脲

外观与性状：

白色结晶粉末

密度：

1.335 g/mL at 25 °C(lit.)

熔点：

132-135 °C(lit.)

沸点：

196.6ºC at 760mmHg

闪点：

72.7ºC

水溶解性：

1080 g/L (20 ºC)

折射率：

n20/D 1.40

存储条件/存储方法：

1.本品应密封于阴凉干燥处保存。

稳定性相关：

1.有一定的吸湿性，加热超过熔点时即分解。

其它信息：

1.        性状：白色、无味、无臭的晶体或粉末

2.        密度（g/mL,25/4℃）：1.323

3.        相对蒸汽密度（g/mL,空气=1）：未确定

4.        熔点（ºC）：132.9℃。加热至熔点以上时分解成缩二脲、氯和三聚氰酸。

5.        沸点（ºC,常压）：383

6.        沸点（ºC,5.2kPa）：未确定

7.        折射率：1.4299

8.        闪点（ºC）：未确定

9.        比旋光度（º）：未确定

10.     自燃点或引燃温度（ºC）：未确定

11.     蒸气压（kPa,25ºC）：未确定

12.     饱和蒸气压（kPa,60ºC）：未确定

13.     燃烧热（KJ/mol）：未确定

14.     临界温度（ºC）：未确定

15.     临界压力（KPa）：未确定

16.    油水（辛醇/水）分配系数的对数值：未确定

17.    爆炸上限（%,V/V）：未确定

18.    爆炸下限（%,V/V）：未确定

19.     溶解性：易溶于水、乙醇和苯，1g该品可溶于1ml、10ml95%乙醇、1ml95%沸乙醇、20ml无水乙醇、6ml甲醇和2ml甘油。微溶于乙醚，不溶于氯仿。

海关代码：

3102100001

WGK_Germany：

1
德国有关水污染物质的分类清单

安全说明：

S26-S36-S24/25

RTECS号：

YR6250000

CHEMICAL IDENTIFICATION

RTECS NUMBER :

YR6250000

CHEMICAL NAME :

Urea

CAS REGISTRY NUMBER :

57-13-6

LAST UPDATED :

199710

DATA ITEMS CITED :

43

MOLECULAR FORMULA :

C-H4-N2-O

MOLECULAR WEIGHT :

60.07

WISWESSER LINE NOTATION :

ZVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Human

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

8471 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

8200 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Behavioral - antipsychotic

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5300 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Behavioral - antipsychotic

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intratracheal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

567 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

11 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

6608 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

9200 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Behavioral - antipsychotic

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

4600 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Behavioral - antipsychotic

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

3 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

3 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

3 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

4800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Bird - pigeon

DOSE/DURATION :

14800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Amphibian - frog

DOSE/DURATION :

600 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - domestic

DOSE/DURATION :

511 mg/kg

TOXIC EFFECTS :

Behavioral - tetany Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

288 mg/m3/17W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes in urine composition Blood - other changes Nutritional and Gross Metabolic - changes in chlorine

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3024 mg/kg/4W-C

TOXIC EFFECTS :

Liver - changes in liver weight Endocrine - changes in thymus weight Related to Chronic Data - changes in testicular weight

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

37800 mg/kg/25W-C

TOXIC EFFECTS :

Brain and Coverings - changes in brain weight Related to Chronic Data - changes in prostate weight

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

821 gm/kg/1Y-C

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria Blood - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

394 gm/kg/1Y-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraplacental

DOSE :

1400 mg/kg

SEX/DURATION :

female 16 week(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - abortion

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraplacental

DOSE :

1600 mg/kg

SEX/DURATION :

female 16 week(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - abortion

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraplacental

DOSE :

1600 mg/kg

SEX/DURATION :

female 16 week(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - abortion

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intrauterine

DOSE :

6 gm/kg

SEX/DURATION :

female 18 week(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - abortion

TYPE OF TEST :

Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :

Cytogenetic analysis

TEST SYSTEM :

Rodent - hamster Lung

DOSE/DURATION :

13 gm/L

REFERENCE :

GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80231 No. of Facilities: 22367 (estimated) No. of Industries: 156 No. of Occupations: 119 No. of Employees: 284911 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7915 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 63 (estimated) No. of Female Employees: 9 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80231 No. of Facilities: 31269 (estimated) No. of Industries: 204 No. of Occupations: 164 No. of Employees: 783504 (estimated) No. of Female Employees: 326824 (estimated)

分子结构数据

1、   摩尔折射率：13.78

2、   摩尔体积（cm³/mol）：49.5

3、   等张比容（90.2K）：135.0

4、   表面张力（dyne/cm）：55.3

5、   极化率（10^-24cm³）：5.46

计算化学数据

1.疏水参数计算参考值（XlogP）:-1.4

2.氢键供体数量:2

3.氢键受体数量:1

4.可旋转化学键数量:0

5.互变异构体数量:2

6.拓扑分子极性表面积69.1

7.重原子数量:4

8.表面电荷:0

9.复杂度:29

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  尿素红外图谱(IR1)
• 
  尿素红外图谱(IR2)
• 
  尿素质谱(MS)
• 
  尿素Raman光谱
• 
  尿素核磁图(¹HNMR)