2,4-二溴-6-甲基苯胺

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 海关数据
  • 结构与计算化学
  • 上游产品
  • 下游产品

2,4-二溴-6-甲基苯胺 基本信息

中文名称:
2,4-二溴-6-甲基苯胺 
中文别名:
2,4-二溴-6-甲基苯胺;
6-甲基-2,4-二溴苯胺;
4,6-二溴邻甲基苯胺 
英文名称:
Benzenamine,2,4-dibromo-6-methyl-
英文别名:
2,4-Dibromo-6-methylaniline;
4.6-Dibrom-o-toluidin;
2,3-O-ISOPROPYLIDENE-D-ALLONIC ACID;
3.5-Dibrom-2-amino-toluol;
2,4-dibromo-6-methyl-aniline 
CAS No.:
30273-41-7
分 子 式:
C7H7Br2N
分 子 量:
264.94
精确分子量:
262.89500
PSA:
26.02000
MDL:
MFCD00735681
InChI:
InChI=1/C7H7Br2N/c1-4-2-5(8)3-6(9)7(4)10/h2-3H,10H2,1H3
危险品标志:
风险术语:
R20/21/22;R36/37/38   
安全术语:
S26;S36/37/39
分子结构式:
SDS:
查看

2,4-二溴-6-甲基苯胺 制备方法及用途

制备方法

由邻甲苯胺经溴化而得。将氯仿和邻甲苯胺加入反应锅,于20-25℃滴加溴素,约3-4h加完,然后升温回流10h。冷却,用氨水调至pH9-10,静置分层,收集氯仿层,回收氯仿即得成品。

合成制备方法

由邻甲苯胺经溴化而得。将氯仿和邻甲苯胺加入反应锅,于20-25℃滴加溴素,约3-4h加完,然后升温回流10h。冷却,用氨水调至pH9-10,静置分层,收集氯仿层,回收氯仿即得成品。

用途简介

作医药中间体,用于生产新型祛痰剂溴己胺盐酸盐(必嗽平)。

用途

作医药中间体,用于生产新型祛痰剂溴己胺盐酸盐(必嗽平)。

2,4-二溴-6-甲基苯胺 物化性质

外观与性状:
灰白色至灰色或淡棕色结晶粉末
密度:
1.887g/cm3
熔点:
44-49ºC
沸点:
281.2ºC at 760mmHg
闪点:
123.9ºC
折射率:
1.641
存储条件/存储方法:

  密闭于阴凉干燥环境中

稳定性相关:

 遵照规定使用和储存则不会分解。

其它信息:

1.       性状:针状结晶体

2.       密度(g/mL,25/4℃):无可用

3.       相对蒸汽密度(g/mL,空气=1):无可用

4.       熔点(ºC):44-49

5.       沸点(ºC,常压):无可用

6.       沸点(ºC,5.2kPa):无可用

7.       折射率:无可用

8.       闪点(ºC):无可用

9.       比旋光度(º):无可用

10.    自燃点或引燃温度(ºC):无可用

11.    蒸气压(kPa,25ºC):无可用

12.    饱和蒸气压(kPa,60ºC):无可用

13.    燃烧热(KJ/mol):无可用

14.    临界温度(ºC):无可用

15.    临界压力(KPa):无可用

16.    油水(辛醇/水)分配系数的对数值:无可用

17.    爆炸上限(%,V/V):无可用

18.    爆炸下限(%,V/V):无可用

19.    溶解性:溶于乙醇。可随蒸汽挥发

2,4-二溴-6-甲基苯胺 安全信息

海关代码:
2921430090
危险类别码:
R20/21/22;R36/37/38
安全说明:
36/37/39-26
安全标志:
S26:万一接触眼睛,立即使用大量清水冲洗并送医诊治。
:
危险标志:
Xn: Harmful;

2,4-二溴-6-甲基苯胺 毒理性

生态数据:

 

该物质对环境可能有危害,对水体应给予特别注意。

2,4-二溴-6-甲基苯胺 MSDS

Name: 2 4-Dibromo-6-methylaniline Material Safety Data Sheet
Synonym: 2-Amino-3,5-dibromotoluene4,6-Dibromo-o-toluidin
CAS: 30273-41-7
Section 1 - Chemical Product   MSDS Name:2 4-Dibromo-6-methylaniline Material Safety Data Sheet
Synonym:2-Amino-3,5-dibromotoluene4,6-Dibromo-o-toluidin

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
30273-41-7 2,4-Dibromo-6-methylaniline unlisted
Hazard Symbols: XN
Risk Phrases: 20/21/22 36/37/38

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. Harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
  Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 30273-41-7: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Powder
Color: off-white to brown
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 44-49 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C7H7Br2N
Molecular Weight: 264.95

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen bromide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 30273-41-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2,4-Dibromo-6-methylaniline - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
WGK (Water Danger/Protection)
CAS# 30273-41-7: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 30273-41-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 30273-41-7 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

2,4-二溴-6-甲基苯胺 海关数据

中国海关编码:2921430090

概述:
2921430090 甲苯胺及其衍生物以及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素:
品名, 成分含量, 用途, 原产地证据文件及编号(例 附原产地证书, 原产于欧盟的
摘要/Summary:
HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

2,4-二溴-6-甲基苯胺 分子结构与计算化学数据

分子结构数据

1、   摩尔折射率:50.69

2、   摩尔体积(cm3/mol):140.3

3、   等张比容(90.2K):371.7

4、   表面张力(dyne/cm):49.2

5、   极化率(10-24cm3):20.09

计算化学数据

1.疏水参数计算参考值(XlogP):3

2.氢键供体数量:1

3.氢键受体数量:1

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积26

7.重原子数量:10

8.表面电荷:0

9.复杂度:118

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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上海源叶生物科技有限公司

产品介绍:
产品名称:2,4-二溴-6-甲基苯胺 Cas号:30273-41-7 纯度:98% 包装信息:1g,5g 价格:85.0元 - 120.0元
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郑州杰克斯化工有限公司

产品介绍:
产品名称:2,4-二溴-6-甲基苯胺 Cas号:30273-41-7 纯度: 包装信息:洽谈 价格:洽谈
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联系人:许伟伟 电话:0371-86259281 15981966935 手机:15981966935