乙酸钴

外观与性状：

紫罗兰色结晶粉末

密度：

1.7043g/cm3

熔点：

298ºC (dec.)

沸点：

117.1ºC at 760 mmHg

闪点：

40ºC

存储条件/存储方法：

库房低温,通风,干燥,与食品原料分开存放

稳定性相关：

1.在140℃以上失去结晶水。易溶于水，溶于乙醇，15℃时在100g乙醇中的溶解度为1.49g。溶于醋酸和吡啶，难溶于醋酸酐，不溶于丙酮和苯。有毒，致癌物。应封闭保存。

2.吸入、 摄入对身体有害。吸入可引起咽炎， 继而出现胃肠道刺激症状，如呕吐、腹绞痛、体温上升、 小腿无力等。皮肤接触可引起过敏性皮炎、 接触性皮炎。

其它信息：

1.       性状：紫红色易潮解结晶体。略带醋酸气味，易潮解

2.       密度（g/mL,25/4℃）：1.7043

3.       相对蒸汽密度（g/mL,空气=1）：不确定

4.       熔点（ºC）：290

5.       沸点（ºC,常压）：不确定

6.       沸点（ºC, 5.2 kPa）：不确定

7.       折射率：不确定

8.       闪点（ºC）：不确定

9.       比旋光度（º）：不确定

10.    自燃点或引燃温度（ºC）：不确定

11.    蒸气压（kPa,25 ºC）：不确定

12.    饱和蒸气压（kPa,60 ºC）：不确定

13.    燃烧热（KJ/mol）：不确定

14.    临界温度（ºC）：不确定

15.    临界压力（KPa）：不确定

16.    油水（辛醇/水）分配系数的对数值：不确定

17.    爆炸上限（%,V/V）：不确定

18.    爆炸下限（%,V/V）：不确定

19.    溶解性：溶于水、酸及乙醇,不溶于丙酮和苯，

危险类别码：

R22;R36/37/38;R40;R43;R53

安全说明：

S22-S26-S36/37/39-S45

安全标志：

S22:不要吸入粉尘。
S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
:
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。

危险标志：

Xn:Harmful;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

AG3150000

CHEMICAL NAME :

Acetic acid, cobalt(2+) salt

CAS REGISTRY NUMBER :

71-48-7

LAST UPDATED :

199710

DATA ITEMS CITED :

14

MOLECULAR FORMULA :

C4-H6-O4.Co

MOLECULAR WEIGHT :

177.03

WISWESSER LINE NOTATION :

OV1 2 &-CO-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

503 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

31 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

25 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

15 mg/m3/24H/17W-C

TOXIC EFFECTS :

Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

135 mg/kg/9D-I

TOXIC EFFECTS :

Cardiac - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Neurotransmitters or modulators (putative) - catecholamine levels in sympathetic nerves

MUTATION DATA

TYPE OF TEST :

Morphological transformation

TEST SYSTEM :

Rodent - hamster Embryo

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,193,1979 *** REVIEWS *** IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,363,1991 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,363,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO COBALT METAL, dust and fume-air:10H TWA 0.05 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81777 No. of Facilities: 603 (estimated) No. of Industries: 8 No. of Occupations: 20 No. of Employees: 5023 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81777 No. of Facilities: 622 (estimated) No. of Industries: 13 No. of Occupations: 16 No. of Employees: 15156 (estimated) No. of Female Employees: 4580 (estimated)

毒理学数据：

急性毒性：大鼠口经LD50：503 mg/kg；小鼠静脉LD50：31 mg/kg；兔子静脉LD50：25 mg/kg；

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:4

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积80.3

7.重原子数量:9

8.表面电荷:0

9.复杂度:25.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:3