洛克沙生

外观与性状：

淡黄色晶体或淡黄褐色的粉末

密度：

2.02 g/cm3

熔点：

≥300 °C(lit.)

沸点：

537.3±60.0 °C

闪点：

240.3±21.3 °C

水溶解性：

Slightly Soluble (2.2 g/L)

蒸汽压：

2.24E-12mmHg at 25°C

蒸汽密度：

2.24E-12 Torr

存储条件/存储方法：

库房通风低温干燥,与食品原料分开储运

稳定性相关：

一、基本性质

   白色或浅黄色针状或菱片状结晶。易溶于甲醇、乙醇、乙酸、丙酮和碱，溶于约30份沸水，微溶于冷水，极微溶于稀矿酸，不溶于乙醚和乙酸乙酯。熔点≥300℃。有毒，半数致死量（大鼠，经口）155mg/kg。

其它信息：

1.          性状：白色或浅黄色针状或菱片状结晶

2.         熔点（℃）：>300

3.         水溶性（g/100mL ,23°C）：<0.1

4.          毒性：有毒

包装等级：

III

风险类别：

6.1(b)

海关代码：

2931900029

WGK_Germany：

3
德国有关水污染物质的分类清单

危险类别码：

R23/25;R50/53

安全说明：

20/21-28-45-60-61

RTECS号：

CY5250000

安全标志：

S28:接触皮肤之后，立即使用大量皂液洗涤。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S60:本物质残余物和容器必须作为危险废物处理。
S61:避免排放到环境中。参考专门的说明/安全数据表。

危险标志：

T:Toxic;N:Dangerousfortheenvironment;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

CY5250000

CHEMICAL NAME :

Benzenearsonic acid, 4-hydroxy-3-nitro-

CAS REGISTRY NUMBER :

121-19-7

BEILSTEIN REFERENCE NO. :

1976533

LAST UPDATED :

199701

DATA ITEMS CITED :

44

MOLECULAR FORMULA :

C6-H6-As-N-O6

MOLECULAR WEIGHT :

263.05

WISWESSER LINE NOTATION :

WNR BQ E-AS-QQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

81 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

66 mg/kg

TOXIC EFFECTS :

Behavioral - muscle weakness Gastrointestinal - other changes Kidney, Ureter, Bladder - interstitial nephritis

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

244 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

50 mg/kg

TOXIC EFFECTS :

Gastrointestinal - nausea or vomiting Liver - hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Bird - chicken

DOSE/DURATION :

110 mg/kg

TOXIC EFFECTS :

Gastrointestinal - other changes Blood - hemorrhage

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Bird - chicken

DOSE/DURATION :

34 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Liver - hepatitis (hepatocellular necrosis), diffuse

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Bird - turkey

DOSE/DURATION :

61 mg/kg

TOXIC EFFECTS :

Gastrointestinal - other changes Blood - hemorrhage

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2647 mg/kg/13W-C

TOXIC EFFECTS :

Behavioral - food intake (animal) Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

11200 mg/kg/14D-C

TOXIC EFFECTS :

Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1680 mg/kg/14D-C

TOXIC EFFECTS :

Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

8736 mg/kg/13W-C

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - bronchiolar dilation Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Bird - chicken

DOSE/DURATION :

3625 mg/kg/13W-C

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in bladder weight Blood - hemorrhage Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Bird - turkey

DOSE/DURATION :

2019 mg/kg/36D-C

TOXIC EFFECTS :

Peripheral Nerve and Sensation - structural change in nerve or sheath Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2920 mg/kg/2Y-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

MUTATION DATA

TYPE OF TEST :

Mutation in mammalian somatic cells

TEST SYSTEM :

Rodent - mouse Lymphocyte

DOSE/DURATION :

400 mg/L

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-345,1989 *** REVIEWS *** TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: As,-,1977 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.5 mg(As)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,16,1971 OSHA PEL (Gen Indu):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.2 mg(As)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.05 mg(As)/m3;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.2 mg(As)/m3 JAN 1993 OEL-DENMARK:TWA 0.05 mg(As)/m3 JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.2 mg(As)/m3 JAN 1993 OEL-HUNGARY:STEL 0.5 mg(As)/m3;Carcinogen JAN 1993 OEL-INDIA:TWA 0.2 mg(As)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 mg(As)/m3 JAN 1993 OEL-POLAND:TWA 0.3 mg(As)/m3 JAN 1993 OEL-SWEDEN:TWA 0.03 mg(As)/m3;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(As)/m3;Carcinogen JAN 1993 OEL-THAILAND:TWA 0.5 mg(As)/m3 JAN 1993 OEL-TURKEY:TWA 0.5 mg(As)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 mg(As)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0637 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 124 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0637 No. of Facilities: 210 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 3230 (estimated)

中国海关编码：2931900029

概述：

2931900029 3-硝基-4-羟基苯胂酸〔4-羟基-3-硝基苯胂酸〕。监管条件:X(有毒化学品环境管理放行通知单)。增值税率:17.0%。退税率:0.0%。最低关税:6.5%。普通关税:30.0%

摘要/Summary：

2931900029 (4-hydroxy-3-nitrophenyl)arsonic acid。supervision conditions:x(environment control release notice for poisonous chemicals)。VAT:17.0%。tax rebate rate:0.0%。MFN tarrif:6.5%。general tariff:30.0%

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:3

3.氢键受体数量:6

4.可旋转化学键数量:1

5.互变异构体数量:4

6.拓扑分子极性表面积124

7.重原子数量:14

8.表面电荷:0

9.复杂度:270

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  4-羟基-3-硝基苯胂酸红外图谱(IR1)
• 
  4-羟基-3-硝基苯胂酸红外图谱(IR2)
• 
  4-羟基-3-硝基苯胂酸质谱(MS)
• 
  4-羟基-3-硝基苯胂酸核磁图(¹³CNMR)
• 
  4-羟基-3-硝基苯胂酸核磁图(¹HNMR)