伯氨喹

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 海关数据
  • 结构与计算化学
  • 上游产品
  • 下游产品

伯氨喹 基本信息

中文名称:
伯氨喹 
中文别名:
伯氨喹;
N-(6-甲氧基喹啉-8-基)戊-1,4-二胺;
伯喹 
英文名称:
1,4-Pentanediamine,N4-(6-methoxy-8-quinolinyl)-
英文别名:
primaquine;
N4-(6-methoxy-8-quinolinyl)1,4-pentanediamine;
Primaquinum;
N'-(6-methoxy-8-quinolinyl)-1,4-pentanediamine;
Primachin;
8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline;
4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine;
Primaquin;
PRIMAQUINE;
Neo-Quipenyl;
[14C]-Primaquine;
Primaquina;
Primachinum 
CAS No.:
90-34-6
分 子 式:

C15H21N3O

分 子 量:
259.35
精确分子量:
259.16800
PSA:
60.17000
EINECS:
201-987-2
InChI:
The Key: INDBQLZJXZLFIT-UHFFFAOYSA-N
危险品标志:

 

风险术语:

 

安全术语:

 

分子结构式:
SDS:
查看

伯氨喹 制备方法及用途

制备方法

对间日疟原虫红外期及各型疟原虫配子体有较强的杀虫作用,是根治间日疟疾与阻断各型疟疾传播的有效药物。伯氨喹对红内期裂殖体的作用弱,对噁性疟原虫的红内期裂殖体则无效,因此,不能用于控制症状。用于控制间日疟与三日疟的复发和传播以及防止噁性疟的传播。

用途简介

用途

对间日疟原虫红外期及各型疟原虫配子体有较强的杀虫作用,是根治间日疟疾与阻断各型疟疾传播的有效药物。伯氨喹对红内期裂殖体的作用弱,对噁性疟原虫的红内期裂殖体则无效,因此,不能用于控制症状。用于控制间日疟与三日疟的复发和传播以及防止噁性疟的传播。

伯氨喹 物化性质

沸点:
175-179ºC
其它信息:

1.性状:粘性液体。

2.沸点(℃):175-179(0.0266kPa)。

3.溶解性:溶于醚。

伯氨喹 安全信息

海关代码:
2933499090

伯氨喹 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA9650000
CHEMICAL NAME :
Quinoline, 8-(4-amino-1-methylbutylamino)-6-methoxy-
CAS REGISTRY NUMBER :
90-34-6
BEILSTEIN REFERENCE NO. :
0019337
LAST UPDATED :
199712
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C15-H21-N3-O
MOLECULAR WEIGHT :
259.39
WISWESSER LINE NOTATION :
T66 BNJ HO1 JMY1&3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
68800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
96 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
810 mg/kg/3W-I
TOXIC EFFECTS :
Behavioral - ataxia Liver - hepatitis (hepatocellular necrosis), zonal Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
283 mg/kg/5D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
336 mg/kg/16D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
8 mg/kg
REFERENCE :
SYXUD2 Shandong Yixueyuan Xuebao. Journal of Shandong Medical College. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 23,26,1985

伯氨喹 MSDS

  Material Safety Data Sheet

Section 1. Identification of the substance
    Product Name:      Primaquine    
    Synonyms:        N-(6-Methoxyquinolin-8-yl)pentane-1,4-diamine    

Section 2. Hazards identification
    Harmful by inhalation, in contact with skin, and if swallowed.

Section 3. Composition/information on ingredients.
    Ingredient name:        Primaquine    
    CAS number:        90-34-6    

Section 4. First aid measures
    Skin contact:        Immediately wash skin with copious amounts of water for at least 15 minutes while removing    
    contaminated clothing and shoes. If irritation persists, seek medical attention.
    Eye contact:        Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate    
    flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
    attention.
    Inhalation:        Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.    
    Ingestion:        Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.    

Section 5. Fire fighting measures
    In the event of a fire involving this material, alone or in combination with other materials, use dry
    powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
    should be worn.

Section 6. Accidental release measures
    Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
    standards.
    Respiratory precaution:        Wear approved mask/respirator    
    Hand precaution:        Wear suitable gloves/gauntlets    
    Skin protection:        Wear suitable protective clothing    
    Eye protection:        Wear suitable eye protection    
    Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
    for disposal. See section 12.
    Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
    Handling:        This product should be handled only by, or under the close supervision of, those properly qualified    
    in the handling and use of potentially hazardous chemicals, who should take into account the fire,
    health and chemical hazard data given on this sheet.
    Store in closed vessels.
    Storage:

Section 8. Exposure Controls / Personal protection
    Engineering Controls: Use only in a chemical fume hood.
    Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
    General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
    Appearance:        Not specified    
    Boiling point:        No data    
    No data
    Melting point:
    Flash point:        No data    
    Density:        No data    
    Molecular formula:        C15H21N3O    
    Molecular weight:        259.4    

Section 10. Stability and reactivity
    Conditions to avoid: Heat, flames and sparks.
    Materials to avoid: Oxidizing agents.
    Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

Section 11. Toxicological information
    No data.

Section 12. Ecological information
    No data.

Section 13. Disposal consideration
    Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
    disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
    Non-harzardous for air and ground transportation.

Section 15. Regulatory information
    No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
    302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
    Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

伯氨喹 海关数据

中国海关编码:2933499090

概述:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素:
品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
摘要/Summary:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

伯氨喹 分子结构与计算化学数据

分子结构数据

1、  摩尔折射率:75.86

2、  摩尔体积(cm3/mol):213.8

3、  等张比容(90.2K):566.5

4、  表面张力(dyne/cm):49.3

5、  极化率(10-24cm3):30.07

计算化学数据

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:2

3.氢键受体数量:4

4.可旋转化学键数量:6

5.互变异构体数量:无

6.拓扑分子极性表面积60.2

7.重原子数量:19

8.表面电荷:0

9.复杂度:262

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:1

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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