二氯丙烷

外观与性状：

无色液体,带有特有的气味

密度：

1.156 g/mL at 25 °C(lit.)

熔点：

−100 °C(lit.)

沸点：

95-96 °C(lit.)

闪点：

40 °F

水溶解性：

3 g/L (20 ºC)

折射率：

n20/D 1.439(lit.)

蒸汽密度：

3.89 (vs air)

存储条件/存储方法：

库房通风低温干燥,与氧化剂、酸类分开存放

稳定性相关：

    其蒸气与空气形成爆炸性混合物，遇明火、高热能引起燃烧爆炸，爆炸极限3.4~14.5（体积）受高热分解产生有毒的腐蚀性气体。 

其它信息：

1.       性状：无色液体，有氯仿的气味。

2.       沸点（ºC）：95~96

3.       熔点（ºC）：-100

4.       相对密度（g/mL,20ºC）：1.156

5.       相对蒸汽密度（g/mL,空气=1）：3.9

6.       折射率：1.4388

7.       黏度（mPa·s,20ºC）：0.865

8.       闪点（ºC）：4

9.       燃点（ºC）：557.2

10.    蒸发热（KJ/kg,b.p.）：323.2

11.    熔化热（KJ/kg）：56.6

12.    燃烧热（KJ/mol）：1545.4

13.    比热容（KJ/(kg·K),20ºC）：1.30

14.    临界温度（ºC）：304.3

15.    临界压力（MPa）：4.4

16.    蒸气压（kPa,20ºC）：5.33

17.    爆炸下限（%,V/V）：3.4

18.    爆炸上限（%,V/V）：14.5

19.    体膨胀系数（K^-1,20ºC）：0.001108

20.    溶解性：不溶于水，能与乙醇、乙醚、苯、四氯化碳等大多数有机溶剂混溶。能溶解油脂、蜡、橡胶、树脂及多种染料。20℃时在水中的溶解度为0.26%。

21.    溶度参数(J·cm^-3)^0.5：18.395

22.    van der Waals面积（cm²·mol^-1）：7.640×10⁹

23.    van der Waals体积（cm³·mol^-1）：54.540

24.    气相标准声称热(焓)( kJ·mol^-1) ：-162.8

25.    液相标准声称热(焓)( kJ·mol^-1)：-198.8

26.    液相标准热熔(J·mol^-1·K^-1)：145.8

包装等级：

II

风险类别：

3

海关代码：

2903199000

WGK_Germany：

3
德国有关水污染物质的分类清单

危险类别码：

R11;R20/22

安全说明：

S16-S24-S45-S36/37-S7

RTECS号：

TX9625000

安全标志：

S16:远离火源。
S24:避免接触皮肤。

危险标志：

F:Flammable

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TX9625000

CHEMICAL NAME :

Propane, 1,2-dichloro-

CAS REGISTRY NUMBER :

78-87-5

BEILSTEIN REFERENCE NO. :

1718880

LAST UPDATED :

199712

DATA ITEMS CITED :

72

MOLECULAR FORMULA :

C3-H6-Cl2

MOLECULAR WEIGHT :

112.99

WISWESSER LINE NOTATION :

GY1&1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1947 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

14 gm/m3/8H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1100 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

860 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1000 ppm/2H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

960 mg/kg

TOXIC EFFECTS :

Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

5 gm/kg

TOXIC EFFECTS :

Behavioral - sleep Liver - other changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

8750 uL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

28 gm/kg/14D-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

109 mg/kg/26W-I

TOXIC EFFECTS :

Gastrointestinal - changes in structure or function of endocrine pancreas Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other hydrolases

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

16250 mg/kg/13W-I

TOXIC EFFECTS :

Liver - changes in liver weight Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

9 mg/m3/24H/94D-C

TOXIC EFFECTS :

Brain and Coverings - recordings from specific areas of CNS Lungs, Thorax, or Respiration - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

10 mg/m3/24H/60D-I

TOXIC EFFECTS :

Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1000 ppm/7H/20W-I

TOXIC EFFECTS :

Liver - fatty liver degeneration Blood - changes in spleen Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2500 mg/kg/5D-I

TOXIC EFFECTS :

Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1400 mg/kg/4W-I

TOXIC EFFECTS :

Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

28 gm/kg/14D-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

32500 mg/kg/13W-I

TOXIC EFFECTS :

Related to Chronic Data - death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

400 ppm/7H/7W-I

TOXIC EFFECTS :

Liver - fatty liver degeneration Related to Chronic Data - death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

1000 ppm/7H/26W-I

TOXIC EFFECTS :

Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine - other changes

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

1500 ppm/7H/8W-I

TOXIC EFFECTS :

Liver - fatty liver degeneration Endocrine - other changes Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

130 gm/kg/2Y-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1250 mg/kg

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1950 mg/kg

SEX/DURATION :

female 7-19 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects

MUTATION DATA

TYPE OF TEST :

Sister chromatid exchange

TEST SYSTEM :

Rodent - hamster Lung

REFERENCE :

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 508 mg/m3 (110 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 347 mg/m3 (75 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,131,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,131,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949- Volume(issue)/page/year: 4,1,1952 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 75 ppm (350 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,218,1971 OSHA PEL (Gen Indu):8H TWA 75 ppm (350 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 75 ppm (350 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 75 ppm (350 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 75 ppm (350 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 75 ppm (350 mg/m3);STEL 110 ppm (510 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 75 ppm (350 mg/m3) JAN 1993 OEL-BELGIUM:TWA 75 ppm (347 mg/m3);STEL 110 ppm (509 mg/m3) JAN 1993 OEL-DENMARK:TWA 75 ppm (350 mg/m3) JAN 1993 OEL-FINLAND:TWA 75 ppm (350 mg/m3);STEL 115 ppm (530 mg/m3) JAN 1993 OEL-FRANCE:TWA 75 ppm (350 mg/m3) JAN 1993 OEL-GERMANY:TWA 75 ppm (350 mg/m3) JAN 1993 OEL-HUNGARY:TWA 50 mg/m3;STEL 100 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 75 ppm (350 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 75 ppm (350 mg/m3) JAN 1993 OEL-POLAND:TWA 50 mg/m3 JAN 1993 OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 75 ppm (350 mg/m3);STEL 375 ppm (1750 mg/m3) JAN 1993 OEL-TURKEY:TWA 74 ppm (350 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PROPYLENE DICHLORIDE-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 24390 No. of Facilities: 653 (estimated) No. of Industries: 13 No. of Occupations: 15 No. of Employees: 9601 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 24390 No. of Facilities: 116 (estimated) No. of Industries: 6 No. of Occupations: 15 No. of Employees: 2944 (estimated) No. of Female Employees: 1022 (estimated)

毒理学数据：

能刺激眼睛、黏膜，引起皮肤炎。高浓度对中枢神经系统有抑制作用。并损害肝、肾脏。嗅觉阈浓度231mg/m3，工作场所最高容许浓度350mg/m3（美国）。小鼠经口LD50为860mg/kg，大鼠吸入的致死浓度为9240mg/m3。

中国海关编码：2903199000

概述：

2903199000 其他无环烃的饱和氯化衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

申报要素：

品名, 成分含量, 用途

摘要/Summary：

2903199000 other saturated chlorinated derivatives of acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

分子结构数据

1、   摩尔折射率：25.60

2、   摩尔体积（cm³/mol）：101.2

3、   等张比容（90.2K）：225.7

4、   表面张力（dyne/cm）：24.7

5、   极化率（10^-24cm³）：10.15

计算化学数据

1.疏水参数计算参考值（XlogP）:1.8

2.氢键供体数量:0

3.氢键受体数量:0

4.可旋转化学键数量:1

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:5

8.表面电荷:0

9.复杂度:20.9

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:1

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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  2-二氯丙烷红外图谱(IR1)
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  1
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  2-二氯丙烷红外图谱(IR2)
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  1
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  2-二氯丙烷质谱(MS)