硝酸丙酯

密度：

1.05

熔点：

-100ºC

沸点：

110.5ºC

折射率：

1.402

存储条件/存储方法：

库房通风低温干燥,与氧化剂分开存放

稳定性相关：

1.稳定性^[16]  稳定

2.禁配物^[17]  强还原剂、强酸、磷、铝、硫

3.避免接触的条件^[18]  受热

4.聚合危害^[19]  不聚合

5.分解产物^[20]  氮氧化物

其它信息：

1.性状：白色至淡黄色液体，有类似醚的气味。^[1]

2.熔点（℃）：-100^[2]

3.沸点（℃）：110.5^[3]

4.相对密度（水=1）：1.05^[4]

5.相对蒸气密度（空气=1）：3.62^[5]

6.饱和蒸气压（kPa）：2.43（20℃）^[6]

7.辛醇/水分配系数：1.74（计算）^[7]

8.闪点（℃）：20^[8]

9.引燃温度（℃）：175^[9]

10.爆炸上限（%）：100.0^[10]

11.爆炸下限（%）：2.0^[11]

12.溶解性：不溶于水，溶于乙醇、乙醚。^[12]

包装等级：

II

风险类别：

3.1

CHEMICAL IDENTIFICATION

RTECS NUMBER :

UK0350000

CHEMICAL NAME :

n-Propyl nitrate

CAS REGISTRY NUMBER :

627-13-4

BEILSTEIN REFERENCE NO. :

1701406

LAST UPDATED :

199712

DATA ITEMS CITED :

27

MOLECULAR FORMULA :

C3-H7-N-O3

MOLECULAR WEIGHT :

105.11

WISWESSER LINE NOTATION :

WNO3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5816 ppm/4H

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,80,1958

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

5816 ppm/4H

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,80,1958

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 118,77,1956

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

100 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 118,77,1956

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

200 mg/kg

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 118,77,1956 *** REVIEWS *** ACGIH TLV-STEL 172 mg/m3 (40 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 107 mg/m3 (25 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 25 ppm (110 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,217,1971 OSHA PEL (Gen Indu):8H TWA 25 ppm (110 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 25 ppm (110 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 25 ppm (110 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 25 ppm (110 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 25 ppm (110 mg/m3);STEL 40 ppm (170 mg/m3) JAN 1993 OEL-BELGIUM:TWA 25 ppm (107 mg/m3);STEL 40 ppm (172 mg/m3) JAN 1993 OEL-DENMARK:TWA 25 ppm (110 mg/m3) JAN 1993 OEL-FINLAND:TWA 25 ppm (105 mg/m3);STEL 40 ppm (175 mg/m3) JAN 1993 OEL-FRANCE:TWA 25 ppm (105 mg/m3) JAN 1993 OEL-GERMANY:TWA 25 ppm (110 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 25 ppm (110 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 25 ppm (110 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 25 ppm (110 mg/m3) JAN 1993 OEL-TURKEY:TWA 25 ppm (110 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO n-PROPYL NITRATE-air:10H TWA 25 ppm;STEL 40 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7139 No. of Facilities: 30 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1844 (estimated) No. of Female Employees: 272 (estimated)

毒理学数据：

1.急性毒性^[13]

LD50：200mg/kg（兔静脉）

LC50：38610mg/m³（大鼠吸入，4h）

2.刺激性  暂无资料

3.亚急性与慢性毒性^[14]  大鼠吸入2110ppm，26周，9/20死亡。

生态数据：

1.生态毒性  暂无资料

2.生物降解性  暂无资料

3.非生物降解性^[15]  空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期为22d（理论）。

计算化学数据

1.疏水参数计算参考值（XlogP）:1.4

2.氢键供体数量:0

3.氢键受体数量:3

4.可旋转化学键数量:2

5.互变异构体数量:无

6.拓扑分子极性表面积55

7.重原子数量:7

8.表面电荷:0

9.复杂度:57.7

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1