制霉菌素

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学

制霉菌素 基本信息

中文名称:
制霉菌素 
中文别名:
制霉菌素;
制霉素;
米可定,制霉素 
英文名称:
nystatin dihydrate
英文别名:
Nystatin;
Fungicidin Mycostatin;
nilstat;
Nystain;
biofanal;
nystatin A1;
nystatin A2;
nystan;
Nyotran;
Nystex;
stamycin;
MORONAL;
Nystop 
CAS No.:
1400-61-9
分 子 式:

C47H75NO17

分 子 量:
926.10
精确分子量:
925.50300
PSA:
327.45000
MDL:
MFCD00036240
EINECS:
215-749-0
InChI:
InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-10H,2,11-17H2,1H3,(H,19,20)
危险品标志:

 

风险术语:

 

安全术语:

S22;S24/25;

分子结构式:
SDS:
查看

制霉菌素 制备方法及用途

制备方法

主要用于内服治疗消化道真菌感染或外用于表面皮肤真菌感染。如牛的真菌性胃炎、鸡和火鸡哺囊真菌病等,对曲霉菌、毛霉菌引起的乳腺炎,乳管灌注也有效。对烟曲霉引起的雏鸡肺炎,喷雾吸入也有效。本品也用于长期服用广谱抗生素所致的真菌性二重感染。

用途简介

用途

菌谱及抗菌机理与两性霉素B相似,主要用于皮肤粘膜、口腔、阴道的白色念珠菌感染。

制霉菌素 物化性质

外观与性状:
黄色悬浮物
密度:
0.937g/cm3
沸点:
476ºC at 760mmHg
闪点:
127.3ºC
折射率:
1.503
蒸汽压:
1.6E-07mmHg at 25°C
存储条件/存储方法:

密封、在 -20ºC下保存

 

稳定性相关:

如果遵照规格使用和储存则不会分解,未有已知危险反应,避免氧化物

其它信息:

1.       性状:悬浮液

2.       密度(g/mL,25/4): 未确定

3.       相对蒸汽密度(g/mL,空气=1):未确定

4.       熔点(ºC):未确定

5.       沸点(ºC,常压):未确定

6.       沸点(ºC,5.2kPa): 未确定

7.       折射率: 未确定

8.       闪点(ºC): 未确定

9.       比旋光度(º): 未确定

10.    自燃点或引燃温度(ºC): 未确定

11.    蒸气压(kPa,25ºC): 未确定

12.    饱和蒸气压(kPa,60ºC): 未确定

13.    燃烧热(KJ/mol):未确定

14.    临界温度(ºC): 未确定

15.    临界压力(KPa): 未确定

16.    油水(辛醇/水)分配系数的对数值: 未确定

17.    爆炸上限(%,V/V):未确定

18.    爆炸下限(%,V/V): 未确定

19.    溶解性:不溶于水。

制霉菌素 安全信息

海关代码:
2942000000
危险类别码:
R11
安全说明:
S22-S24/25
安全标志:
S22:不要吸入粉尘。
S24/25:防止皮肤和眼睛接触。
危险标志:
F, C

制霉菌素 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RF5950000
CHEMICAL NAME :
Nystatin
CAS REGISTRY NUMBER :
1400-61-9
LAST UPDATED :
199512
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C46-H83-N-O18
MOLECULAR WEIGHT :
938.30
WISWESSER LINE NOTATION :
T-38-VO D&V GU IU MU OU QU SUTJ C1 D1 EQ F1 WQ A&VQ B&Q F&Q G&Q J&Q L&Q N&Q UO- BT6OTJ CQ DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
24305 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
180 mg/kg/90D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
100 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 33,306,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1053 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 8736 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1053 No. of Facilities: 372 (estimated) No. of Industries: 1 No. of Occupations: 10 No. of Employees: 25202 (estimated) No. of Female Employees: 22859 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9349 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2199 (estimated) No. of Female Employees: 2176 (estimated)
毒理学数据:

急性毒性:大鼠口经LD5010gm/kg;小鼠口经LD508gm/kg;大鼠腹经LD5024305ug/kg;小鼠腹经LD504400ug/kg;小鼠皮下LD50120mg/kg;小鼠静脉LD503mg/kg

生态数据:

对是水稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统,若无政府许可,勿将材料排入周围环境。

制霉菌素 MSDS


Section 1. Chemical Product and Company Identification
    Nystatin
    Common Name/
    Trade Name
    Nystatin

Section 3. Hazards Identification
    Potential Acute Health        Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.    
    Effects
    CARCINOGENIC EFFECTS: Not available.
    Potential Chronic Health
    MUTAGENIC EFFECTS: Not available.
    Effects
    TERATOGENIC EFFECTS: Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    Repeated or prolonged exposure is not known to aggravate medical condition.

Section 4. First Aid Measures
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water    
    for at least 15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention if
    irritation occurs.
    Skin Contact        Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation    
    develops.
    Serious Skin Contact        Not available.    
    Inhalation        If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.    
    Get medical attention.
    Serious Inhalation        Not available.    
    Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to
    Ingestion
    an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention
    if symptoms appear.
    Serious Ingestion        Not available.    

Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Flash Points        Not available.    
    Not available.
    Flammable Limits
    Not available.
    Products of Combustion
    Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
    Various Substances
    Explosion Hazards in        Risks of explosion of the product in presence of mechanical impact: Not available.    
    Presence of Various        Risks of explosion of the product in presence of static discharge: Not available.    
    Substances
    SMALL FIRE: Use DRY chemical powder.
    Fire Fighting Media
    LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
    and Instructions
    Material in powder form, capable of creating a dust explosion.
    Special Remarks on
    Fire Hazards
    Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential
    dust explosion hazard.
    Hazards
    Nystatin

Section 6. Accidental Release Measures
    Small Spill        Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by    
    spreading water on the contaminated surface and dispose of according to local and regional authority
    requirements.
    Large Spill        Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading    
    water on the contaminated surface and allow to evacuate through the sanitary system.

Section 7. Handling and Storage
    Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do
    Precautions
    not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or
    the label. Keep away from incompatibles such as oxidizing agents.
    Storage        Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 8°C    
    (46.4°F). Refrigerate. Moisture sensitive. Sensitive t o light. Store in light-resistant containers.

Section 8. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels    
    below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep
    exposure to airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.    
    Gloves.
    Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be
    a Large Spill        used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a    
    specialist BEFORE handling this product.
    Exposure Limits        Not available.    

Section 9. Physical and Chemical Properties
    Physical state and appearance Solid. (Powdered solid.)        Odor        Odor suggestive of cereal    
    Not available.
    Taste
    Not available.
    Molecular Weight
    Color        Tan. Yellow. (Light.)    
    pH (1% soln/water)        Not available.    
    Boiling Point        Not available.    
    Melting Point        Decomposition temperature: >160°C (320°F)    
    Not available.
    Critical Temperature
    Specific Gravity        Not available.    
    Not applicable.
    Vapor Pressure
    Vapor Density        Not available.    
    Volatility        Not available.    
    Odor Threshold        Not available.    
    Water/Oil Dist. Coeff.        The product is more soluble in oil; log(oil/water) = 7.1    
    Not available.
    Ionicity (in Water)
    Dispersion Properties        Not available.    
    Very slightly soluble in cold water.
    Solubility
    Insoluble in diethyl ether.
    Solubility in Water: 360 mg/l at 24 C.
    Nystatin

Section 10. Stability and Reactivity Data
    The product is stable.
    Stability
    Instability Temperature        Not available.    
    Excess heat, incompatible materials, light, moisture, dust generation.
    Conditions of Instability
    Incompatibility with various Reactive with oxidizing agents.
    substances
    Non-corrosive in presence of glass.
    Corrosivity
    Special Remarks on        Moisture sensitive Sensitive to light.    
    Reactivity        Heat, light and oxygen accelerate decomposition.    
    Special Remarks on        Not available.    
    Corrosivity
    Will not occur.
    Polymerization

Section 11. Toxicological Information
    Routes of Entry        Inhalation. Ingestion.    
    Toxicity to Animals        Acute oral toxicity (LD50): 8000 mg/kg [Mouse].    
    Chronic Effects on Humans Not available.
    Other Toxic Effects on        Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.    
    Humans
    Special Remarks on        Not available.    
    Toxicity to Animals
    Special Remarks on        May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data.    
    Chronic Effects on Humans May affect genetic material (mutagenic)
    Special Remarks on other        Acute Potential Health Effects:    
    Toxic Effects on Humans        Skin: May cause skin irritation.    
    Eyes: May cause eye irritation.
    Inhalation: May cause respiratory tract irritation.
    Ingestion: May cause gastrointestinal tract irritation with nausea, vomiting, diarrhea, and stomach pain.
    Chronic Potential Health Effects:
    Ingestion: Prolonged or repeated ingestion may cause weight loss. It may also affect behavior, blood
    (changes in serum composition), and urinary system (kidneys).
    Inhalation: Prolonged or repeated inhalation may cause allergic reaction.
    Skin: Prolonged or repeated skin contact may cause allergic contact dermatitis, although it is rare.

Section 12. Ecological Information
    Not available.
    Ecotoxicity
    Not available.
    BOD5 and COD
    Products of Biodegradation        Possibly hazardous short term degradation products are not likely. However, long term degradation    
    products may arise.
    Toxicity of the Products        The product itself and its products of degradation are not toxic.    
    of Biodegradation
    Special Remarks on the        Not available.    
    Products of Biodegradation
    Nystatin

Section 13. Disposal Considerations
    Waste Disposal        Waste must be disposed of in accordance with federal, state and local environmental    
    control regulations.

Section 14. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    Not applicable.
    Identification
    Not applicable.
    Special Provisions for
    Transport
    DOT (Pictograms)

Section 15. Other Regulatory Information and Pictograms
    No products were found.
    Federal and State
    Regulations
    California        California prop. 65: This product contains the following ingredients for which the State of California has    
    Proposition 65        found to cause cancer which would require a warning under the statute: No products were found.    
    Warnings
    California prop. 65: This product contains the following ingredients for which the State of California has
    found to cause birth defects which would require a warning under the statute: No products were found.
    EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS
    Other Regulations
    No. 215-749-0).
    Canada: Listed on Canadian Domestic Substance List (DSL).
    China: Not listed on National Inventory.
    Japan: Not listed on National Inventory (ENCS).
    Korea: Not listed on National Inventory (KECI).
    Philippines: Not listed on National Inventory (PICCS).
    Australia: Listed on AICS.
    WHMIS (Canada) Not controlled under WHMIS (Canada).
    Other Classifications
    This product is not classified        Not applicable.    
    DSCL (EEC)
    according to the EU regulations.
    Health Hazard
    HMIS (U.S.A.)        1 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    1 0 Reactivity
    Health
    Reactivity
    0
    Specific hazard
    Personal Protection
    E
    WHMIS (Canada)
    (Pictograms)
    DSCL (Europe)
    (Pictograms)
    Nystatin
    TDG (Canada)
    (Pictograms)
    ADR (Europe)
    (Pictograms)
    Protective Equipment
    Gloves.
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or
    equivalent.


SECTION 16 - ADDITIONAL INFORMATION
N/A

制霉菌素 分子结构与计算化学数据

分子结构数据

1、   摩尔折射率:240.33

2、   摩尔体积(m3/mol):696.1

3、   等张比容(90.2K):2018.5

4、   表面张力(dyne/cm):70.6

5、   极化率10-24cm3):95.27

计算化学数据

1、   疏水参数计算参考值(XlogP):-0.2

2、   氢键供体数量:12

3、   氢键受体数量:18

4、   可旋转化学键数量:3

5、   拓扑分子极性表面积(TPSA):320

6、   重原子数量:65

7、   表面电荷:0

8、   复杂度:1620

9、   同位素原子数量:0

10、   确定原子立构中心数量:10

11、   不确定原子立构中心数量:9

12、   确定化学键立构中心数量:6

13、   不确定化学键立构中心数量:0

14、   共价键单元数量:1

推荐供应商更多供应商>>

武汉市维斯尔曼生物工程有限公司

产品介绍:
产品名称:制霉菌素 Cas号:1400-61-9 纯度: 包装信息:洽谈 价格:洽谈
联系方式:
联系人:王明 电话:027-59402396 手机:13419635609

湖北云镁科技有限公司

产品介绍:
产品名称:制霉菌素 Cas号:1400-61-9 纯度:99% 包装信息:1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶 价格:1.0元 - 25.0元
联系方式:
联系人:方经理 电话:027-59206672 手机:18327059871

湖北诺纳科技有限公司

产品介绍:
产品名称:制霉菌素 Cas号:1400-61-9 纯度:99% 包装信息:1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶,1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶 价格:1.0元 - 25.0元
联系方式:
联系人:邵经理 电话:027-59209883 手机:17386169806

湖北津乐达化工有限公司

产品介绍:
产品名称:制霉菌素 Cas号:1400-61-9 纯度:98% 包装信息:1kg,25kg 价格:1.0元 - 1.0元
联系方式:
联系人:刘经理 电话:18086008865 手机:18086008865

湖北永阔科技有限公司

产品介绍:
产品名称:制霉菌素 Cas号:1400-61-9 纯度:99% 包装信息:25kg纸板桶/编织袋/塑料桶 价格:25.0元
联系方式:
联系人:陈娅楠 电话:027-59223108 手机:18064098002

天门恒昌化工有限公司

产品介绍:
产品名称:制霉菌素 Cas号:1400-61-9 纯度:99% 包装信息:25kg纸板桶/编织袋/塑料桶 价格:25.0元
联系方式:
联系人:向婷 电话:027-59322316 手机:18186660074

湖北实顺生物科技有限公司

产品介绍:
产品名称:制霉菌素 Cas号:1400-61-9 纯度:99% 包装信息:25kg纸板桶/编织袋/塑料桶 价格:25.0元
联系方式:
联系人:刘经理 电话:027-59223025 手机:15172526927

湖北齐飞医药化工有限公司

产品介绍:
产品名称:制霉菌素 Cas号:1400-61-9 纯度:99% 包装信息:25kg纸板桶/编织袋/塑料桶 价格:25.0元
联系方式:
联系人:王庆丽 电话:027-59322506 手机:18071128681

武汉鑫伟烨化工有限公司

产品介绍:
产品名称:制霉菌素 Cas号:1400-61-9 纯度:98% 包装信息:25kg,25kg,25kg 价格:1.0元 - 1.0元
联系方式:
联系人:郭经理 电话:027-85953558 手机:13377862267

湖北帝柏化工有限公司

产品介绍:
产品名称:制霉素 Cas号:1400-61-9 纯度:99% 包装信息:1kg,1kg,1kg,1kg,1kg 价格:18.0元 - 18.0元
联系方式:
联系人:雷经理 电话:15872383390 手机:15872383390