N-乙酰对氨基酚

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学
  • 下游产品
  • 表征图谱

N-乙酰对氨基酚 基本信息

中文名称:
N-乙酰对氨基酚 
中文别名:
N-乙酰对氨基酚;
N-(4-羟基苯基)乙酰胺;
对乙酰氨基酚,N-(4-羟基苯基)乙酰胺,对羟基乙酰苯胺;
4'-羟基乙酰苯胺;
扑热息痛;
4-乙酰氨基酚;
4-乙酰胺基苯酚;
对乙酰氨基苯酚;
对乙酰氨基酚 
英文名称:
4-acetaminophenol
英文别名:
paracetamol;
Korum;
Fevor;
APAP;
4-Acetamidophenol;
Paracetamol;
N-(4-Hydroxyphenyl)acetamide;
Acetaminophen;
Dirox;
4'-Hydroxyacetanilide;
Dypap;
Exdol;
G 1;
Panex;
Hedex;
NAPAP 
CAS No.:
103-90-2
分 子 式:

C8H9NO2

分 子 量:
151.16
精确分子量:
151.06300
PSA:
49.33000
MDL:
MFCD00002328
EINECS:
203-157-5
BRN:
2208089
InChI:
InChI=1/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)/i2D,3D,4D,5D
危险品标志:

HarmfulXn;

风险术语:

R22;R52/53

安全术语:

S61

分子结构式:
SDS:
查看

N-乙酰对氨基酚 制备方法及用途

制备方法

对氨基酚乙酰化而得。方法1:将对氨基酚加入稀乙酸中,再加入冰醋酸,升温至150℃反应7h,加入乙酐,再反应2h,检查终点,合格后冷却至25℃以下,甩滤,水洗至无乙酸味,甩干,得粗品。方法2:将对氨基酚、冰醋酸及含酸50%以上的酸母液一起蒸馏,蒸出稀酸的速度为每小时馏出总量的十分之一,待内温升至130℃以上,取样检查对氨基酚残留量低于2.5%,加入稀酸(含量50%以上),冷却结晶。甩滤,先用少量稀酸洗涤,再用大量水洗至滤液接近无色,得粗品。方法1的收率为90%,方法2的收率为90-95%。精制方法:将水加热至近沸时投入粗品。升温至全溶,加入用水浸泡过的活性炭,用稀乙酸调节至pH=4.2-4.6,沸腾10min。压滤,滤液加少量重亚硫酸钠。冷却至20℃以下,析出结晶。甩滤,水洗,干燥得原料药扑热息痛成品。其他的生产方法还有:(1)在冰醋酸中用锌还原对硝基苯酚,同时乙酰化得到对乙酰氨基酚;(2)将对羟基苯乙酮生成的腙,置于硫酸酸性溶液中,加入亚硝酸钠,转位生成对乙酰氨基酚。

合成制备方法

对氨基酚乙酰化而得。方法1:将对氨基酚加入稀乙酸中,再加入冰醋酸,升温至150℃反应7h,加入乙酐,再反应2h,检查终点,合格后冷却至25℃以下,甩滤,水洗至无乙酸味,甩干,得粗品。方法2:将对氨基酚、冰醋酸及含酸50%以上的酸母液一起蒸馏,蒸出稀酸的速度为每小时馏出总量的十分之一,待内温升至130℃以上,取样检查对氨基酚残留量低于2.5%,加入稀酸(含量50%以上),冷却结晶。甩滤,先用少量稀酸洗涤,再用大量水洗至滤液接近无色,得粗品。方法1的收率为90%,方法2的收率为90-95%。精制方法:将水加热至近沸时投入粗品。升温至全溶,加入用水浸泡过的活性炭,用稀乙酸调节至pH=4.2-4.6,沸腾10min。压滤,滤液加少量重亚硫酸钠。冷却至20℃以下,析出结晶。甩滤,水洗,干燥得原料药扑热息痛成品。其他的生产方法还有:(1)在冰醋酸中用锌还原对硝基苯酚,同时乙酰化得到对乙酰氨基酚;(2)将对羟基苯乙酮生成的腙,置于硫酸酸性溶液中,加入亚硝酸钠,转位生成对乙酰氨基酚。

用途简介

解热镇痛药。

用途

1.药物中间体。制造偶氮染料。照相化学药品。

N-乙酰对氨基酚 物化性质

密度:
1,293 g/cm3
熔点:
168-172 °C(lit.)
水溶解性:
14 g/L (20 ºC)
存储条件/存储方法:

1.储存于阴凉、通风的库房。远离火种、热源。保持容器密封。应与氧化剂分开存放,切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。
稳定性相关:

1.避免与氧化物接触。

2.有毒,具有刺激性,使用时应避免与眼睛及皮肤接触。

其它信息:

1.       性状:无色单斜方棱形式结晶。无臭。味苦。

2.       密度(g/mL,25/4℃): 1.293

3.       相对蒸汽密度(g/mL,空气=1):未确定

4.       熔点(ºC):169-170

5.       沸点(ºC,常压):未确定

6.       沸点(ºC,5.2kPa):未确定

7.       折射率:未确定

8.       闪点(ºC):未确定

9.       比旋光度(º):未确定

10.    自燃点或引燃温度(ºC):未确定

11.    蒸气压(kPa,25ºC):未确定

12.    饱和蒸气压(kPa,60ºC):未确定

13.    燃烧热(KJ/mol):未确定

14.    临界温度(ºC):未确定

15.    临界压力(KPa):未确定

16.    油水(辛醇/水)分配系数的对数值:未确定

17.    爆炸上限(%,V/V):未确定

18.    爆炸下限(%,V/V):未确定

19.溶解性:溶于甲醇、乙醇、二氯乙烯、丙酮和乙酸乙酯,微溶于乙醚和热水,几乎不溶于冷水,不溶于石油醚、戊烷和苯。

N-乙酰对氨基酚 安全信息

海关代码:
29242930
WGK_Germany:
1
德国有关水污染物质的分类清单
危险类别码:
R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . R36/38:Irritating to eyes and skin . R40:Limited evidence of a carc
安全说明:
S26-S36-S61-S37/39
RTECS号:
AE4200000
安全标志:
S26:万一接触眼睛,立即使用大量清水冲洗并送医诊治。
S36:穿戴合适的防护服装。
危险标志:
Xn

N-乙酰对氨基酚 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AE4200000
CHEMICAL NAME :
Acetanilide, 4'-hydroxy-
CAS REGISTRY NUMBER :
103-90-2
BEILSTEIN REFERENCE NO. :
2208089
LAST UPDATED :
199806
DATA ITEMS CITED :
92
MOLECULAR FORMULA :
C8-H9-N-O2
MOLECULAR WEIGHT :
151.18
WISWESSER LINE NOTATION :
QR DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
591 mg/kg/2D-I
TOXIC EFFECTS :
Liver - liver function tests impaired Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - aplastic anemia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
4962 ug/kg
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of endocrine pancreas Liver - liver function tests impaired Blood - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
714 mg/kg
TOXIC EFFECTS :
Liver - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
1440 mg/kg/6D
TOXIC EFFECTS :
Behavioral - irritability Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature increase
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
143 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
360 mg/kg/2D
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Liver - other changes Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
801 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Gastrointestinal - nausea or vomiting Liver - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
714 mg/kg
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
357 mg/kg
TOXIC EFFECTS :
Behavioral - anorexia (human) Behavioral - coma Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
260 mg/kg
TOXIC EFFECTS :
Behavioral - coma Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
490 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
143 mg/kg/24H-I
TOXIC EFFECTS :
Behavioral - anorexia (human) Liver - hepatitis (hepatocellular necrosis), zonal Liver - jaundice, other or unclassified
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
650 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section Vascular - other changes Nutritional and Gross Metabolic - metabolic acidosis
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Cardiac - other changes Lungs, Thorax, or Respiration - acute pulmonary edema Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Behavioral - coma Liver - liver function tests impaired Nutritional and Gross Metabolic - metabolic alkalosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1944 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1205 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
338 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
367 mg/kg
TOXIC EFFECTS :
Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Blood - changes in spleen Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
826 mg/kg
TOXIC EFFECTS :
Behavioral - analgesia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2620 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - tremor
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
512 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
891 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
105 gm/kg/35D-C
TOXIC EFFECTS :
Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
68 gm/kg/13W-C
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6080 mg/kg/19D-I
TOXIC EFFECTS :
Gastrointestinal - other changes Liver - changes in liver weight Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1600 mg/kg/2D-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
136 gm/kg/13W-C
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
336 gm/kg/40W-C
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse Liver - other changes Liver - changes in liver weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
164 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
135 gm/kg/77W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - hepatitis (hepatocellular necrosis), zonal Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
270 gm/kg/77W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Endocrine - other changes
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
329 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
650 mg/kg
SEX/DURATION :
female 29 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - Apgar score (human only) Reproductive - Effects on Newborn - other neonatal measures or effects Reproductive - Effects on Newborn - other postnatal measures or effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
417 mg/kg
SEX/DURATION :
female 20 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - hepatobiliary system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1300 mg/kg
SEX/DURATION :
female 31-32 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Effects on Newborn - other neonatal measures or effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1500 mg/kg
SEX/DURATION :
female 8-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
12500 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating female 1-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 gm/kg
SEX/DURATION :
female 3 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - other postnatal measures or effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
35 gm/kg
SEX/DURATION :
male 70 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
25 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
600 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2500 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2500 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 gm/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Sister chromatid exchange
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
DNA damage
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Sister chromatid exchange
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
1 mmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,51,1988 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,307,1990 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,307,1990 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,307,1990 TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 TOXICOLOGY REVIEW AUHPAI Australian Journal of Hospital Pharmacy. (B.R. Miller, POB 125, Heidelberg, Vic., Australia) V.1- 1971- Volume(issue)/page/year: 3(3),100,1973 TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 12,601,1978 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB282-666 TOXICOLOGY REVIEW OBGNAS Obstetrics and Gynecology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1953- Volume(issue)/page/year: 58,57S,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80396 No. of Facilities: 1829 (estimated) No. of Industries: 7 No. of Occupations: 14 No. of Employees: 9269 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80396 No. of Facilities: 1261 (estimated) No. of Industries: 7 No. of Occupations: 26 No. of Employees: 65107 (estimated) No. of Female Employees: 56260 (estimated)
毒理学数据:

半数致死量(大鼠,经口)338 mg/kg.

生态数据:

对水是极其危害的,对鱼类有毒性,切勿让产品进入水体。

N-乙酰对氨基酚 MSDS

  4'-羟基乙酰苯胺      修改号码:6    

模块 1. 化学品
    产品名称:      4'-Hydroxyacetanilide    
    修改号码:      6    

模块 2. 危险性概述
  GHS分类
     物理性危害        未分类    
     健康危害
    急性毒性(经口)      第4级    
    生殖细胞敏感性      第2级    
    特异性靶器官毒性      肝脏, 消化道, 心脏, 肾脏, 中枢神经系统    
  - 单一接触 [第1级]
    特异性靶器官毒性      呼吸系统, 睾丸    
  - 单一接触 [第2级]
    特异性靶器官毒性      肝脏, 血液(系统), 肾脏    
  - 单一接触 [第1级]
    特异性靶器官毒性        甲状腺    
  - 单一接触 [第2级]
     环境危害
    急性水生毒性      第2级    
    慢性水生毒性      第2级    
  GHS标签元素
     图标或危害标志
     信号词        危险    
     危险描述        吞咽有害。    
    怀疑会造成遗传缺陷
    对器官引起损害: 肝脏 消化道 心脏 肾脏 中枢神经系统
    可能对器官产生损害: 呼吸系统 睾丸
    可能因延长或接触对器官产生损害: 肝脏 血液(系统) 肾
    脏
    可能因延长或接触对器官产生损害: 甲状腺
  4'-羟基乙酰苯胺      修改号码:6    

模块 2. 危险性概述
    对水生生物有毒性
    长期影响对水生生物有毒性
     防范说明
  [预防]        使用前获取特定手册。    
    处理前必须阅读并理解所有安全措施。
    切勿吸入。
    避免释放到环境中。
    使用本产品时切勿吃东西,喝水或吸烟。
    处理后要彻底清洗双手。
    使用个人所需的防护用具。
  [急救措施]      食入:若感不适,呼叫解毒中心/医生。漱口。    
  如接触到或相关接触:求医/就诊。
    收集溢出物。
  [储存]        存放处须加锁。    
  [废弃处置]      根据当地政府规定把物品/容器交与工业废弃处理机构。    

模块 3. 成分/组成信息
  单一物质/混和物        单一物质    
  化学名(中文名):      4'-羟基乙酰苯胺    
    百分比:      >98.0%(HPLC)(N)    
  CAS编码:      103-90-2    
    俗名:      4-Acetamidophenol , Acetaminophen , Paracetamol    
    分子式:      C8H9NO2    

模块 4. 急救措施
    吸入:      将受害者移到新鲜空气处,保持呼吸通畅,休息。求医/就诊。    
    皮肤接触:      立即去除/脱掉所有被污染的衣物。用大量肥皂和水轻轻洗。    
  求医/就诊。
    眼睛接触:        用水小心清洗几分钟。如果方便,易操作,摘除隐形眼镜。    
  求医/就诊。
    食入:      求医/就诊。漱口。    
    危害迹象:      腹痛, 腹泻, 嗜睡, 恶心, 意识丧失, 呕吐    
    紧急救助者的防护:        救援者需要穿戴个人防护用品,比如橡胶手套和气密性护目镜。    
    医生注意事项:        建议医学观察。    

模块 5. 消防措施
    合适的灭火剂:        干粉,泡沫,雾状水,二氧化碳    
    特殊危险性:        小心,燃烧或高温下可能分解产生毒烟。    
    特定方法:        从上风处灭火,根据周围环境选择合适的灭火方法。    
    非相关人员应该撤离至安全地方。
    周围一旦着火:如果安全,移去可移动容器。
    消防员的特殊防护用具:        灭火时,一定要穿戴个人防护用品。    

模块 6. 泄漏应急处理
    个人防护措施,防护用具,      使用特殊的个人防护用品(针对有毒颗粒的P3过滤式空气呼吸器)。远离溢出物/泄露    
    紧急措施:        处并处在上风处。    
    泄露区应该用安全带等圈起来,控制非相关人员进入。
    环保措施:        小心,切勿排入河流等。因为考虑对环境有负面影响。    
  4'-羟基乙酰苯胺      修改号码:6    

模块 6. 泄漏应急处理
    控制和清洗的方法和材料:        清扫收集粉尘,封入密闭容器。注意切勿分散。附着物或收集物应该立即根据合适的    
    法律法规处置。

模块 7. 操作处置与储存
    处理
    技术措施:        在通风良好处进行处理。穿戴合适的防护用具。防止粉尘扩散。处理后彻底清洗双手    
    和脸。
    注意事项:        如果可能,使用封闭系统。如果粉尘或浮质产生,使用局部排气。    
    操作处置注意事项:        避免所有部位的接触!    
    贮存
    储存条件:        保持容器密闭。存放于凉爽、阴暗处。    
    存放处须加锁。
    远离不相容的材料比如氧化剂存放。
    包装材料:        依据法律。    

模块 8. 接触控制和个体防护
    工程控制:        尽可能安装封闭体系或局部排风系统。同时安装淋浴器和洗眼器。    
    个人防护用品
     呼吸系统防护:      防尘面具,自携式呼吸器(SCBA),供气呼吸器等。使用通过政府标准的呼吸器。依    
    据当地和政府法规。
     手部防护:        防渗手套。    
     眼睛防护:        护目镜。如果情况需要,佩戴面具。    
     皮肤和身体防护:        防渗防护服。如果情况需要,穿戴防护靴。    

模块 9. 理化特性
    固体
  外形(20°C):
    外观:      晶体-粉末    
    颜色:        白色类白色    
    气味:        无味    
  pH:      5.5 - 6.5 (saturated soln.H2O)    
    熔点:
  169°C
  沸点/沸程        无资料    
    闪点:        无资料    
    爆炸特性
     爆炸下限:        无资料    
     爆炸上限:        无资料    
    蒸气压:      9.3x10-4Pa/25°C    
    密度:        无资料    
    溶解度:
  [水]      微溶于(1.4g/100mL, 20°C)    
  [其他溶剂]
    溶于:      丙酮, 乙醇, 二甲基甲酰胺, 乙酸乙酯    
    微溶于:        醚    
    不溶于:      苯, 石油醚    
  log水分配系数 =      0.49    

模块 10. 稳定性和反应性
    化学稳定性:        一般情况下稳定。    
    危险反应的可能性:        未报道特殊反应性。    
  4'-羟基乙酰苯胺      修改号码:6    

模块 10. 稳定性和反应性
    须避免接触的物质        氧化剂    
  危险的分解产物:      一氧化碳, 二氧化碳, 氮氧化物 (NOx)    

模块 11. 毒理学信息
    急性毒性:      orl-rat LD50:1944 mg/kg    
  scu-mus LD50:310 mg/kg
  ipr-rat LD50:1205 mg/kg
  orl-hmn LDLo:143 mg/kg
    对皮肤腐蚀或刺激:        无资料    
    对眼睛严重损害或刺激:        无资料    
    生殖细胞变异原性:      cyt-hmn-lym 200 mg/L    
  cyt-hmn-orl 42860 ug/kg
  dns-rat-orl 500 mg/kg
  mmo-sat 100 ug/disc (+S9)
    致癌性:      orl-mus TDLo:135 g/kg/77W-C    
  orl-rat TDLo:164 g/kg/78W-C
  IARC =      3 (无法对人类的致癌性进行分类)。    
  NTP =        无资料    
    生殖毒性:        无资料    
  RTECS 号码:      AE4200000    

模块 12. 生态学信息
    生态毒性:
    鱼类:      96h LC50:>100 mg/L (Oryzias latipes)    
    甲壳类:      48h EC50:3.5 mg/L (Daphnia magna)    
    藻类:      72h EC50:150 mg/L (Selenastrum capricornutum)    
  残留性 / 降解性:        无资料    
  潜在生物累积 (BCF):        无资料    
    土壤中移动性
   log水分配系数:      0.49    
   土壤吸收系数 (Koc):        无资料    
     亨利定律        无资料    
  constant(PaM3/mol):

模块 13. 废弃处置
    如果可能,回收处理。请咨询当地管理部门。建议在可燃溶剂中溶解混合,在装有后燃和洗涤装置的化学焚烧炉中
    焚烧。废弃处置时请遵守国家、地区和当地的所有法规。

模块 14. 运输信息
    联合国分类:      第9类 杂类    
  UN编号:      3077    
    正式运输名称:      环境有害物质, 固体, 不另作详细说明    
    包装等级:      III    
  海洋污染物:      Y    

模块 15. 法规信息
  《危险化学品安全管理条例》(2002年1月26日国务院发布,2011年2月16日修订): 针对危险化学品的安全使用、
    生产、储存、运输、装卸等方面均作了相应的规定。
  4'-羟基乙酰苯胺      修改号码:6    


模块16 - 其他信息
N/A

N-乙酰对氨基酚 分子结构与计算化学数据

分子结构数据

1、   摩尔折射率:42.40

2、   摩尔体积(cm3/mol):120.9

3、   等张比容(90.2K):326.0

4、   表面张力(dyne/cm):52.8

5、   介电常数:

6、   偶极距(10-24cm3):

7、   极化率:16.81

计算化学数据

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:2

3.氢键受体数量:2

4.可旋转化学键数量:1

5.互变异构体数量:6

6.拓扑分子极性表面积49.3

7.重原子数量:11

8.表面电荷:0

9.复杂度:139

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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