四氟乙烯

外观与性状：

无色气体

密度：

1.1507

熔点：

-142°C

沸点：

-76.3°C

折射率：

1.241

蒸汽压：

20000mmHg at 25°C

存储条件/存储方法：

库房通风低温干燥,与氧化剂分开存放

稳定性相关：

1.稳定性^[19]   稳定

2.禁配物^[20]   强氧化剂、易燃或可燃物

3.聚合危害^[21]   聚合

其它信息：

1.性状：无色无味气体^[1]

2.熔点（℃）：-142.5^[2]

3.沸点（℃）：-75.9^[3]

4.相对密度（水=1）：1.519（-76℃）^[4]

5.相对蒸气密度（空气=1）：3.87^[5]

6.饱和蒸气压（kPa）：211（15℃）^[6]

7.临界温度（℃）：33.3^[7]

8.临界压力（MPa）：3.82^[8]

9.辛醇/水分配系数：1.21^[9]

10.闪点（℃）：-60^[10]

11.引燃温度（℃）：200^[11]

12.爆炸上限（%）：60^[12]

13.爆炸下限（%）：11^[13]

14.溶解性：不溶于水。^[14]

15.临界密度（g·cm^-3）：0.580

16.临界体积（cm³·mol^-1）：170

17.临界压缩因子：0.270

18.偏心因子：0.226

19.相对密度（20℃，4℃）：1.5201^-76

20.Lennard-Jones参数（A）：5.0473

21.Lennard-Jones参数（K）：164.42

22.van der Waals面积（cm²·mol^-1）：5.820×10⁹

23.van der Waals体积（cm³·mol^-1）：34.020

24.气相标准声称热(焓)( kJ·mol^-1) ：-658.6

25.气相标准熵(J·mol^-1·K^-1) ：300.12

26.气相标准生成自由能( kJ·mol^-1)：-623.7

27.气相标准热熔(J·mol^-1·K^-1)：80.46

风险类别：

2.1

海关代码：

3904610000

危险类别码：

R11

安全说明：

S16-S36/37/39-S45

安全标志：

S16:远离火源。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
:

危险标志：

C,F

CHEMICAL IDENTIFICATION

RTECS NUMBER :

KX4000000

CHEMICAL NAME :

Ethylene, tetrafluoro-

CAS REGISTRY NUMBER :

116-14-3

LAST UPDATED :

199806

DATA ITEMS CITED :

23

MOLECULAR FORMULA :

C2-F4

MOLECULAR WEIGHT :

100.02

WISWESSER LINE NOTATION :

FYFUYFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

40000 ppm/4H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes

REFERENCE :

JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9, 1957-67. For publisher information, see:JJOMDZ Volume(issue)/page/year: 4,262,1962

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

143 gm/m3/4H

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Liver - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 21(5),36,1977

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

116 gm/m3/4H

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Liver - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 21(5),36,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

500 ppm/6H/2W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571191

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

625 ppm/6H/13W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Liver - changes in liver weight Kidney, Ureter, Bladder - proteinuria

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-450,1997

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

5000 ppm/6H/16D-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-450,1997

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2500 ppm/6H/13W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume increased

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-450,1997

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - hamster

DOSE/DURATION :

991 ppm/6H/2W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571191

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - hamster

DOSE/DURATION :

2000 ppm/6H/90D-I

TOXIC EFFECTS :

Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - changes in bladder weight

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555226 ** TUMORIGENIC DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

625 ppm/6H/2Y-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-450,1997

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

312 ppm/6H/2Y-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Liver - angiosarcoma

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-450,1997 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

2489 ppm/6H

SEX/DURATION :

male 2 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571191 *** REVIEWS *** IARC Cancer Review:Animal No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,285,1979 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,285,1979 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83760 No. of Facilities: 622 (estimated) No. of Industries: 24 No. of Occupations: 32 No. of Employees: 5326 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83760 No. of Facilities: 870 (estimated) No. of Industries: 7 No. of Occupations: 9 No. of Employees: 14963 (estimated) No. of Female Employees: 325 (estimated)

毒理学数据：

1.急性毒性^[15]  LC50：16400mg/m³（大鼠吸入，4h）；143g/m³（小鼠吸入，4h）；116g/m³（豚鼠吸入，4h）

2.刺激性  暂无资料

3.致癌性^[16]  IARC致癌性评论：组2B，对人类是可能致癌物。

生态数据：

1.生态毒性  暂无资料

2.生物降解性  暂无资料

3.非生物降解性^[17]  空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期为75d（理论）。

4.其他有害作用^[18]  该物质对环境可能有危害，应特别注意对大气的污染。

分子结构数据

1、  摩尔折射率：11.71

2、  摩尔体积（cm³/mol）：76.5

3、  等张比容（90.2K）：129.3

4、  表面张力（dyne/cm）：8.1

5、  极化率（10-24cm3）：4.64

计算化学数据

1.疏水参数计算参考值（XlogP）:1.3

2.氢键供体数量:0

3.氢键受体数量:4

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:6

8.表面电荷:0

9.复杂度:55.6

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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  四氟乙烯质谱(MS)