二硫代苏糖醇; DTT

  • 基本信息
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 海关数据
  • 结构与计算化学
  • 下游产品
  • 表征图谱

二硫代苏糖醇; DTT 基本信息

中文名称:
二硫代苏糖醇; DTT 
中文别名:
二硫代苏糖醇;
1,4-二硫代苏糖醇;
DTT;
二硫苏糖醇;
DL-1,4-二硫苏糖醇;
1,4-二硫-DL-苏糖醇;
(+/-)-二硫苏糖醇;
1,4二巯基苏糖醇DTT;
DL-二硫苏糖醇 
英文名称:
DL-Dithiothreitol
英文别名:
DL-Dithiothreitol;
Dithiothreitol 
CAS No.:
27565-41-9
分 子 式:
C4H10O2S2
分 子 量:
154.24
精确分子量:
154.01200
PSA:
118.06000
EINECS:
222-468-7
InChI:
The Key: VHJLVAABSRFDPM-UHFFFAOYSA-N
分子结构式:
SDS:
查看

二硫代苏糖醇; DTT 物化性质

外观与性状:
白色粉末
密度:
1.04 g/mL at 20 °C
熔点:
41-44 °C(lit.)
沸点:
125-130 °C (2 mmHg)
闪点:
>230 °F
水溶解性:
Soluble
折射率:
1.576
存储条件/存储方法:

2-8

稳定性相关:

常温常压下稳定

其它信息:

1.       性状:未确定

2.       密度(g/mL,25/4℃):1.04

3.       相对蒸汽密度(g/mL,空气=1):未确定

4.       熔点(ºC):41-44

5.       沸点(ºC,2mmhg):125-130

6.       沸点(ºC,5.2kPa):未确定

7.       折射率:未确定

8.       闪点(ºF):>230

9.       比旋光度(º):未确定

10.    自燃点或引燃温度(ºC):未确定

11.    蒸气压(kpa,20ºC):未确定

12.    饱和蒸气压(kPa,60ºC):未确定

13.    燃烧热(KJ/mol):未确定

14.    临界温度(ºC):未确定

15.    临界压力(KPa):未确定

16.    油水(辛醇/水)分配系数的对数值:未确定

17.    爆炸上限(%,V/V):未确定

18.    爆炸下限(%,V/V):未确定

19.    溶解性:未确定

二硫代苏糖醇; DTT 安全信息

海关代码:
2930909090
WGK_Germany:
3
德国有关水污染物质的分类清单
危险类别码:
25-36/37/38-22-20/21/22
安全说明:
S26-S45
RTECS号:
EK1610000
危险标志:
Xn

二硫代苏糖醇; DTT 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XO8576500
CHEMICAL NAME :
Threitol, 1,4-dithio-, DL-
CAS REGISTRY NUMBER :
27565-41-9
BEILSTEIN REFERENCE NO. :
1719757
LAST UPDATED :
199806
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C4-H10-O2-S2
MOLECULAR WEIGHT :
154.26
WISWESSER LINE NOTATION :
SH1YQYQ1SH -DL, THREO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
169 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
333 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
94 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
1 mmol/L
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 166,400,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2950 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 627 (estimated) No. of Female Employees: 436 (estimated)
毒理学数据:

1、急性毒性:小鼠腹腔LD50169mg/kg;小鼠皮下LD50333mg/kg小鼠静脉LD5094 mg/kg;

二硫代苏糖醇; DTT MSDS

Name: DL-Dithiothreitol DNase RNase Protease Free Material Safety Data Sheet
Synonym: Cleland's Reagent; Threo-1,4-Dimercapto-2,3-Butanediol; DTT
CAS: 27565-41-9
Section 1 - Chemical Product   MSDS Name:DL-Dithiothreitol DNase RNase Protease Free Material Safety Data Sheet
Synonym:Cleland's Reagent; Threo-1,4-Dimercapto-2,3-Butanediol; DTT

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
27565-41-9 DL-Dithiothreitol, DNase, RNase, Prote 99.4% 248-531-9
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Dusts may be combustible when exposed to heat, flame, or oxidizing agents.
Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam. Use agent most appropriate to extinguish fire.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Keep refrigerated. (Store below 4C/39F.)

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 27565-41-9: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 42.00 - 44.
Autoignition Temperature: Not available.
Flash Point: > 110 deg C (> 230.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: freely soluble in ethanol, acetone, ethe
Specific Gravity/Density:
Molecular Formula: HSCH2CH(OH)CH(OH)CH2SH
Molecular Weight: 154.24

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Alkali metals, bases, reducing agents, oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of sulfur, carbon dioxide, hydrogen sulfide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 27565-41-9: XO8576500 LD50/LC50:
Not available.
Carcinogenicity:
DL-Dithiothreitol, DNase, RNase, Protease Free - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 27565-41-9: No information available.
Canada
CAS# 27565-41-9 is listed on Canada's DSL List.
CAS# 27565-41-9 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 27565-41-9 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

二硫代苏糖醇; DTT 海关数据

中国海关编码:2930909090

概述:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素:
品名, 成分含量, 用途
摘要/Summary:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

二硫代苏糖醇; DTT 分子结构与计算化学数据

分子结构数据

1   摩尔折射率:39.36

2   摩尔体积m3/mol118.4

3   等张比容(90.2K):323.2

4   表面张力dyne/cm55.5

5   极化率10-24cm315.60

计算化学数据

1、   疏水参数计算参考值(XlogP):-0.4

2、   氢键供体数量:2

3、   氢键受体数量:2

4、   可旋转化学键数量:3

5、   拓扑分子极性表面积(TPSA):40.5

6、   重原子数:8

7、   表面电荷:0

8、   复杂度:52

9、   同位素原子数量:0

10、           确定原子立构中心数量:2

11、           不确定原子立构中心数量:0

12、           确定化学键立构中心数量:0

13、           不确定化学键立构中心数量:0

14、           共价键单元数量:1

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