L-瓜氨酸

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学
  • 上游产品
  • 下游产品
  • 表征图谱

L-瓜氨酸 基本信息

中文名称:
L-瓜氨酸 
中文别名:
L-瓜氨酸;
L-(+)-瓜氨酸;
L-(+)-2-氨基-5-脲戊酸;
L(+)-2-氨基-5-脲戊酸;
脲氨基戊酸 
英文名称:
L-citrulline
英文别名:
L-citrulline;
d-ureidonorvaline;
(2S)-2-amino-5-(carbamoylamino)pentanoic acid;
citrulline;
(S)-2-Amino-5-ureidopentanoic acid;
[14C]-Citrulline;
L-Cytrulline;
L-(+)-Citrulline;
(S)-2-amino-5-(carbamoyl amino)pentanoic acid;
L-Citrulline;
N5-Carbamoyl-L-ornithine;
Sitrulline;
L(+)-Citrulline;
(S)-2-Amino-5-ureidopentanoic acid L-2-Amino-5-ureidovaleric acid;
L-2-Amino-5-ureidovaleric acid;
N5-(Aminocarbonyl)ornithine 
CAS No.:
372-75-8
分 子 式:
C6H13N3O3
分 子 量:
175.19
精确分子量:
175.09600
PSA:
118.44000
MDL:
MFCD00064397
EINECS:
206-759-6
BRN:
1725416
InChI:
InChI=1/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1
风险术语:
R36/37/38;
安全术语:
S24/25;S36;S26;
分子结构式:
SDS:
查看

L-瓜氨酸 制备方法及用途

制备方法

1. 首次从西瓜汁中分离出的一种氨基酸。由精氨酸的碱水解得到。

合成制备方法

1. 首次从西瓜汁中分离出的一种氨基酸。由精氨酸的碱水解得到。

用途简介

提高免疫系统功能,维护关节运动的机能,平衡正常的血糖水平。含丰富的抗氧化剂吸收有害的自由基,帮助保持胆固醇的正常水平。提高建康的性生活功能:瓜氨酸可在人体内与氨作用,生成精氨酸和一氧化氮。一氧化氮会活化guanylylcyclase酵素,导致平滑肌舒张。它也可以使人的血管获得松弛,用于增强男性性功能,以及治疗性功能障碍。

用途

氨基酸类药物。可同鸟氨酸、精氨酸等合用于治疗高氨血症

L-瓜氨酸 物化性质

外观与性状:
白色至灰白色结晶粉末
密度:
1.289 g/cm3
熔点:
214 °C
沸点:
386.7ºC at 760 mmHg
闪点:
187.7ºC
水溶解性:
200 g/L (20 ºC)
折射率:
26 ° (C=8, 6mol/L HCl)
存储条件/存储方法:

储存于阴凉干燥处密封保存。

稳定性相关:

1. 瓜氨酸与鸟氨酸相同,仅存在于肝脏中,不是蛋白质的构成成分,为人体脲循环的一个重要中间物。

2. 存在于烟叶中。

其它信息:

1. 性状:白色结晶。味苦。

2. 溶解性:能溶于水,不溶于甲醇和乙醇

3. 熔点(ºC)222

4. 相对密度(d204)   :1.289

L-瓜氨酸 安全信息

海关代码:
29241900
WGK_Germany:
3
德国有关水污染物质的分类清单
危险类别码:
R36/37/38
安全说明:
S24/25
安全标志:
S26:万一接触眼睛,立即使用大量清水冲洗并送医诊治。
S36:穿戴合适的防护服装。
S24/25:防止皮肤和眼睛接触。
危险标志:
Xi

L-瓜氨酸 毒理性

毒理学数据:

二、毒理学数据:

急性毒性:不可用 。

生态数据:

三、生态学数据:

1、其它有害作用:该物质对环境可能有危害,对水体应给予特别注意。

L-瓜氨酸 MSDS

Name: L-Citrulline Material Safety Data Sheet
Synonym: None
CAS: 372-75-8
Section 1 - Chemical Product   MSDS Name:L-Citrulline Material Safety Data Sheet
Synonym:None

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
372-75-8 L-Citrulline 100 % 206-759-6
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
  Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Keep container closed when not in use.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 372-75-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Solid
Color: white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 220 deg C (decomposes)
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Soluble in water.
Specific Gravity/Density: Not available.
Molecular Formula: C6H13N3O3
Molecular Weight: 175.1093

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidants.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 372-75-8 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
L-Citrulline - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.

Section 14 - TRANSPORT INFORMATION
 
IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 372-75-8: 0
Canada
CAS# 372-75-8 is listed on Canada's NDSL List.
CAS# 372-75-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 372-75-8 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

L-瓜氨酸 分子结构与计算化学数据

分子结构数据

1、   摩尔折射率:42.06

2、   摩尔体积(cm3/mol):135.8

3、   等张比容(90.2K):381.1

4、   表面张力(dyne/cm):61.9

5、   极化率(10-24cm3):16.67

计算化学数据

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:4

3.氢键受体数量:4

4.可旋转化学键数量:5

5.互变异构体数量:3

6.拓扑分子极性表面积118

7.重原子数量:12

8.表面电荷:0

9.复杂度:171

10.同位素原子数量:0

11.确定原子立构中心数量:1

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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