2-[N-甲基-N-(2-吡啶基)氨基]乙醇

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 海关数据
  • 结构与计算化学
  • 上游产品
  • 下游产品

2-[N-甲基-N-(2-吡啶基)氨基]乙醇 基本信息

中文名称:
2-[N-甲基-N-(2-吡啶基)氨基]乙醇 
中文别名:
2-[N-甲基-N-(2-吡啶基)氨基]乙醇;
N-甲基-2-(哌啶-4-基氧)氨基乙醇;
2-(N-甲基-2-吡啶氨基)乙醇;
N-甲基-N-(2-吡啶基)氨基乙醇 
英文名称:
Ethanol,2-(methyl-2-pyridinylamino)-
英文别名:
2-N-Methyl-2-pyridylaminoethanol;
2-(N-Methyl-2-pyridylaMino)ethanol;
2-(Methyl(pyridin-2-yl)amino)ethanol;
2-[N-(2-Hydroxyethyl)-N-methylamino]pyridine;
intermediate of Rsiglitazone;
2-(Methyl-2-pyridylamino)ethanol;
IFLAB-BB F2108-0001;
N-Methyl-N-(2-pyridyl)ethanolamine 
CAS No.:
122321-04-4
分 子 式:
C8H12N2O
分 子 量:
152.19
精确分子量:
152.09500
PSA:
36.36000
MDL:
MFCD02667633
InChI:
InChI=1/C8H12N2O/c1-10(6-7-11)8-4-2-3-5-9-8/h2-5,11H,6-7H2,1H3
危险品标志:
HarmfulXn
风险术语:
R22;R36/37/38
安全术语:
S26;S37/39
分子结构式:
SDS:
查看

2-[N-甲基-N-(2-吡啶基)氨基]乙醇 制备方法及用途

制备方法

1、用作药物罗格列酮中间体

用途简介

用途

1、   用作药物罗格列酮中间体

2-[N-甲基-N-(2-吡啶基)氨基]乙醇 物化性质

外观与性状:
透明淡黄色至淡棕色粘性液体
密度:
1.13g/cm3
沸点:
98-100°C 0,1mm
闪点:
123.9ºC
折射率:
1.5705-1.5735
蒸汽压:
0.00172mmHg at 25°C
存储条件/存储方法:

保持贮藏器密封、储存在阴凉、干燥的地方,确保工作间有良好的通风或排气装置

稳定性相关:

如果遵照规格使用和储存则不会分解,未有已知危险反应

避免氧化物
其它信息:

1.        性状:棕色粘性液体

2.         密度(g/mL,20):未确定

3.         相对蒸汽密度(g/mL,空气=1):未确定

4.         熔点(ºC):未确定

5.         沸点(ºC,常压):未确定

6.         沸点(ºC,0.01KPa):98-100

7.         折射率:n20/D 1.5705-1.5735

8.         闪点(ºC):未确定

9.         比旋光度(º):未确定

10.      自燃点或引燃温度(ºC):未确定

11.      蒸气压(Pa,20ºC):未确定

12.      饱和蒸气压(KPa,20ºC):未确定

13.      燃烧热(KJ/mol):未确定

14.      临界温度(ºC):未确定

15.      临界压力(KPa):未确定

16.      油水(辛醇/水)分配系数的对数值:未确定

17.      爆炸上限(%,V/V):未确定

18.      爆炸下限(%,V/V):未确定

19.     溶解性:未确定

 

2-[N-甲基-N-(2-吡啶基)氨基]乙醇 安全信息

海关代码:
2933399090
危险类别码:
R22;R36/37/38
安全说明:
S37/39-S26
危险标志:
Xn:Harmful;

2-[N-甲基-N-(2-吡啶基)氨基]乙醇 毒理性

生态数据:

通常对水是稍微有危害的,若无政府许可,勿将材料排入周围环境。

2-[N-甲基-N-(2-吡啶基)氨基]乙醇 MSDS

Name: 2-N-methyl-2-pyridylaminoethanol Material Safety Data Sheet
Synonym:
CAS: 122321-04-4
Section 1 - Chemical Product   MSDS Name:2-N-methyl-2-pyridylaminoethanol Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
122321-04-4 2-N-Methyl-2-pyridylaminoethanol unlisted
Hazard Symbols: XN
Risk Phrases: 22 36/37/38

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Harmful if swallowed. Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.

Section 7 - HANDLING and STORAGE
  Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 122321-04-4: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Liquid
Color: faint yellow - light yellow to light brown
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C8H12N2O
Molecular Weight: 152.2

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 122321-04-4 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-N-Methyl-2-pyridylaminoethanol - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 122321-04-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 122321-04-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 122321-04-4 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

2-[N-甲基-N-(2-吡啶基)氨基]乙醇 海关数据

中国海关编码:2933399090

概述:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素:
品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
摘要/Summary:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-[N-甲基-N-(2-吡啶基)氨基]乙醇 分子结构与计算化学数据

分子结构数据

1、摩尔折射率:44.82

2、摩尔体积(cm3/mol):134.6

3、等张比容(90.2K):359.9

4、表面张力(dyne/cm):51

5、介电常数:无可用的

6、极化率(10-24cm3):17.77

7、单一同位素质量:152.094963 Da

8、标称质量:152 Da

9、平均质量:152.1937 Da

计算化学数据

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:1

3.氢键受体数量:3

4.可旋转化学键数量:3

5.互变异构体数量:无

6.拓扑分子极性表面积36.4

7.重原子数量:11

8.表面电荷:0

9.复杂度:108

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

2-[N-甲基-N-(2-吡啶基)氨基]乙醇 上游产品

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