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乙二醇单甲醚

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学
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乙二醇单甲醚 基本信息

中文名称：
乙二醇单甲醚 
中文别名：
乙二醇甲醚;
2-甲氧基乙醇;
乙二醇一甲醚;
乙二醇单甲醚;
乙二醇独甲醚;
羟乙基·甲基醚;
甲氧基乙醇 
英文名称：
Ethanol, 2-methoxy-
英文别名：
2-methoxyethanol;
Ethylene glycol monomethyl ether,Methyl glycol;
ethylene glycol monomethyl ether;
H2O;
dowanol7;
glycol monomethyl ether;
Egme;
Ethylene Glycol Monomethyl Ether;
2-Methoxy-aethanol;
SOLVENT S;
WATER G;
MECS;
Ethylene glycol monomethyl ether;
Methyl Cellosolve;
O-Methyl Glycol;
2-Methoxyethanol;
1-hydroxy-2-methoxy-ethane;
EGM;
TAP-WATER;
2-methoxy-ethanol;
Prist;
monoethylene glycol methyl ether;
2-hydroxyethyl methyl ether 
CAS No.：
109-86-4
分 子 式：

C3H8O2

分 子 量：
76.09
精确分子量：
76.05240
PSA：
29.46000
MDL：
MFCD00002867
EINECS：
203-713-7
BRN：
1731074
InChI：
InChI=1/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3
危险品标志：

T:Toxic
 

风险术语：

R10; R20/21/22; R60;

安全术语：

S45; S53;

分子结构式：
SDS：
查看

乙二醇单甲醚 制备方法及用途

制备方法

1.由环氧乙烷与甲醇反应而得。将甲醇加入三氟化硼乙醚络合物中，在搅拌下于25-30℃通入环氧乙烷，通完后温度自动升至38-45℃，将所得反应液用氢氰化钾-甲醇溶液中和至pH=8-9。回收甲醇，蒸馏，收集130℃以前的馏分即得粗品。再进行分馏，收集123-125℃馏分即为成品。工业生产中，将环氧乙烷与无水甲醇在高温高压下反应，不需催化剂，可得高收率的产品。 2.其制备方法是将甲醇加入三氟化硼乙醚配合物中，在搅拌下于25～300℃通入环氧乙烷，通完后温度自动升到38～45℃，所得反应液用氢氧化钾甲醇溶液中和到pH=8～9，回收甲醇，蒸馏，再经分馏得产品。精制方法：易含杂质有水、二甘醇一甲醚(甲基卡必醇)和微量的酸、醛等。实验室的精制方法是用无水碳酸钠干燥后分馏。若有过氧化物存在，可加氯化亚锡回流或将其通过活性氧化铝柱除去。脂肪族酮可加2,4-二硝基苯肼除去。也可用碳酸钾、硫酸钙、硫酸镁或硅胶作干燥剂。3.将含量95%的三级纯乙二醇单甲醚与无水碳酸钠一起振荡，除去无机酸或有机酸杂质，再用无水硫酸钙干燥后蒸馏。

合成制备方法

1.由环氧乙烷与甲醇反应而得。将甲醇加入三氟化硼乙醚络合物中，在搅拌下于25-30℃通入环氧乙烷，通完后温度自动升至38-45℃，将所得反应液用氢氰化钾-甲醇溶液中和至pH=8-9。回收甲醇，蒸馏，收集130℃以前的馏分即得粗品。再进行分馏，收集123-125℃馏分即为成品。

工业生产中，将环氧乙烷与无水甲醇在高温高压下反应，不需催化剂，可得高收率的产品。

2.其制备方法是将甲醇加入三氟化硼乙醚配合物中，在搅拌下于25～300℃通入环氧乙烷，通完后温度自动升到38～45℃，所得反应液用氢氧化钾甲醇溶液中和到pH=8～9，回收甲醇，蒸馏，再经分馏得产品。

精制方法：易含杂质有水、二甘醇一甲醚(甲基卡必醇)和微量的酸、醛等。实验室的精制方法是用无水碳酸钠干燥后分馏。若有过氧化物存在，可加氯化亚锡回流或将其通过活性氧化铝柱除去。脂肪族酮可加2,4-二硝基苯肼除去。也可用碳酸钾、硫酸钙、硫酸镁或硅胶作干燥剂。

3.将含量95%的三级纯乙二醇单甲醚与无水碳酸钠一起振荡，除去无机酸或有机酸杂质，再用无水硫酸钙干燥后蒸馏。

用途简介

用作涂料溶剂、渗透剂、匀染剂及有机合成中间体，也用作喷气燃料的添加剂。

用途

1.本品主要用作油脂、硝化纤维素、合成树脂、醇溶性染料和乙基纤维素的溶剂；涂料工业用作清漆快干剂和涂层稀释剂；印染工业用作渗透剂和匀染剂；燃料工业用作添加剂；纺织工业用于染色助剂以及可作为有机合成中间体。二乙二醇单甲醚主要用作油墨、染料、树脂、纤维素及涂料的高沸点溶剂，加入涂料中能使之易于流动、涂刷和流平，可用作烃的萃取剂，有机合成工业中用于制备酯类衍生物的中间体，以及分析化学中用作化学试剂等。多乙二醇单甲醚可用作刹车液等。

2.用作醇中可溶的染料、油墨、可的松等的溶剂和农药分散剂、皮革处理剂、增塑剂等。

3.广泛用作硝基纤维漆、清漆、瓷漆等涂料的溶剂和稀释剂；胶黏剂的非活性稀释剂；各种油脂类、木质素、硝基纤维素、乙酸纤维素、醇溶性染料、油墨和合成树脂的溶剂以及农药的分散剂、皮革处理剂、增塑剂、光亮剂和有机合成中间体等。

4.用作溶剂。[30]

乙二醇单甲醚 物化性质

外观与性状：
无色透明液体
密度：
998.203±0.01 kg/m3 at 20 °C
熔点：
-85 °C
沸点：
124-125 °C(lit.)
闪点：
115 °F
水溶解性：
SOLUBLE
折射率：
n20/D 1.402(lit.)
蒸汽压：
0.204mmHg at 25°C
蒸汽密度：
2.62 (vs air)
存储条件/存储方法：
库房通风低温干燥,与氧化剂分开存放
稳定性相关：

1.具有醇和醚的化学性质，可与邻苯二甲酸、蓖麻酸、油酸等生成酯。

2.稳定性[25]  稳定

3.禁配物[26]  酰基氯、酸酐、强氧化剂

4.避免接触的条件[27]  空气、光照

5.聚合危害[28]  不聚合

其它信息：

1.性状：无色液体，略有醚的气味。[1]

2.熔点（℃）：-85.1[2]

3.沸点（℃）：124.5[3]

4.相对密度（水=1）：0.97（20℃）[4]

5.相对蒸气密度（空气=1）：2.62[5]

6.饱和蒸气压（kPa）：1.29（25℃）[6]

7.燃烧热（kJ/mol）：-399.5[7]

8.临界温度（℃）：324.45[8]

9.临界压力（MPa）：5.285[9]

10.辛醇/水分配系数：-0.77[10]

11.闪点（℃）：39[11]

12.引燃温度（℃）：285[12]

13.爆炸上限（%）：14[13]

14.爆炸下限（%）：1.8[14]

15.溶解性：与水混溶，可混溶于醇类、酮类、烃类。[15]

16.折射率（n20ºC）：1.4028

17.折射率（n25ºC）：1.4013

18.黏度（mPa·s,20ºC）：1.72

19.黏度（mPa·s,25ºC）：1.60

20.闪点（ºC,闭口）：43

21.闪点（ºC,开口）：461

22.比热容（KJ/(kg·K),25ºC,定压）：2.20

23.电导率（S/m,20ºC）：1.09×10-6

24.蒸气压（kPa,25ºC）：1.3

25.蒸气压（kPa,27ºC）：1.3

26.蒸气压（kPa,56ºC）：6.7

27.体膨胀系数（K-1,20ºC）：0.00095

28.临界密度（g·cm-3）：0.281

29.临界体积（cm3·mol-1）：263

30.临界压缩因子：0.280

31.偏心因子：0.731

32.溶度参数(J·cm-3)0.5：23.204

33.van der Waals面积（cm2·mol-1）：6.880×109

34.van der Waals体积（cm3·mol-1）：45.870

乙二醇单甲醚 安全信息

包装等级：
III
风险类别：
3
海关代码：
2942000000
WGK_Germany：
3
德国有关水污染物质的分类清单
危险类别码：
R10;R20/21/22;R60;R61
安全说明：
S53-S45-S36/37-S16-S26-S23
RTECS号：
ZC0110000
安全标志：
S16:远离火源。
S23:不要吸入蒸汽。
S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S53:避免暴露——使用前先阅读专门的说明。
:
危险标志：
T:Toxic

乙二醇单甲醚 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KL5775000
CHEMICAL NAME :
Ethanol, 2-methoxy-
CAS REGISTRY NUMBER :
109-86-4
BEILSTEIN REFERENCE NO. :
1731074
LAST UPDATED :
199801
DATA ITEMS CITED :
117
MOLECULAR FORMULA :
C3-H8-O2
MOLECULAR WEIGHT :
76.11
WISWESSER LINE NOTATION :
Q2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - guinea pig
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
3380 mg/kg
TOXIC EFFECTS :
Gastrointestinal - gastritis Liver - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
25 ppm
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2370 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 ppm/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2068 mg/kg
TOXIC EFFECTS :
Blood - other hemolysis with or without anemia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2560 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Cardiac - other changes
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1480 ppm/7H
TOXIC EFFECTS :
Behavioral - analgesia Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - hematuria
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2147 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in both tubules and glomeruli Blood - changes in spleen Blood - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
890 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Blood - other hemolysis with or without anemia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
950 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 ppm/6H/2W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10206 mg/kg/21D-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg/10D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight Immunological Including Allergic - decreased immune response
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 ppm/6H/13W-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
970 mg/m3/7H/5W-I
TOXIC EFFECTS :
Blood - changes in bone marrow (not otherwise specified) Blood - changes in spleen
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1000 ppm/6H/11D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in bone marrow (not otherwise specified) Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 gm/kg/4W-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified) Blood - changes in leukocyte (WBC) count Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
450 mg/kg/16D-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
29484 mg/kg/13W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight Blood - changes in platelet count Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3200 mg/kg/4D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight Immunological Including Allergic - decrease in humoral immune response
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12110 mg/kg/2W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
82 gm/kg/13W-C
TOXIC EFFECTS :
Endocrine - effect on menstrual cycle Endocrine - other changes Blood - changes in spleen
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1000 ppm/6H/11D-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
750 ppm/7H/12W-I
TOXIC EFFECTS :
Blood - microcytosis with or without anemia Blood - other changes
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
300 ppm/6H/13W-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight Blood - changes in erythrocyte (RBC) count Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
65 gm/kg/13W-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
175 mg/kg
SEX/DURATION :
female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
175 mg/kg
SEX/DURATION :
female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
15015 mg/kg
SEX/DURATION :
male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
100 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
350 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
68 mg/kg/4H
SEX/DURATION :
female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
30 ppm/6H
SEX/DURATION :
male 65 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
100 ppm/6H
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
100 ppm/6H
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
30 ppm/6H
SEX/DURATION :
male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
11592 mg/kg
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
4375 mg/kg
SEX/DURATION :
male 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
2 gm/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
1 gm/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - gastrointestinal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
330 mg/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
190 mg/kg
SEX/DURATION :
female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
190 mg/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
190 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
600 mg/kg
SEX/DURATION :
female 6-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
440 mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
175 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 gm/kg
SEX/DURATION :
female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6250 mg/kg
SEX/DURATION :
male 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
1000 ppm/6H
SEX/DURATION :
male 11 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
500 ppm/7H
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
50 ppm/6H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
50 ppm/6H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1200 mg/kg
SEX/DURATION :
female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
3200 mg/kg
SEX/DURATION :
female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
250 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
250 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
930 mg/kg
SEX/DURATION :
female 20-45 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
633 mg/kg
SEX/DURATION :
female 20-45 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
300 ppm/6H
SEX/DURATION :
male 65 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
50 ppm/6H
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
50 ppm/6H
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
10 ppm/6H
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6250 mg/kg
SEX/DURATION :
male 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
65 gm/kg
SEX/DURATION :
male 65 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1562 mg/kg
SEX/DURATION :
male 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
Dominant lethal test
TYPE OF TEST :
Sperm Morphology

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 6,390,1984 *** REVIEWS *** ACGIH TLV-TWA 16 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 25 ppm (80 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,158,1971 OSHA PEL (Gen Indu):8H TWA 25 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 25 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 25 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 25 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 25 ppm (80 mg/m3);STEL 40 ppm (120 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (15 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 15 mg/m3;STEL 30 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 25 ppm (80 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 50 mg/m3 JAN 1993 OEL-RUSSIA:TWA 5 ppm JAN 1993 OEL-SWEDEN:TWA 5 ppm (16 mg/m3);STEL 10 ppm (30 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 25 ppm (80 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ETHYLENEGLYCOL MONOMETHYL ETHER-air:10H TWA 0.1 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 46240 No. of Facilities: 11165 (estimated) No. of Industries: 128 No. of Occupations: 102 No. of Employees: 103424 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 46240 No. of Facilities: 8042 (estimated) No. of Industries: 89 No. of Occupations: 86 No. of Employees: 168180 (estimated) No. of Female Employees: 53403 (estimated)
毒理学数据：

1.急性毒性[16]

LD50：2370mg/kg（大鼠经口）；2000mg/kg（兔经皮）

LC50：1500ppm（7h）（大鼠吸入）

2.刺激性[17]

家兔经皮：483mg（24h），轻度刺激。

家兔经眼：500mg（24h），轻度刺激。

3.亚急性与慢性毒性[18]  家兔经口，0.1ml/（kg·d），7d，见暂时性血尿。加大剂量，可致衰竭、震颤、蛋白尿和血尿。尸检见严重肾损害。大鼠暴露于1.05g/m3，每天7h，每周5d，1月后见血液中幼稚白细胞增加。

4.致突变性[19]  显性致死试验：大鼠经口500mg/kg。精子形态学：大鼠经口500mg/kg

5.致畸性[20]  大、小鼠孕后不同时间或多代通过皮下、经口、吸入不同途径给予不同剂量，可致心血管系统、颅面部（包括鼻、舌）、胃肠系统、肌肉骨骼系统、中枢神经系统、泌尿生殖系统、肝胆管系统发育畸形。

6.其他[21]  大鼠经口最低中毒剂量（TDLo）：175mg/kg（孕7~13d），致心血管（循环）系统发育异常。小鼠经口最低中毒剂量（TDLo）：250mg/kg（1d，雄性），影响精子生成（包括遗传物质、精子形态、活动力、计数）

生态数据：

1.生态毒性[22]

LC50：＞10000mg/L（96h）（蓝鳃太阳鱼）；15520mg/L（96h）（虹鳟鱼，一年生）

2.生物降解性[23]

好氧生物降解性（h）：168~672

厌氧生物降解性（h）：672~2688

3.非生物降解性[24]

水中光氧化半衰期（h）：7400~4.70×105

空气中光氧化半衰期（h）：5.7~57

乙二醇单甲醚 MSDS

第一部分：化学品名称

乙二醇单甲醚 分子结构与计算化学数据

分子结构数据

1、摩尔折射率：19.22

2、摩尔体积（cm3/mol）：81.9

3、等张比容（90.2K）：187.9

4、表面张力（dyne/cm）：27.6

5、极化率（10-24cm3）：7.62

计算化学数据

1、疏水参数计算参考值（XlogP）：-0.8

2、氢键供体数量：1

3、氢键受体数量：2

4、可旋转化学键数量：2

5、互变异构体数量：

6、拓扑分子极性表面积（TPSA）：29.5

7、重原子数量：5

8、表面电荷：0

9、复杂度：14.4

10、同位素原子数量：0

11、确定原子立构中心数量：0

12、不确定原子立构中心数量：0

13、确定化学键立构中心数量：0

14、不确定化学键立构中心数量：0

15、共价键单元数量：1

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