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甘露醇氮芥 基本信息
- 中文名称：
- 甘露醇氮芥
- 中文别名：
- 甘露醇氮芥;
甘露莫司汀
- 英文名称：
- mannomustine
- 英文别名：
- (2R,3R,4R,5R)-1,6-bis(2-chloroethylamino)hexane-2,3,4,5-tetrol;
Mannit-lost [German];
Mannomustin;
Mannitol nitrogen mustard;
Manomustina [INN-Spanish];
Mannomustine [INN:BAN:DCF];
Mannit-mustard [German];
Mannit-Lost;
Mannomustinum [INN-Latin];
1,6-Bis-<(2-chlorethyl)-amino>-1,6-dideoxy-D-mannitol;
1,6-Bis-(2-chlor-aethylamino)-1,6-didesoxy-D-mannit;
BCM (cytostatic);
mannomustine;
1,6-bis-(2-chloro-ethylamino)-1,6-dideoxy-D-mannitol;
1,6-Bis-<2-chlor-ethylamino>-1,6-didesoxy-D-mannit
- CAS No.：
- 576-68-1
- 分 子 式：
- C10H22Cl2N2O4
- 分 子 量：
- 0
- 精确分子量：
- 304.09600
- PSA：
- 104.98000
- EINECS：
- 209-404-3
- InChI：
- The Key: MQXVYODZCMMZEM-ZYUZMQFOSA-N
- 分子结构式：
-
- SDS：
- 查看
甘露醇氮芥 物化性质
- 密度：
- 1.353g/cm3
- 沸点：
- 541.9ºC at 760 mmHg
- 闪点：
- 281.5ºC
- 折射率：
- 1.544
甘露醇氮芥 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OP2100000
- CHEMICAL NAME :
- Mannitol, 1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-,
D-,
- CAS REGISTRY NUMBER :
- 576-68-1
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C10-H22-Cl2-N2-O4
- MOLECULAR WEIGHT :
- 305.24
- WISWESSER LINE NOTATION :
- G2M1YQYQYQYQ1M2G -D
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Blood - changes in spleen
Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Blood - leukopenia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Blood - changes in spleen
Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Sister chromatid exchange
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Cells - not otherwise specified
- DOSE/DURATION :
- 2900 nmol/L
- REFERENCE :
- SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
18,210,1982
