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氢吗啡酮
- 基本信息
- 物化性质
- 安全信息
- 毒理性
- 结构与计算化学
- 上游产品
- 下游产品
氢吗啡酮 基本信息
- 中文名称:
- 氢吗啡酮
- 中文别名:
- 氢吗啡酮;
二氫嗎啡酮
- 英文名称:
- HYDROMORPHONE
- 英文别名:
- hydromorphone;
Dihydromorphinone;
Dimorphone;
Hydromorphon;
Hidromorfona;
Dihydromorfinon;
Idromorfone;
DiMo;
Dilaudid;
Laudacon;
(4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one
- CAS No.:
- 466-99-9
- 分 子 式:
- C17H19NO3
- 分 子 量:
- 285.34
- 精确分子量:
- 285.13600
- PSA:
- 49.77000
- EINECS:
- 207-383-5
- InChI:
- InChI=1/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1
- 风险术语:
- 11-23/24/25-39/23/24/25
- 分子结构式:
-
- SDS:
- 查看
氢吗啡酮 物化性质
- 密度:
- 1.4g/cm3
- 沸点:
- 475.6ºC at 760mmHg
- 闪点:
- 241.4ºC
- 折射率:
- 1.678
- 蒸汽压:
- 1.14E-09mmHg at 25°C
氢吗啡酮 安全信息
- 包装等级:
- II
- 风险类别:
- 6.1(a)
- 海关代码:
- 2939110014
氢吗啡酮 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QD2500000
- CHEMICAL NAME :
- Morphinan-6-one, 4,5-alpha-epoxy-3-hydroxy-17-methyl-
- CAS REGISTRY NUMBER :
- 466-99-9
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C17-H19-N-O3
- MOLECULAR WEIGHT :
- 285.37
- WISWESSER LINE NOTATION :
- T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ JQ P1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 1428 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,223,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 84 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - stiffness
Behavioral - muscle contraction or spasticity
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 52,468,1934
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 104 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - local anesthetic
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-
Volume(issue)/page/year: 84,268,1964
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6130
No. of Facilities: 16 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 3537 (estimated)
No. of Female Employees: 3487 (estimated)
氢吗啡酮 分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值(XlogP):1.8
2.氢键供体数量:1
3.氢键受体数量:4
4.可旋转化学键数量:0
5.互变异构体数量:6
6.拓扑分子极性表面积:49.8
7.重原子数量:21
8.表面电荷:0
9.复杂度:494
10.同位素原子数量:0
11.确定原子立构中心数量:4
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1