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头孢唑肟钠
- 基本信息
- 制备方法及用途
- 物化性质
- 安全信息
- 毒理性
头孢唑肟钠 基本信息
- 中文名称：
- 头孢唑肟钠
- 中文别名：
- 头孢唑肟钠;
(6R,7R)-7-[[2,3-二氢-2-亚氨基-4-噻唑基)(甲氧亚氨基)乙酰基]氨基]-8-氧代-5-硫杂-1-氮杂二环[4.2.0]辛-2-烯-2-羧酸钠盐;
7-[(2-氨基-4-噻唑基)-2-甲氧亚胺基-乙酰氨基]-8-氧-5-硫杂-1-氮杂二环[4,2,0]-2-辛烯-2-羧酸单钠盐;
益保世灵
- 英文名称：
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-,sodium salt (1:1), (6R,7R)-
- 英文别名：
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-, sodium salt (1:1), (6R,7R)-;
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, monosodium salt, [6R-[6α,7β(Z)]]-;
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, monosodium salt, (6R,7R)- (9CI);
Cefizox;
Ceftix;
Ceftizon;
Ceftizoxime sodium;
Ceftizoxime sodium salt;
Eposerin;
FK 749;
FR 13479;
SKF 88373;
Sodium 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate
- CAS No.：
- 68401-82-1
- 分 子 式：
- C13H13N5O5S2.Na
- 分 子 量：
- 405.38
- 精确分子量：
- 406.02558
- PSA：
- 203.58000
- InChI：
- InChI=1/C13H13N5O5S2.Na/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18;/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22);/q;+1/p-1/b17-7-;/t8-,11-;/m1./s1
- 风险术语：
- 36/37/38
- 分子结构式：
-
- SDS：
- 查看
头孢唑肟钠 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XI0368000
- CHEMICAL NAME :
- 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic
acid, 7-(((2-amino-4-thiazolyl)-
(methoxyimino)acetyl)amino)-8-oxo-, monosodium salt,
(6R-(6-alpha,7-beta(Z)))-
- CAS REGISTRY NUMBER :
- 68401-82-1
- LAST UPDATED :
- 199306
- DATA ITEMS CITED :
- 18
- MOLECULAR FORMULA :
- C13-H12-N5-O5-S2.Na
- MOLECULAR WEIGHT :
- 405.41
- WISWESSER LINE NOTATION :
- T46 ANV ES GUTJ GVO CMVYUNO1&- ET5N CSJ BZ &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8130 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5570 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8930 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 24,905,1982
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >3200 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Cardiac - cardiomyopathy including infarction
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >3200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >3200 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 29120 mg/kg/13W-I
- TOXIC EFFECTS :
- Blood - hemorrhage
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 58240 mg/kg/26W-I
- TOXIC EFFECTS :
- Blood - hemorrhage
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 58240 mg/kg/26W-I
- TOXIC EFFECTS :
- Blood - hemorrhage
Skin and Appendages - dermatitis, other (after systemic exposure)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 8960 mg/kg/4W-I
- TOXIC EFFECTS :
- Blood - hemorrhage
Skin and Appendages - dermatitis, other (after systemic exposure)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphokinase
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 10 gm/kg
- SEX/DURATION :
- male 9 week(s) pre-mating
female 2 week(s) pre-mating - 22 day(s) after
conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 30,1669,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 27 gm/kg
- SEX/DURATION :
- male 9 week(s) pre-mating
female 2 week(s) pre-mating - 7 day(s) after
conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
- REFERENCE :
- JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968-
Volume(issue)/page/year: 34,466,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1100 mg/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968-
Volume(issue)/page/year: 34,466,1981
湖北帝柏化工有限公司
- 产品介绍：
-
产品名称：头孢唑肟钠
Cas号：68401-82-1
纯度：99%
包装信息：1kg,10kg,25kg,50kg,100kg
价格：14.0元 - 18.0元
- 联系方式：
-
联系人：雷经理
电话：15872383390
手机：15872383390
淄博航宇生物科技发展有限公司
- 产品介绍：
-
产品名称：头孢唑肟钠
Cas号：68401-82-1
纯度：99%
包装信息：100kg
价格：洽谈
- 联系方式：
-
联系人：张经理
电话：15666366704
手机：15666366704
沧州恩科医药科技有限公司
- 产品介绍：
-
产品名称：头孢唑肟钠
Cas号：68401-82-1
纯度：98%
包装信息：1kg,200kg
价格：888.0元 - 999.0元
- 联系方式：
-
联系人：赵经理
电话：0317-5106598
手机：13323075105
上海吉至生化科技有限公司
- 产品介绍：
-
产品名称：头孢唑肟钠
Cas号：68401-82-1
纯度：98%
包装信息：100mgea,50mgea
价格：598.0元 - 958.0元
- 联系方式：
-
联系人：Shirley张
电话：021-57520831
手机：18116052675
杭州鼎燕化工有限公司
- 产品介绍：
-
产品名称：头孢唑肟钠
Cas号：68401-82-1
纯度：99%
包装信息：1kg
价格：100.0元
- 联系方式：
-
联系人：Yuri
电话：0571-87157530
手机：18267553885
湖北恩星生物科技有限公司
- 产品介绍：
-
产品名称：头孢唑肟钠
Cas号：68401-82-1
纯度：
包装信息：100kg,200kg,300kg,400kg,500kg
价格：64.0元 - 100.0元
- 联系方式：
-
联系人：邵经理
电话：16621771607
手机：16621771607
苏州市森菲达化工有限公司
- 产品介绍：
-
产品名称：头孢唑肟钠
Cas号：68401-82-1
纯度：
包装信息：200kg
价格：洽谈
- 联系方式：
-
联系人：吴
电话：15195660023
手机：15195660023
湖北帝伯化工有限公司
- 产品介绍：
-
产品名称：头孢唑肟钠
Cas号：68401-82-1
纯度：99
包装信息：1
价格：1.0元
- 联系方式：
-
联系人：雷
电话：15872383390
手机：15872383390
湖北魏氏化学试剂股份有限公司
- 产品介绍：
-
产品名称：头孢唑肟钠
Cas号：68401-82-1
纯度：≥ 900u/mg
包装信息：1公斤/听kg
价格：洽谈
- 联系方式：
-
联系人：刘涛
电话：027-59101766
手机：13125137661
昆山嘉隆生物科技有限公司
- 产品介绍：
-
产品名称：头孢唑肟
Cas号：68401-82-1
纯度：99
包装信息：洽谈
价格：洽谈
- 联系方式：
-
联系人：孙涛
电话：18115683681
手机：18115683681
