奥昔啡烷

  • 基本信息
  • 物化性质
  • 毒理性

奥昔啡烷 基本信息

中文名称:
奥昔啡烷 
中文别名:
奥昔啡烷 
英文名称:
Morphinan-3,14-diol,17-(cyclopropylmethyl)-
英文别名:
Oxilorphan;
(L)-BC-2605;
Oxilorfano [INN-Spanish];
Levo-BC-2605;
Bristol laboratories BC 2605;
(-)-17-Cyclopropylmethylmorphinan-3,4-diol;
3,14-dihydroxy-N-cyclopropylmethylmorphinan;
EINECS 255-749-8 
CAS No.:
42281-59-4
分 子 式:
C20H27NO2
分 子 量:
313.48
精确分子量:
313.20400
PSA:
43.70000
EINECS:
255-749-8
InChI:
The Key: STBZIDOIKQNFCQ-HSALFYBXSA-N
安全术语:
Poison by subcutaneous and intravenous routes. Human systemic effects by ingestion and subcutaneous routes: somnolence, tremors, ataxia (loss of muscle coordination), hypermotility, diarrhea, and changes in the kidney, ureter, or bladder. When heated to decomposition it emits toxic fumes of NOx.
分子结构式:
SDS:
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奥昔啡烷 物化性质

密度:
1.27g/cm3
沸点:
495.4ºC at 760mmHg
闪点:
262.9ºC
折射率:
1.653

奥昔啡烷 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QC7800000
CHEMICAL NAME :
Morphinan-3,14-diol, 17-(cyclopropylmethyl)-
CAS REGISTRY NUMBER :
42281-59-4
LAST UPDATED :
199009
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H27-N-O2
MOLECULAR WEIGHT :
313.48
WISWESSER LINE NOTATION :
T6 G666/FQ 2AF Q FX ONT&TTJ AQ IQ O1- AL3TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
14 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - other changes
REFERENCE :
JCPCBR Journal of Clinical Pharmacology. (Hall Assoc., PO Box 482, Stamford, CT 06904) V.13- 1973- Volume(issue)/page/year: 16,183,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Human
DOSE/DURATION :
26 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,746,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
315 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 193,23,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 193,23,1975

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