疣孢菌素A

密度：

1.32g/cm3

熔点：

>360ºC

沸点：

747.4ºC at 760mmHg

闪点：

250.2ºC

折射率：

1.584

包装等级：

I

风险类别：

6.1(a)

WGK_Germany：

3
德国有关水污染物质的分类清单

危险类别码：

26/27/28

RTECS号：

WH1314900

危险标志：

T+: Very toxic;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

WH1314900

CHEMICAL NAME :

Spiro(16,18-methano-1H,3H,23H-(1,6,12)trioxacycloocta decino(3,4-d)(1)benzo pyran-17(18H),2'- oxirane)-3,9,14-trione, 4,5,6,7,16,16a,19a,22-octahydro-4-hydroxy-5,16a,21-tr imethyl-, stereoisomer

CAS REGISTRY NUMBER :

3148-09-2

LAST UPDATED :

199209

DATA ITEMS CITED :

9

MOLECULAR FORMULA :

C27-H34-O9

MOLECULAR WEIGHT :

502.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - guinea pig

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

870 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

500 ug/kg

TOXIC EFFECTS :

Skin and Appendages - dermatitis, other (after systemic exposure) Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

3900 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1500 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

540 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

14 mg/kg/8W-C

TOXIC EFFECTS :

Blood - changes in leukocyte (WBC) count

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

5 mg/kg/50D-C

TOXIC EFFECTS :

Blood - leukopenia Blood - changes in cell count (unspecified) Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :

DNA inhibition

TEST SYSTEM :

Rodent - mouse Lymphocyte

DOSE/DURATION :

1 nmol/L

REFERENCE :

PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 34,231,1978