肤防护也可采用塑料薄膜和涂皂棉布相结合的办法。工作后，淋浴更衣。注意个人清洁卫生。

三、急救措施

皮肤接触：脱去污染的衣着，用肥皂水及清水彻底冲洗。眼睛接触：立即翻开上下眼睑，用流动清水冲洗15分钟。就医。吸入：脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。就医。食入：误服者给饮足量温水，催吐。洗胃。就医。灭火方法：水、干粉、砂土。禁止使用酸碱灭火剂。

内吸磷分子结构与计算化学数据

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:10

4.可旋转化学键数量:18

5.互变异构体数量:无

6.拓扑分子极性表面积171

7.重原子数量:28

8.表面电荷:0

9.复杂度:336

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:2

内吸磷

内吸磷 基本信息

内吸磷 制备方法及用途