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- 2-氨基-3-[4-[4-[二(2-氯乙基)氨基]苯氧基]苯基]丙酸
2-氨基-3-[4-[4-[二(2-氯乙基)氨基]苯氧基]苯基]丙酸
2-氨基-3-[4-[4-[二(2-氯乙基)氨基]苯氧基]苯基]丙酸 基本信息
- 中文名称：
- 2-氨基-3-[4-[4-[二(2-氯乙基)氨基]苯氧基]苯基]丙酸
- 中文别名：
-
- 英文名称：
- Tyrosine,O-[4-[bis(2-chloroethyl)amino]phenyl]-
- 英文别名：
- 2-amino-3-[4-[4-[bis(2-chloroethyl)amino]phenoxy]phenyl]propanoic acid;
Phentyrin;
Fenitirin
- CAS No.：
- 857-95-4
- 分 子 式：
- C19H22Cl2N2O3
- 分 子 量：
- 397.26
- 精确分子量：
- 396.10100
- PSA：
- 75.79000
- 安全术语：
- A poison by ingestion, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
- 分子结构式：
-
- SDS：
- 查看
2-氨基-3-[4-[4-[二(2-氯乙基)氨基]苯氧基]苯基]丙酸 物化性质
- 密度：
- 1.316g/cm3
- 沸点：
- 562.9ºC at 760 mmHg
- 闪点：
- 294.2ºC
- 折射率：
- 1.614
- 存储条件/存储方法：
- 库房通风低温干燥,与食品原料分开存放
2-氨基-3-[4-[4-[二(2-氯乙基)氨基]苯氧基]苯基]丙酸 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AY3340000
- CHEMICAL NAME :
- Alanine,
3-(p-(p-(bis(2-chloroethyl)amino)phenoxy)phenyl)-,
DL-
- CAS REGISTRY NUMBER :
- 857-95-4
- LAST UPDATED :
- 199807
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C19-H22-Cl2-N2-O3
- MOLECULAR WEIGHT :
- 397.33
- WISWESSER LINE NOTATION :
- QVYZ1R DOR DN2G2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 620 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 115 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 62 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 360 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 120 mg/kg/10D-I
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from large intestine
Blood - changes in bone marrow (not otherwise specified)
Related to Chronic Data - death
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 6 mg/kg/10D-I
- TOXIC EFFECTS :
- Cardiac - EKG changes not diagnostic of specified effects
Kidney, Ureter, Bladder - other changes
Blood - changes in spleen
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,100,1980
