N-甲基乙酰胺

外观与性状：

无色液体或固体

密度：

0.957 g/mL at 25 °C(lit.)

熔点：

26-28 °C(lit.)

沸点：

204-206 °C(lit.)

闪点：

227 °F

水溶解性：

soluble

折射率：

n20/D 1.433(lit.)

存储条件/存储方法：

库房通风低温干燥

稳定性相关：

1. 化学性质：与氯化氢作用能生成两种形式的盐，即CH3CONHCH3·HCl(熔点67.2～69.4℃)和(CH3CONHCH3)2·HCl。与金属钠在室温下几乎不发生反应。与亚硝酸反应生成亚硝基化合物。与乙酸酐回流煮沸生成N-甲基二乙酰胺。受酸或碱的作用，N-甲基乙酰胺都能发生水解。

2. 存在于烟气中。

其它信息：

1.       性状：白色针状结晶

2.       密度（g/mL,25/4℃）：0.9371

3.       熔点（ºC）：26~28

4.       沸点（ºC,常压）：204~206

5.       沸点（ºC,12kPa）：140.5

6.       折射率（28ºC）：1.4301

7.       黏度（mPa·s,35ºC）：3.23

8.       闪点（ºC）：108

9.       蒸发热（KJ/mol,115~205ºC）：59.5

10.    熔化热（J/mol）：8.37

11.    临界温度（ºC）：417

12.    电导率（S/m,40ºC）：2×10^-1

13.    蒸气压（kPa,56ºC）：0.2

14.    溶解性：易溶于水、醇、醚、丙酮、苯、氯仿，不溶于溶剂汽油。

海关代码：

2942000000

WGK_Germany：

2
德国有关水污染物质的分类清单

危险类别码：

R61

安全说明：

S53-S45

RTECS号：

AC5960000

安全标志：

S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S53:避免暴露——使用前先阅读专门的说明。
S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
:

危险标志：

T:Toxic;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

AC5960000

CHEMICAL NAME :

Acetamide, N-methyl-

CAS REGISTRY NUMBER :

79-16-3

LAST UPDATED :

199710

DATA ITEMS CITED :

23

MOLECULAR FORMULA :

C3-H7-N-O

MOLECULAR WEIGHT :

73.11

WISWESSER LINE NOTATION :

1VM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2750 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3600 mg/kg

TOXIC EFFECTS :

Gastrointestinal - other changes Liver - other changes Endocrine - other changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

4380 mg/kg

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

4015 mg/kg

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

16940 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Bird - chicken

DOSE/DURATION :

14 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

90 gm/kg/90D-C

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2 gm/kg

SEX/DURATION :

female 7 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

DOSE :

1200 mg/kg

SEX/DURATION :

female 10-11 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

2 gm/kg

SEX/DURATION :

female 15-16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

3250 mg/kg

SEX/DURATION :

female 6-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

3250 mg/kg

SEX/DURATION :

female 6-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

130 mg/kg

SEX/DURATION :

female 6-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :

DNA inhibition

MUTATION DATA

TYPE OF TEST :

Sister chromatid exchange

TEST SYSTEM :

Rodent - hamster Ovary

DOSE/DURATION :

10 gm/L

REFERENCE :

APHGAO Acta Pharmaceutica Hungarica. (Kultura, POB 149, H-1389 Budapest, Hungary) 1953- Adopts V.24 in 1955. Volume(issue)/page/year: 56,97,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4317 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 851 (estimated) No. of Female Employees: 187 (estimated)

毒理学数据：

大鼠经口LD50为3200mg/kg。小鼠静脉注射LD50为4010mg/kg。小鼠腹腔注射LD50为4380mg/kg。妊娠13日的大鼠给予750mg/kg的N-甲基乙酰胺，出现畸胎。

分子结构数据

1、   摩尔折射率：19.57

2、   摩尔体积（cm³/mol）：83.9

3、   等张比容（90.2K）：184.5

4、   表面张力（dyne/cm）：23.2

5、   极化率（10^-24cm³）：7.75

 

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:1

3.氢键受体数量:1

4.可旋转化学键数量:0

5.互变异构体数量:2

6.拓扑分子极性表面积29.1

7.重原子数量:5

8.表面电荷:0

9.复杂度:42.2

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  N-甲基乙酰胺红外图谱(IR1)
• 
  N-甲基乙酰胺质谱(MS)
• 
  N-甲基乙酰胺核磁图(¹³CNMR)
• 
  N-甲基乙酰胺核磁图(¹HNMR)
• 
  N-甲基乙酰胺Raman光谱