环丁砜

外观与性状：

透明无色液体

密度：

1.261 g/mL at 25 °C(lit.)

熔点：

27.4 °C

沸点：

285 °C

闪点：

330 °F

水溶解性：

soluble

折射率：

n20/D 1.484(lit.)

蒸汽压：

0.00479mmHg at 25°C

蒸汽密度：

4.2 (vs air)

存储条件/存储方法：

采用镀锌铁桶包装，常温或低温下贮存。按一般化学品规定贮运。

稳定性相关：

化学性质：热稳定性好，加热至220℃以上5小时，仅有2%发生分解生成二氧化硫。对酸和碱稳定，加热到沸点附近不发生分解。可与氯发生反应。能与钴和硼的化合物形成络合物。

本品毒性较低，一般动物经口ＬＤ５００．７３～９．４ｇ／ｋｇ。当溅及皮肤时可用水冲洗。
　

其它信息：

1.       性状：无色透明液体。

2.       沸点（ºC,101.3kPa）：287.3

3.       熔点（ºC）：28.45

4.       相对密度（g/mL,30/4ºC）：1.2614

5.       相对蒸汽密度（g/mL,空气=1）：4.2

6.       折射率（30ºC）：1.4820

7.       黏度（mPa·s,30ºC）：10.286

8.       闪点（ºC）：166

9.       蒸发热（KJ/mol,100ºC）：62.8

10.    熔化热（KJ/mol）：1.42

11.    燃烧热（KJ/kg）：11.42

12.    比热容（KJ/(kg·K),30ºC,定压）：1.50

13.    电导率（S/m,30ºC）：<2×10^-8

14.    蒸气压（kPa,150ºC）：1.93

15.    蒸气压（kPa,118ºC）：0.67

16.    溶解性：几乎能与所有有机溶剂混溶。除脂肪烃外，能溶解大多数有机化合物。也能溶解无机盐类和高分子化合物。

海关代码：

29349990

WGK_Germany：

1
德国有关水污染物质的分类清单

危险类别码：

R22

安全说明：

S23-S25

RTECS号：

XN0700000

安全标志：

S23:不要吸入蒸汽。
S25:避免接触眼睛。

危险标志：

Xn:Harmful

CHEMICAL IDENTIFICATION

RTECS NUMBER :

XN0700000

CHEMICAL NAME :

Thiophene, tetrahydro-, 1,1-dioxide

CAS REGISTRY NUMBER :

126-33-0

BEILSTEIN REFERENCE NO. :

0107765

LAST UPDATED :

199712

DATA ITEMS CITED :

19

MOLECULAR FORMULA :

C4-H8-O2-S

MOLECULAR WEIGHT :

120.18

WISWESSER LINE NOTATION :

T5SWTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 23,302,1966 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1540 uL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :

LC - Lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>250 mg/m3/8H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0535072

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>3800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 23,302,1966

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1600 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 4,22,1984

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1620 uL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0535072

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1900 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,560,1969

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1250 mg/kg

TOXIC EFFECTS :

Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :

RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 42,97,1979

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1080 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 119,423,1959

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

3180 uL/kg

TOXIC EFFECTS :

Liver - other changes Kidney, Ureter, Bladder - other changes Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0535072 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

6750 mg/kg/2W-I

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533719

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

6350 mg/kg/23W-I

TOXIC EFFECTS :

Vascular - pulse pressure increase

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533719

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

495 mg/m3/8H/27D-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes Liver - fatty liver degeneration Related to Chronic Data - death

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 40,463,1977

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

200 mg/m3/23H/90D-C

TOXIC EFFECTS :

Blood - changes in leukocyte (WBC) count

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 40,463,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80612 No. of Facilities: 27 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 143 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80612 No. of Facilities: 386 (estimated) No. of Industries: 5 No. of Occupations: 10 No. of Employees: 6635 (estimated) No. of Female Employees: 322 (estimated)

毒理学数据：

1、皮肤/眼睛刺激数据 ：兔子眼睛接触：253mg轻度反应

2、急性毒性数据：大鼠经口LD50：1540 uL/kg；大鼠吸入LC：>250 mg/m3/8H；

                                  大鼠皮肤LD50：>3800 mg/kg；大鼠腹腔LD50：1600 mg/kg；

                                  大鼠皮下LD50：1620 uL/kg；小鼠经口LD50：1900 mg/kg；

                                  小鼠腹腔LD50：1250 mg/kg；小鼠静脉LD50：1080 mg/kg；

                                   兔子皮肤LD50：3180 uL/kg

3、其它多剂量数据：大鼠经口TDLo：6750 mg/kg/2W-I；狗经口TDLo：6350 mg/kg/23W-I

                                      灵长类动物-猴子吸入TCLo：495 mg/m3/8H/27D-I

                                      啮齿动物-豚鼠吸入TCLo：200 mg/m3/23H/90D-C

生态数据：

 

总括注解 

水危害级别1（德国规例）（通过名单进行自我评估）该物质对水有稍微危害的。

 不要让未稀释或大量的产品接触地下水、水道或污水系统。 

若无政府许可，勿将材料排入周围环境。

分子结构数据

1、   摩尔折射率：27.33

2、   摩尔体积（cm³/mol）：95.2

3、   等张比容（90.2K）：232.7

4、   表面张力（dyne/cm）：35.6

5、   极化率（10^-24cm³）：10.83

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:2

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积42.5

7.重原子数量:7

8.表面电荷:0

9.复杂度:128

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  环丁砜红外图谱(IR1)
• 
  环丁砜红外图谱(IR2)
• 
  环丁砜质谱(MS)
• 
  环丁砜核磁图(¹³CNMR)