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胍乙啶
- 基本信息
- 制备方法及用途
- 物化性质
- 毒理性
- 上游产品
胍乙啶 基本信息
- 中文名称:
- 胍乙啶
- 中文别名:
- 依斯美林;
胍乙啶
- 英文名称:
- Guanidine,N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-
- 英文别名:
- guanethidine;
Guanethidinum;
Octadine;
GUANETHIDINE;
(2--ethyl)-guanidin;
Oktadin;
[2-(hexahydro-1-(2H)-azocinyl)ethyl]guanidine;
Isobarin;
Sanotensin;
2-[2-(azocan-1-yl)ethyl]guanidine;
Oktatenzin;
(2-azocan-1-yl-ethyl)-guanidine;
Ismelin;
Eutensol;
guanethedine;
Abapresin
- CAS No.:
- 55-65-2
- 分 子 式:
- C10H22N4
- 分 子 量:
- 198.30848
- 精确分子量:
- 198.18400
- PSA:
- 65.14000
- EINECS:
- 200-241-3
- InChI:
- The Key: ACGDKVXYNVEAGU-UHFFFAOYSA-N
- 分子结构式:
-
- SDS:
- 查看
胍乙啶 制备方法及用途
制备方法
由环庚亚胺(见C7H5N,[1121-92-2])与邻苯二甲酰溴乙亚胺缩合后水解,得到N-氨乙基环庚亚胺,再与异甲硫脲硫酸盐缩合即得胍乙啶硫酸盐。将环庚亚胺配制成二甲苯溶液,与邻苯二甲酰溴乙亚胺在反应锅内混合。先加入1/3量的碳酸钠,加热蒸去水份,待温度升至138℃回流1h后,降温。加入1/3量的碳酸钠,再蒸去水分,回流2h,加入其余1/3量的碳酸钠,蒸去水分,再升温回流7h。降温至30-40℃,出料,冷至10℃过滤。滤饼用二甲苯洗涤,洗滤液合并,用盐酸萃取7-8次,分出二甲苯。盐酸萃取液加热回流8h,降温至30℃出料,冷至15-20℃过滤。滤液用液碱调pH14,然后用苯萃取8次,用无水碳酸钠脱水6h以上。过滤,滤液常压蒸去苯,再减压蒸馏,收庥90-110℃(1.33kPa)馏分,得N-氨乙基环庚亚胺(C9H20N2)。将 N-氨乙基环康亚胺、异甲基硫脲硫酸盐加入乙醇中加热回流2.5h,即生成胍乙啶硫酸盐,经精制、干燥,即得成品。
用途简介
该品为抗高血压药。
胍乙啶 物化性质
- 密度:
- 1.13g/cm3
- 沸点:
- 345.6ºC at 760mmHg
- 闪点:
- 162.8ºC
胍乙啶 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MF2975000
- CHEMICAL NAME :
- Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-
- CAS REGISTRY NUMBER :
- 55-65-2
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C10-H22-N4
- MOLECULAR WEIGHT :
- 198.36
- WISWESSER LINE NOTATION :
- T8NTJ A2MYZUM
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1050 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 26,1671,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 845 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3856778
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
4,185,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 224 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3856778
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 15,349,1981
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,112,1973
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,112,1973