乙二醇二甲醚

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学
  • 上游产品
  • 下游产品
  • 表征图谱

乙二醇二甲醚 基本信息

中文名称:
乙二醇二甲醚 
中文别名:
乙二醇二甲醚;
1,2-二甲氧基乙烷 
英文名称:
alpha,beta-Dimethoxyethane
英文别名:
1,2-dimethoxyethane;
Ethylene glycol dimethyl ether;
Ethylene glycol dimethyl ether,stabilized with BHT;
ethylene glycol dimethyl ether;
1,2-Dimethoxydiphenid;
dimethyl cellosolve;
Dimethylglycol,Ethylene glycol dimethyl ether,Monoglyme;
Ethylene glycol dimethyl ether,AcroSeal,Extra Dry;
1,2-Dimethoxyethane;
1,2-dimethoxy-ethane;
1,2-dimethyloxyethane;
1,2-methoxyethane 
CAS No.:
110-71-4
分 子 式:

C4H10O2

分 子 量:
90.12
精确分子量:
90.06810
PSA:
18.46000
LogP:
LogP值指的是某物质在正辛醇/水两相体系中的分配系数的对数值,反映了物质在油水两相中的分配情况。其中、LogP值越大,说明该物质越亲油;反之,LogP值越小,则说明该物质越亲水。
MDL:
MFCD00008502
EINECS:
203-794-9
BRN:
1209237
InChI:
InChI=1/C4H10O2/c1-4(5-2)6-3/h4H,1-3H3
危险品标志:

FlammableF;ToxicT

风险术语:

R11;R19;R20

安全术语:

S16;S33;S45

分子结构式:
SDS:
查看

乙二醇二甲醚 制备方法及用途

制备方法

1.由乙二醇单甲醚与金属钠;氯甲烷反应而得。将乙二醇单甲醚与金属钠一起回流,直至金属钠完全反应,降温至45℃,通入氯甲烷。反应毕,进行分馏,收集84-85.5℃馏分,即得成品。精制方法:过氧化物的检验方法与乙醚相同。过氧化物可用氯化亚锡一起回流或通过活性氧化铝除去。然后添加少量的金属钠以除微量的水分。其他精制方法有先用钠丝干燥,在氮气流下加氢化铝锂蒸馏。也可以先用无水氯化钙干燥数天,过滤、加金属钠蒸馏,或加氢化铝锂保存,用前蒸馏。2.边搅拌边将金属钠于60℃下分次少量加到乙二醇单甲醚中,控制温度在78~81℃,金属钠加完后,降温至45℃,然后通入氯甲烷。反应式为: 反应结束后,蒸馏,收集84.5~85.5℃馏分,即得乙二醇二甲醚。3.用钠丝干燥后,在氮气存在下加氢化铝锂蒸馏,也可用无水氯化钙干燥数天后,滤去氯化钙,再加金属钠蒸馏,或加入氢化铝锂后放置,现用现蒸馏。

合成制备方法

1.由乙二醇单甲醚与金属钠;氯甲烷反应而得。将乙二醇单甲醚与金属钠一起回流,直至金属钠完全反应,降温至45℃,通入氯甲烷。反应毕,进行分馏,收集84-85.5℃馏分,即得成品。

精制方法:过氧化物的检验方法与乙醚相同。过氧化物可用氯化亚锡一起回流或通过活性氧化铝除去。然后添加少量的金属钠以除微量的水分。其他精制方法有先用钠丝干燥,在氮气流下加氢化铝锂蒸馏。也可以先用无水氯化钙干燥数天,过滤、加金属钠蒸馏,或加氢化铝锂保存,用前蒸馏。

2.边搅拌边将金属钠于60℃下分次少量加到乙二醇单甲醚中,控制温度在78~81℃,金属钠加完后,降温至45℃,然后通入氯甲烷。反应式为:

反应结束后,蒸馏,收集84.5~85.5℃馏分,即得乙二醇二甲醚。

3.用钠丝干燥后,在氮气存在下加氢化铝锂蒸馏,也可用无水氯化钙干燥数天后,滤去氯化钙,再加金属钠蒸馏,或加入氢化铝锂后放置,现用现蒸馏。

用途简介

主要主要用于聚合物化学、电化学、硼化学工艺领域,还用于树脂,硝化纤维素等有机合成溶剂。

用途

1.用作硝酸纤维素、树脂等的溶剂以及制备碱金属氧化物、硼烷时的溶剂。萘、联苯、三联苯、蒽等芳香烃在乙二醇二甲醚中与钠生成络合物。钠-萘络合物在聚四氟乙烯等含氟树脂黏合时用于表面处理。钠-联苯络合物用于汽油中的卤素测定。还可用于从稀乙酸水溶液中回收乙酸。也用于脱漆剂、稀释剂及增加润滑油的黏度等。

2.用作溶剂、医药抽提剂、有机合成中间体、催化剂、腐蚀抑制剂。[22]

乙二醇二甲醚 物化性质

外观与性状:
水白色液体
密度:
0.867 g/mL at 25 °C(lit.)
熔点:
-69 °C
沸点:
85 °C(lit.)
闪点:
32 °F
水溶解性:
Miscible
折射率:
n20/D 1.379(lit.)
蒸汽压:
187mmHg at 25°C
蒸汽密度:
3.1 (20 °C, vs air)
存储条件/存储方法:
库房通风低温干燥,与氧化剂分开存放
稳定性相关:

1.化学性质:性质稳定,不易发生反应。但能与碘化氢、溴化氢、浓硫酸反应。酸性催化剂存在时,高温能发生分解。在150℃以下对碱金属稳定,金属钠可用乙二醇二烷基醚干燥。但能与钠钾合金或钾反应。苯基锂、丁基锂使乙二醇二甲醚稍有分解。与活性小的Grignard试剂如甲基氯化镁在通常条件下不发生反应,但加热到150~200℃时与活性大的试剂如甲基碘化镁作用而分解。对碱金属的氢化物稳定,可作氢化铝锂的稳定剂、精制剂。在氧的作用下生成过氧化物,光和热对过氧化物的生成有促进作用。生成的过氧化物不稳定,分解成醛、酮、酸及其他杂质。

2.稳定性[17]  稳定

3.禁配物[18]  强氧化剂、强酸

4.避免接触的条件[19]  空气、光照

5.聚合危害[20]  不聚合

其它信息:

1.性状:无色液体,略有醚味。[1]

2.熔点(℃):-58[2]

3.沸点(℃):82~83[3]

4.相对密度(水=1):0.87(2ȍ2*5E}`Eȍ2*5Ep>5.相对蒸气密度(空气=1):3.11[5]

6.饱和蒸气压(kPa):6.40(20℃)[6]

7.燃烧热(kJ/mol):-2521.2[7]

8.临界温度(℃):263[8]

9.临界压力(MPa):3.87[9]

10.辛醇/水分配系数:-0.21[10]

11.闪点(℃):-2(CC)[11]

12.引燃温度(℃):202[12]

13.爆炸上限(%):18.7[13]

14.爆炸下限(%):1.9[14]

15.溶解性:溶于水,溶于乙醇、烃类。[15]

16.折射率(n20ºC):1.3796

17.黏度(mPa·s,20ºC):1.1

18.蒸发热(KJ/mol):28.14

19.熔化热(KJ/kg):139.4

20.生成热(KJ/mol):491.95

21.燃烧热(KJ/mol):2520.82

22.比热容(KJ/(kg·K),定压):1.83

23.电导率(S/m,25ºC):0.47×10-7

24.蒸气压(kPa,20ºC):6.40

25.相对密度(20℃,4℃):0.8665

26.相对密度(25℃,4℃):0.855630

27.临界密度(g·cm-3):0.293

28.临界体积(cm3·mol-1):308

29.临界压缩因子:0.269

30.偏心因子:0.346

31.溶度参数(J·cm-3)0.5:17.732

32.van der Waals面积(cm2·mol-1):8.140×109

33.van der Waals体积(cm3·mol-1):55.200

34.气相标准燃烧热(焓)(kJ·mol-1):-2662.95

35.气相标准声称热(焓)( kJ·mol-1) :-340.24

36.液相标准燃烧热(焓)(kJ·mol-1):-2626.65

37.液相标准声称热(焓)( kJ·mol-1):-376.64

38.液相标准热熔(J·mol-1·K-1):186.5

乙二醇二甲醚 安全信息

包装等级:
II
风险类别:
3
海关代码:
29091900
WGK_Germany:
1
德国有关水污染物质的分类清单
危险类别码:
R11;R19;R20;R60;R61
安全说明:
S53-S45
RTECS号:
KI1451000
安全标志:
S45:出现意外或者感到不适,立刻到医生那里寻求帮助(最好带去产品容器标签)。
S53:避免暴露——使用前先阅读专门的说明。
危险标志:
F:Flammable

乙二醇二甲醚 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KI1451000
CHEMICAL NAME :
Ethane, 1,2-dimethoxy-
CAS REGISTRY NUMBER :
110-71-4
BEILSTEIN REFERENCE NO. :
1209237
LAST UPDATED :
199806
DATA ITEMS CITED :
20
MOLECULAR FORMULA :
C4-H10-O2
MOLECULAR WEIGHT :
90.14
WISWESSER LINE NOTATION :
1O2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0539769
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
63 gm/m3/6H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - irritability
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571323
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571323
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571323
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571323
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0539769 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4000 ppm/4H/2W-I
TOXIC EFFECTS :
Behavioral - changes in psychophysiological tests Lungs, Thorax, or Respiration - other changes Related to Chronic Data - death
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 25,369,1964 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
660 mg/kg
SEX/DURATION :
female 8-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,157,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
660 mg/kg
SEX/DURATION :
female 8-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,157,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
660 mg/kg
SEX/DURATION :
female 8-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,157,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1960 mg/kg
SEX/DURATION :
female 7-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
REFERENCE :
NISFAY Nippon Sanka Fujinka Gakkai Zasshi. Journal of the Japan Society of Obstetrics and Gynecology. (Nippon Sanka Fujinka Gakkai Zasshi, Hoken Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan) V.1- 1949- Volume(issue)/page/year: 32,113,1980
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1400 mg/kg
SEX/DURATION :
female 7-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
NISFAY Nippon Sanka Fujinka Gakkai Zasshi. Journal of the Japan Society of Obstetrics and Gynecology. (Nippon Sanka Fujinka Gakkai Zasshi, Hoken Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan) V.1- 1949- Volume(issue)/page/year: 32,113,1980
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
361 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,321,1987
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
16 gm/kg
SEX/DURATION :
female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 57,141,1984 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83728 No. of Facilities: 68 (estimated) No. of Industries: 3 No. of Occupations: 2 No. of Employees: 265 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83728 No. of Facilities: 94 (estimated) No. of Industries: 4 No. of Occupations: 7 No. of Employees: 3319 (estimated) No. of Female Employees: 1003 (estimated)
毒理学数据:

1、急性毒性:小鼠经口LC50:3200mg/kg;大鼠经口LD50:>5000mg/kg;兔子经口LD50:320mg/kg;大鼠经口LDL0:1000mg/kg;大鼠皮肤LD50:5370mg/kg;兔子皮肤LDL0:2000mg/kg;大鼠吸入LDL0:63mg/m3/6H

2、吸入和经口属低毒类。吸入高浓度蒸气时,对肺、肝、肾等器官都有损害。

3.急性毒性[16]  LD50:775mg/kg(大鼠经口)

生态数据:

该物质对水体有轻微的危害,不要让该产品接触地下水、水道或者污水系统。

乙二醇二甲醚 MSDS

第一部分:化学品名称

乙二醇二甲醚 分子结构与计算化学数据

分子结构数据

1、摩尔折射率:24.07

2、摩尔体积(cm3/mol):1107.2

3、等张比容(90.2K):230.6

4、表面张力(dyne/cm):21.3

5、极化率(10-24cm3):9.54

计算化学数据

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:0

3.氢键受体数量:2

4.可旋转化学键数量:3

5.互变异构体数量:无

6.拓扑分子极性表面积18.5

7.重原子数量:6

8.表面电荷:0

9.复杂度:17.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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