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- 1-甲基-3-(9H-硫杂蒽-9-甲基)哌啶盐酸盐美噻吨盐酸盐
1-甲基-3-(9H-硫杂蒽-9-甲基)哌啶盐酸盐美噻吨盐酸盐
1-甲基-3-(9H-硫杂蒽-9-甲基)哌啶盐酸盐美噻吨盐酸盐 基本信息
- 中文名称：
- 1-甲基-3-(9H-硫杂蒽-9-甲基)哌啶盐酸盐美噻吨盐酸盐
- 中文别名：
- 美噻吨盐酸盐;
1-甲基-3-(9H-硫杂蒽-9-甲基)哌啶盐酸盐美噻吨盐酸盐;
p-(dimethylamino)cinnamic acid;
(2E)-3-[4-(dimethylamino)phenyl]prop-2-enoic acid;
(2E)-3-[4-(dimethylamino)phenyl]prop-2-enoate;
4-(Dimethylamino)cinnamic acid;
3,3-bis(p-Dimethylaminophenyl)-6-dimethylaminophthalate;
6-(dimethylamino)-3,3-bis[4-(dimethylamino)phenyl]-1(3h)-isobenzofuranon;
6-(Dimethylamino)-3,3-bis[4-(dimethylamino)phenyl]phthalide;
Pergascript Blue I 2R;
6-(dimethylamino)-3,3-bis(4-(dimethylamino)phenyl)-1(3
- 英文名称：
- Piperidine,1-methyl-3-(9H-thioxanthen-9-ylmethyl)-, hydrochloride (1:1)
- 英文别名：
- Piperidine,1-methyl-3-(9H-thioxanthen-9-ylmethyl)-, hydrochloride (1:1);
methypranol;
Trimepranol;
metipranolol;
Turoptin;
1-Methyl-3-thioxanthen-9-ylmethyl-piperidin,Hydrochlorid;
Methixenhydrochlorid;
metipronalol;
Metixene hydrochloride;
OptiPranolol;
1-methyl-3-thioxanthen-9-ylmethyl-piperidine,hydrochloride;
Disorat;
Metipranololum;
methixene hydrochloride
- CAS No.：
- 1553-34-0
- 分 子 式：
- C20H23NS.ClH
- 分 子 量：
- 345.96
- 精确分子量：
- 345.13200
- PSA：
- 28.54000
- EINECS：
- 216-300-1
- InChI：
- InChI=1/C20H23NS.ClH.H2O/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20;;/h2-5,8-11,15,18H,6-7,12-14H2,1H3;1H;1H2
- 安全术语：
- Poison by ingestion, intraperitoneal, subcutaneous and intravenous routes. When heated to decomposition it emits very toxic fumes of NOx, SOx, and HCl.
- 分子结构式：
-
- SDS：
- 查看
1-甲基-3-(9H-硫杂蒽-9-甲基)哌啶盐酸盐美噻吨盐酸盐 物化性质
- 沸点：
- 419.7ºC at 760 mmHg
- 闪点：
- 207.6ºC
- 蒸汽压：
- 2.99E-07mmHg at 25°C
1-甲基-3-(9H-硫杂蒽-9-甲基)哌啶盐酸盐美噻吨盐酸盐 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TN1944000
- CHEMICAL NAME :
- Piperidine, 1-methyl-3-(thioxanthen-9-ylmethyl)-,
hydrochloride
- CAS REGISTRY NUMBER :
- 1553-34-0
- LAST UPDATED :
- 198812
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C20-H23-N-S.Cl-H
- MOLECULAR WEIGHT :
- 345.96
- WISWESSER LINE NOTATION :
- T C666 BS IHJ I1- CT6NTJ A1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1460 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 295 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1519 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 141,331,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 346 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 108 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 238 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 63,568,1964
1-甲基-3-(9H-硫杂蒽-9-甲基)哌啶盐酸盐美噻吨盐酸盐 下游产品
