Section I.Chemical Product and Company Identification
Chemical Name Corticosterone 21-Acetate
Portland OR
Synonym Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11-
hydroxy-, (11-beta)- (9 CI)
Chemical Formula C23H32O5
CAS Number 1173-26-8
Section II. Composition and Information on Ingredients
Toxicology Data
Chemical Name CAS Number Percent (%) TLV/PEL
Corticosterone 21-Acetate Min. Not available. Not available.
1173-26-8
98.0(HPLC)
Section III. Hazards Identification
Acute Health Effects No specific information is available in our data base regarding the toxic effects of this material for humans. However,
exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling
this compound. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this
compound.
Chronic Health Effects CARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: REPRODUCTIVE EFFECTS:
Rat TDLo (intraperitoneal) 250mg/kg, female, 3 Days prior to mating.
Toxic Effects:
Maternal Effects- Ovaries, fallopian tubes.
Maternal Effects- Uterus, cervix, vagina.
Maternal Effects- Menstrual cycle changes or disorders.
Rat TDLo (intraperitoneal) 250mg/kg, male, 1 Day prior to mating.
Toxic Effects:
Paternal Effects- Testes, epididymis, sperm duct.
Mouse TDLo (subcutaneous) 7200mg/kg, female, 11-14 Days of pregnancy.
Toxic Effects:
Effects on Fertility- Post-implantation mortality.
Effects on Embryo or Fetus- Fetotoxicity.
Specific Developmental Abnormalities- Craniofacial.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
Section IV. First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Get medical attention.
Skin Contact
In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
Inhalation
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
Ingestion INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the
toxic material was ingested; the absence of such signs, however, is not conclusive.
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Corticosterone 21-Acetate
Section V. Fire and Explosion Data
Not available.
Flammability May be combustible at high temperature. Auto-Ignition
Flash Points Flammable Limits
Not available. Not available.
Combustion Products
These products are toxic carbon oxides (CO, CO 2).
Fire Hazards
Not available.
Explosion Hazards Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.
Section VI. Accidental Release Measures
Spill Cleanup Light sensitive material.
Instructions Use a shovel to put the material into a convenient waste disposal container. Finish cleaning the spill by rinsing any
contaminated surfaces with copious amounts of water. Consult federal, state, and/or local authorities for assistance on
disposal.
Section VII. Handling and Storage
Handling and Storage LIGHT SENSITIVE. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and
store in a dry, cool place. Avoid excessive heat and light. Do not breathe dust.
Information
Always store away from incompatible compounds such as oxidizing agents.
Section VIII. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Splash goggles. Lab coat. Dust respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult
a specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
Exposure Limits Not available.
Section IX. Physical and Chemical Properties
Solubility
Physical state @ 20°C Solid. (White powder.) Not available.
Not available.
Specific Gravity
Molecular Weight 388.50 Partition Coefficient Not available.
Boiling Point
Not available. Vapor Pressure Not applicable.
Melting Point 145 to 146°C (293 to 294.8°F) Vapor Density Not available.
Refractive Index Not available. Volatility Not available.
Critical Temperature Not available. Odor Not available.
Viscosity Not available. Taste Not available.
Section X. Stability and Reactivity Data
Stability
This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of Instability Light sensitive. Avoid excessive heat and light.
Incompatibilities
Reactive with oxidizing agents.
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Corticosterone 21-Acetate
Section XI. Toxicological Information
RTECS Number GM7820000
Routes of Exposure Eye Contact. Ingestion. Inhalation.
Toxicity Data Not available.
CARCINOGENIC EFFECTS : Not available.
Chronic Toxic Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: REPRODUCTIVE EFFECTS:
Rat TDLo (intraperitoneal) 250mg/kg, female, 3 Days prior to mating.
Toxic Effects:
Maternal Effects- Ovaries, fallopian tubes.
Maternal Effects- Uterus, cervix, vagina.
Maternal Effects- Menstrual cycle changes or disorders.
Rat TDLo (intraperitoneal) 250mg/kg, male, 1 Day prior to mating.
Toxic Effects:
Paternal Effects- Testes, epididymis, sperm duct.
Mouse TDLo (subcutaneous) 7200mg/kg, female, 11-14 Days of pregnancy.
Toxic Effects:
Effects on Fertility- Post-implantation mortality.
Effects on Embryo or Fetus- Fetotoxicity.
Specific Developmental Abnormalities- Craniofacial.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
Acute Toxic Effects No specific information is available in our data base regarding the toxic effects of this material for humans. However,
exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling
this compound. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this
compound.
Section XII. Ecological Information
Ecotoxicity Not available.
Environmental Fate Not available.
Section XIII. Disposal Considerations
Waste Disposal Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.
Section XIV. Transport Information
DOT Classification Not a DOT controlled material (United States).
PIN Number Not applicable.
Proper Shipping Name
Not applicable.
Packing Group (PG) Not applicable.
DOT Pictograms
Section XV. Other Regulatory Information and Pictograms
TSCA Chemical Inventory This product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
CFR 720.36 (C) for those products not on the inventory list:
(EPA)
(i) These products are supplied solely for use in research and development by or under the supervision of a technically
qualified individual as defined in 40 CFR 720.0 et sec.
(ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
supplied on an MSDS sheet.
WHMIS Classification Not available.
(Canada)
EINECS Number (EEC) 214-635-8
EEC Risk Statements
Not available.
Japanese Regulatory Data Not available.
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SECTION 16 - ADDITIONAL INFORMATION
N/A
