首页产品供求市场行情现货直销公司信息
产品
产品 公司 求购 资讯 法规
English
  1. 您当前位置：
  2. 首页
  3. 产品数据
  4. 二嗪磷

二嗪磷

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 海关数据
  • 结构与计算化学
  • 上游产品
  • 下游产品
  • 表征图谱

二嗪磷 基本信息

中文名称：
二嗪磷 
中文别名：
二嗪磷;
0,0-二乙基-0-(2-异丙基-4-甲嘧啶-6-甲)硫逐磷酸酯;
O,O-二乙基-O-(2-异丙基-4-甲基嘧啶-6-基)硫代磷酸酯;
二嗪农;
敌匹硫磷;
大亚仙农;
地亚农 
英文名称：
Diazinon
英文别名：
diazinon;
Diazinon AG500;
O,O-diethyl O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] phosphorothioate;
Antlak;
Anti;
O,O-diethyl O-2-isopropyl-6-methylpyrimidin-4-yl phosphorothioate;
Dicid;
Exodin;
dimpylate;
Dazzel;
dyzol;
G 301;
pt265;
Diazinon;
O,O-diethyl O-[6-methyl-2-(propan-2-yl)pyrimidin-4-yl] phosphorothioate;
AG-500 
CAS No.：
333-41-5
分 子 式：

C12H21N2O3PS

分 子 量：
304.34
精确分子量：
304.10100
PSA：
95.37000
MDL：
MFCD00036204
EINECS：
206-373-8
BRN：
273790
InChI：
InChI=1/C4H4N2O/c7-4-2-1-3-5-6-4/h1-3H,(H,6,7)
危险品标志：

Xn:
N :
 

风险术语：

R22;R50/53;

安全术语：

S24/25;S60;S61;

分子结构式：
SDS：
查看

二嗪磷 制备方法及用途

制备方法

1.将甲醇、氯化氢与异丁腈反应生成相应的亚氨酸酯盐酸盐;用氨处理,转化成相应的脒。然后,在碱性条件下,脒同乙酰乙酸乙酯缩合,得到嘧啶醇(4-羟基-2-异丙基-6-甲基嘧啶)。嘧啶醇在苯或甲苯中,在碳酸钠存在下加热回流,加入二乙基硫代磷酰氯、硝酸铜,缩合得到二嗪农。 2.将甲醇、氯化氢与异丁腈反应生成相应的亚氨酸酯盐酸盐;用氨处理得到异丁脒,在碱性条件下,异丁脒同乙酰乙酸乙酯缩合,得到嘧啶醇(4-羟基-2-异丙基-6-甲基嘧啶)。嘧啶醇在苯或甲苯中,在碳酸钠存在下加热回流,加入二乙基硫代磷酰氯、硝酸铜,缩合得到二嗪磷。 3.0,O一二乙基硫代磷醚氯的制备详见哇硫磷的合成。2一异丙基一4一甲基一6-羟基嘧啶的制备由异丁睛与甲醉和盐酸反应,制得业胺醚盐酸盐,再与氦作用制得异丁眯。异丁眯与乙醚乙酸乙酯在氢氧化钠存在下环化制得2一异丙基一4一甲基一6-羟基嘧啶。 4.二嚓磷的合成将撇2一异丙基一4一甲基一6-羟基嘧啶,0.638 SMB,2.828氢氧化钠、SOm工一丁酮混合后,在室温下搅拌O.Sh,缓慢升温至55 (' ,至物料澄清后加入9.5} O,O一二乙基硫代磷k4}氯,并升温至70 (' >搅拌O.Sh,再回流1h,搅冷,加入SOm工_水,使析出固体洛解,用20 0/} NaOH调竹pH值至11,搅拌、分层。水层用丁酮萃取,洛剂合并,减压脱洛,残留物经碱洗、酸洗、再碱洗后,水洗至中性,减压加热脱水,得14g棕色透明液液体,折射率1.49420

合成制备方法

1.将甲醇、氯化氢与异丁腈反应生成相应的亚氨酸酯盐酸盐；用氨处理，转化成相应的脒。然后，在碱性条件下，脒同乙酰乙酸乙酯缩合，得到嘧啶醇（4-羟基-2-异丙基-6-甲基嘧啶）。嘧啶醇在苯或甲苯中，在碳酸钠存在下加热回流，加入二乙基硫代磷酰氯、硝酸铜，缩合得到二嗪农。

2.将甲醇、氯化氢与异丁腈反应生成相应的亚氨酸酯盐酸盐；用氨处理得到异丁脒，在碱性条件下，异丁脒同乙酰乙酸乙酯缩合，得到嘧啶醇（4-羟基-2-异丙基-6-甲基嘧啶）。嘧啶醇在苯或甲苯中，在碳酸钠存在下加热回流，加入二乙基硫代磷酰氯、硝酸铜，缩合得到二嗪磷。

3.0,O一二乙基硫代磷醚氯的制备详见哇硫磷的合成。2一异丙基一4一甲基一6-羟基嘧啶的制备由异丁睛与甲醉和盐酸反应，制得业胺醚盐酸盐，再与氦作用制得异丁眯。异丁眯与乙醚乙酸乙酯在氢氧化钠存在下环化制得2一异丙基一4一甲基一6-羟基嘧啶。

4.二嚓磷的合成将撇2一异丙基一4一甲基一6-羟基嘧啶 ，0.638 SMB,2.828氢氧化钠、SOm工一丁酮混合后，在室温下搅拌O.Sh,缓慢升温至55 (' ,至物料澄清后加入9.5} O,O一二乙基硫代磷k4}氯，并升温至70 (' >搅拌O.Sh，再回流1h,搅冷，加入SOm工_水，使析出固体洛解，用20 0/} NaOH调竹pH值至11,搅拌、分层。水层用丁酮萃取，洛剂合并，减压脱洛，残留物经碱洗、酸洗、再碱洗后，水洗至中性，减压加热脱水，得14g棕色透明液液体，折射率1.49420

用途简介

1.是非内吸性杀虫剂,具有一定的杀螨作用。主要用于水稻、果树、葡萄、甘蔗、玉米、烟草和园艺植物上的食叶和刺吸式口器害虫 2.广谱性有机磷杀虫剂,具有触杀、胃毒、熏蒸作用,也有较好的杀螨与杀卵作用。用于防治苹果蠹虫,效果同对硫磷。防治蛴螬或金针虫比对硫磷更有效。除当作一般的触杀药剂以外,还可注射牛体,能灭杀牛瘤蝇的幼虫。对牲畜的毒性较小。可加工成可湿性粉剂、乳剂和粉剂使用。除含铜杀菌剂、碱性农药外,可与大多数农药混用。

用途

1.是非内吸性杀虫剂，具有一定的杀螨作用。主要用于水稻、果树、葡萄、甘蔗、玉米、烟草和园艺植物上的食叶和刺吸式口器害虫

2.广谱性有机磷杀虫剂，具有触杀、胃毒、熏蒸作用，也有较好的杀螨与杀卵作用。用于防治苹果蠹虫，效果同对硫磷。防治蛴螬或金针虫比对硫磷更有效。除当作一般的触杀药剂以外，还可注射牛体，能灭杀牛瘤蝇的幼虫。对牲畜的毒性较小。可加工成可湿性粉剂、乳剂和粉剂使用。除含铜杀菌剂、碱性农药外，可与大多数农药混用。

二嗪磷 物化性质

外观与性状：
淡暗棕色液体
密度：
1.117
熔点：
>120°C (dec.)
沸点：
306°C
闪点：
104.4 °C
水溶解性：
Slightly soluble. 0.004 g/100 mL
折射率：
1.595
存储条件/存储方法：
库房通风低温干燥,与食品原料分开储运
稳定性相关：

对家兔皮肤和眼睛有轻度刺激作用。在试验剂量下，对动物无致畸、致癌、致突变作用。

其它信息：

一、物性数据

性状：无色油状物

密度（g/mL,25/4℃）：1.116-1.118

相对蒸汽密度（g/mL,空气=1）：不可用

熔点（ºC）：不可用

沸点（ºC,常压）：83-84

沸点（ºC,5.2kPa）： 不可用

折射率： 1.498

闪点（ºC）： 不可用

比旋光度（º）： 不可用

自燃点或引燃温度（ºC）： 不可用

蒸气压（kPa,25ºC）： 18700

饱和蒸气压（kPa,60ºC）： 不可用

燃烧热（KJ/mol）：不可用

临界温度（ºC）： 不可用

临界压力（KPa）： 不可用

油水（辛醇/水）分配系数的对数值：不可用 

爆炸上限（%,V/V）：不可用

爆炸下限（%,V/V）： 不可用

溶解性：室温下，水中溶解度为40mg/L(40ppm)，可与乙醇、丙酮、二甲苯混溶，可溶于甘油

二嗪磷 安全信息

包装等级：
III
风险类别：
6.1(b)
海关代码：
2933599011
危险类别码：
R22;R50/53
安全说明：
S24/25-S60-S61-S36-S26-S16
RTECS号：
TF3325000
安全标志：
S60:本物质残余物和容器必须作为危险废物处理。
S61:避免排放到环境中。参考专门的说明/安全数据表。
S24/25:防止皮肤和眼睛接触。
危险标志：
Xn:Harmful

二嗪磷 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TF3325000
CHEMICAL NAME :
Phosphorothioic acid, O,O-diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) ester
CAS REGISTRY NUMBER :
333-41-5
BEILSTEIN REFERENCE NO. :
0273790
LAST UPDATED :
199712
DATA ITEMS CITED :
99
MOLECULAR FORMULA :
C12-H21-N2-O3-P-S
MOLECULAR WEIGHT :
304.38
WISWESSER LINE NOTATION :
T6N CNJ BY1&1 DOPS&O2&O2 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
214 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Skin and Appendages - sweating
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
66 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3500 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2750 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
33 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
58 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - reactivates cholinesterase
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
143 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
633 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
5500 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - pigeon
DOSE/DURATION :
3160 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
8400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
4210 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
3500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
76 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
201 ug/m3/24H/13W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
46 mg/kg/92D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
86 mg/kg/30D-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
91 mg/kg/26W-C
TOXIC EFFECTS :
Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
371 mg/kg/14D-C
TOXIC EFFECTS :
Blood - change in clotting factors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28 mg/kg/28W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1095 mg/kg/2Y-C
TOXIC EFFECTS :
Endocrine - changes in thyroid weight Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
98 mg/kg/28W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
26280 mg/kg/2Y-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
4900 mg/kg/35W-I
TOXIC EFFECTS :
Gastrointestinal - other changes Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1200 mg/kg/46W-I
TOXIC EFFECTS :
Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
157 mg/kg/12W-C
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
3395 mg/kg/1Y-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
210 mg/kg/21D-I
TOXIC EFFECTS :
Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
2450 mg/kg/35W-I
TOXIC EFFECTS :
Gastrointestinal - other changes Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
26400 ug/kg
SEX/DURATION :
female 12-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
45 mg/kg
SEX/DURATION :
female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
63500 ug/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
100 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
150 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
200 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3960 ug/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - delayed effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
189 mg/kg
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - endocrine system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3780 ug/kg
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
210 ug/kg
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system Reproductive - Effects on Newborn - delayed effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
189 mg/kg
SEX/DURATION :
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
130 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
570 mg/kg
SEX/DURATION :
female 1-16 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
DNA inhibition
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,277,1979 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.1 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued. Volume(issue)/page/year: #73-19,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966- Volume(issue)/page/year: 10(3),43,1975 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.1 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,780,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.1 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.1 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 0.1 mg/m3;STEL 0.3 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 0.1 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 0.1 mg/m3;Skin JAN 1993 OEL-HUNGARY:STEL 0.1 mg/m3;Skin JAN 1993 OEL-INDIA:TWA 0.1 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 mg/m3;Skin JAN 1993 OEL-RUSSIA:STEL 0.2 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 mg/m3;STEL 0.3 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIAZINON-air:10H TWA 0.1 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 23360 No. of Facilities: 1268 (estimated) No. of Industries: 9 No. of Occupations: 9 No. of Employees: 26581 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 23360 No. of Facilities: 3168 (estimated) No. of Industries: 10 No. of Occupations: 18 No. of Employees: 39342 (estimated) No. of Female Employees: 3216 (estimated)
毒理学数据：

二、毒理学数据：

急性毒性：LD50：76 mg/kg(大鼠经口)；85 mg/kg(小鼠经口) 。

生态数据：

三、生态学数据：

1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。

二嗪磷 海关数据

中国海关编码：2933599011

概述：
2933599011 嘧啶磷,甲基嘧啶磷,二嗪磷，双苯嘧草酮等〔包括嘧啶氧磷,乙嘧硫磷〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%
申报要素：
品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
监管条件：
S.进出口农药登记证明
摘要/Summary：
2933599011 o-(2-(diethylamino)-6-methylpyrimidin-4-yl) o,o-dimethyl phosphorothioate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

二嗪磷 分子结构与计算化学数据

分子结构数据

1、   摩尔折射率：79.64

2、   摩尔体积（cm3/mol）：260.4

3、   等张比容（90.2K）：677.2

4、   表面张力（dyne/cm）：45.6

5、   极化率（10-24cm3）：31.57

 

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:6

4.可旋转化学键数量:7

5.互变异构体数量:3

6.拓扑分子极性表面积85.6

7.重原子数量:19

8.表面电荷:0

9.复杂度:307

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

推荐供应商更多供应商>>

湖北诺纳科技有限公司
产品介绍：
产品名称：二嗪农 Cas号：333-41-5 纯度：99% 包装信息：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶 价格：1.0元 - 25.0元
联系方式：
联系人：张经理 电话：027-59209883 手机：17386169806

湖北万得化工有限公司
产品介绍：
产品名称：二嗪磷 Cas号：333-41-5 纯度：99% 包装信息：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶,200kg镀锌铁桶/塑料桶,1t吨袋 价格：1.0元 - 1,000.0元
联系方式：
联系人：王念 电话：027-59210159 手机：15172311821

湖北齐飞医药化工有限公司
产品介绍：
产品名称：二嗪农 Cas号：333-41-5 纯度：99% 包装信息：25kg纸板桶/编织袋/塑料桶 价格：25.0元
联系方式：
联系人：朱梦蝶 电话：027-59322506 手机：18071128683

湖北实顺生物科技有限公司
产品介绍：
产品名称：二嗪农 Cas号：333-41-5 纯度：99% 包装信息：25kg纸板桶/编织袋/塑料桶 价格：25.0元
联系方式：
联系人：张经理 电话：027-59223025 手机：15172526927

湖北永阔科技有限公司
产品介绍：
产品名称：二嗪农 Cas号：333-41-5 纯度：99% 包装信息：25kg纸板桶/编织袋/塑料桶 价格：25.0元
联系方式：
联系人：徐 电话：027-59223108 手机：15107166787

天门恒昌化工有限公司
产品介绍：
产品名称：二嗪农 Cas号：333-41-5 纯度：99% 包装信息：25kg纸板桶/编织袋/塑料桶 价格：25.0元
联系方式：
联系人：黄经理 电话：027-59322316 手机：15827039378

湖北信康医药化工有限公司
产品介绍：
产品名称：二嗪磷 Cas号：333-41-5 纯度：99% 包装信息：25kg纸板桶/编织袋/塑料桶 价格：25.0元
联系方式：
联系人：张欢 电话：027-59308705 手机：18827031272

湖北鑫红利化工有限公司
产品介绍：
产品名称：二嗪磷 Cas号：333-41-5 纯度：99% 包装信息：1t吨袋,200kg镀锌铁桶/塑料桶,25kg纸板桶/编织袋/塑料桶,10kg铝听/纸箱,1kg铝箔袋/氟化瓶 价格：1.0元 - 1,000.0元
联系方式：
联系人：周女士 电话：027-59503710 手机：18871490254

上海吉至生化科技有限公司
产品介绍：
产品名称：二嗪磷标准溶液 Cas号：333-41-5 纯度：10μg/ml(u=6～4%,溶剂：丙酮） 包装信息：1mlea 价格：118.0元
联系方式：
联系人：江珊 电话：021-57520831 手机：15316869680

湖北广奥生物科技有限公司
产品介绍：
产品名称：二嗪磷 Cas号：333-41-5 纯度：99% 包装信息：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶,200kg镀锌铁桶/塑料桶,1t吨袋 价格：1.0元 - 1,000.0元
联系方式：
联系人：孙经理 电话：027-59223056 手机：15271829679

@2009-2024 洛克化工网 浙ICP备16009103号 版权声明