乙二醇二甲醚

外观与性状：

水白色液体

密度：

0.867 g/mL at 25 °C(lit.)

熔点：

-69 °C

沸点：

85 °C(lit.)

闪点：

32 °F

水溶解性：

Miscible

折射率：

n20/D 1.379(lit.)

蒸汽压：

187mmHg at 25°C

蒸汽密度：

3.1 (20 °C, vs air)

存储条件/存储方法：

库房通风低温干燥,与氧化剂分开存放

稳定性相关：

1.化学性质：性质稳定，不易发生反应。但能与碘化氢、溴化氢、浓硫酸反应。酸性催化剂存在时，高温能发生分解。在150℃以下对碱金属稳定，金属钠可用乙二醇二烷基醚干燥。但能与钠钾合金或钾反应。苯基锂、丁基锂使乙二醇二甲醚稍有分解。与活性小的Grignard试剂如甲基氯化镁在通常条件下不发生反应，但加热到150~200℃时与活性大的试剂如甲基碘化镁作用而分解。对碱金属的氢化物稳定，可作氢化铝锂的稳定剂、精制剂。在氧的作用下生成过氧化物，光和热对过氧化物的生成有促进作用。生成的过氧化物不稳定，分解成醛、酮、酸及其他杂质。

2.稳定性^[17]  稳定

3.禁配物^[18]  强氧化剂、强酸

4.避免接触的条件^[19]  空气、光照

5.聚合危害^[20]  不聚合

其它信息：

1.性状：无色液体，略有醚味。^[1]

2.熔点（℃）：-58^[2]

3.沸点（℃）：82~83^[3]

4.相对密度（水=1）：0.87（20℃）^[4]

5.相对蒸气密度（空气=1）：3.11^[5]

6.饱和蒸气压（kPa）：6.40（20℃）^[6]

7.燃烧热（kJ/mol）：-2521.2^[7]

8.临界温度（℃）：263^[8]

9.临界压力（MPa）：3.87^[9]

10.辛醇/水分配系数：-0.21^[10]

11.闪点（℃）：-2（CC）^[11]

12.引燃温度（℃）：202^[12]

13.爆炸上限（%）：18.7^[13]

14.爆炸下限（%）：1.9^[14]

15.溶解性：溶于水，溶于乙醇、烃类。^[15]

16.折射率（n20ºC）：1.3796

17.黏度（mPa·s,20ºC）：1.1

18.蒸发热（KJ/mol）：28.14

19.熔化热（KJ/kg）：139.4

20.生成热（KJ/mol）：491.95

21.燃烧热（KJ/mol）：2520.82

22.比热容（KJ/(kg·K),定压）：1.83

23.电导率（S/m,25ºC）：0.47×10^-7

24.蒸气压（kPa,20ºC）：6.40

25.相对密度（20℃，4℃）：0.8665

26.相对密度（25℃，4℃）：0.8556³⁰

27.临界密度（g·cm^-3）：0.293

28.临界体积（cm³·mol^-1）：308

29.临界压缩因子：0.269

30.偏心因子：0.346

31.溶度参数(J·cm^-3)^0.5：17.732

32.van der Waals面积（cm²·mol^-1）：8.140×10⁹

33.van der Waals体积（cm³·mol^-1）：55.200

34.气相标准燃烧热(焓)(kJ·mol^-1)：-2662.95

35.气相标准声称热(焓)( kJ·mol^-1) ：-340.24

36.液相标准燃烧热(焓)(kJ·mol^-1)：-2626.65

37.液相标准声称热(焓)( kJ·mol^-1)：-376.64

38.液相标准热熔(J·mol^-1·K^-1)：186.5

包装等级：

II

风险类别：

3

海关代码：

29091900

WGK_Germany：

1
德国有关水污染物质的分类清单

危险类别码：

R11;R19;R20;R60;R61

安全说明：

S53-S45

RTECS号：

KI1451000

安全标志：

S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S53:避免暴露——使用前先阅读专门的说明。

危险标志：

F:Flammable

CHEMICAL IDENTIFICATION

RTECS NUMBER :

KI1451000

CHEMICAL NAME :

Ethane, 1,2-dimethoxy-

CAS REGISTRY NUMBER :

110-71-4

BEILSTEIN REFERENCE NO. :

1209237

LAST UPDATED :

199806

DATA ITEMS CITED :

20

MOLECULAR FORMULA :

C4-H10-O2

MOLECULAR WEIGHT :

90.14

WISWESSER LINE NOTATION :

1O2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0539769

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

63 gm/m3/6H

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - irritability

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571323

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571323

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

3200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571323

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

400 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571323

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0539769 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4000 ppm/4H/2W-I

TOXIC EFFECTS :

Behavioral - changes in psychophysiological tests Lungs, Thorax, or Respiration - other changes Related to Chronic Data - death

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 25,369,1964 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

660 mg/kg

SEX/DURATION :

female 8-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - homeostasis

REFERENCE :

REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,157,1991

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

660 mg/kg

SEX/DURATION :

female 8-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :

REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,157,1991

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

660 mg/kg

SEX/DURATION :

female 8-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :

REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,157,1991

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1960 mg/kg

SEX/DURATION :

female 7-10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :

NISFAY Nippon Sanka Fujinka Gakkai Zasshi. Journal of the Japan Society of Obstetrics and Gynecology. (Nippon Sanka Fujinka Gakkai Zasshi, Hoken Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan) V.1- 1949- Volume(issue)/page/year: 32,113,1980

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1400 mg/kg

SEX/DURATION :

female 7-10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous System

REFERENCE :

NISFAY Nippon Sanka Fujinka Gakkai Zasshi. Journal of the Japan Society of Obstetrics and Gynecology. (Nippon Sanka Fujinka Gakkai Zasshi, Hoken Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan) V.1- 1949- Volume(issue)/page/year: 32,113,1980

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

361 mg/kg

SEX/DURATION :

female 11 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,321,1987

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

16 gm/kg

SEX/DURATION :

female 7-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 57,141,1984 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83728 No. of Facilities: 68 (estimated) No. of Industries: 3 No. of Occupations: 2 No. of Employees: 265 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83728 No. of Facilities: 94 (estimated) No. of Industries: 4 No. of Occupations: 7 No. of Employees: 3319 (estimated) No. of Female Employees: 1003 (estimated)

毒理学数据：

1、急性毒性：小鼠经口LC50：3200mg/kg；大鼠经口LD50：>5000mg/kg；兔子经口LD50：320mg/kg；大鼠经口LDL0：1000mg/kg；大鼠皮肤LD50：5370mg/kg；兔子皮肤LDL0：2000mg/kg；大鼠吸入LDL0：63mg/m3/6H

2、吸入和经口属低毒类。吸入高浓度蒸气时，对肺、肝、肾等器官都有损害。

3.急性毒性^[16]  LD50：775mg/kg（大鼠经口）

生态数据：

该物质对水体有轻微的危害，不要让该产品接触地下水、水道或者污水系统。

分子结构数据

1、摩尔折射率：24.07

2、摩尔体积（cm³/mol）：1107.2

3、等张比容（90.2K）：230.6

4、表面张力（dyne/cm）：21.3

5、极化率（10^-24cm³）：9.54

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:2

4.可旋转化学键数量:3

5.互变异构体数量:无

6.拓扑分子极性表面积18.5

7.重原子数量:6

8.表面电荷:0

9.复杂度:17.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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  2-二甲氧基乙烷核磁图(¹HNMR)
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  2-二甲氧基乙烷Raman光谱
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