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嘌嘧替派 基本信息
- 中文名称：
- 嘌嘧替派
- 中文别名：
- 嘌嘧替派
- 英文名称：
- Phosphinic amide,P,P-bis(1-aziridinyl)-N-[2-(dimethylamino)-7-methyl-7H-purin-6-yl]-
- 英文别名：
- Pumitepa;
<32P>-Fopunic;
6-Diethylenimidophosphoamido-2-dimethylamino-7-methylpurin;
bis-aziridin-1-yl-phosphinic acid 2-dimethylamino-7-methyl-7H-purin-6-ylamide;
Bis(1-aziridinyl)[[2-(dimethylamino)-7-methyl-7H-purin-6-yl]amino]phosphine oxide
- CAS No.：
- 42061-52-9
- 分 子 式：
- C12H19N8OP
- 分 子 量：
- 0
- 精确分子量：
- 322.14200
- PSA：
- 91.77000
- InChI：
- The Key: KAEVHZSIYLATMK-UHFFFAOYSA-N
- 分子结构式：
-
- SDS：
- 查看
嘌嘧替派 物化性质
- 密度：
- 1.7g/cm3
- 沸点：
- 528.7ºC at 760mmHg
- 闪点：
- 273.5ºC
- 折射率：
- 1.828
嘌嘧替派 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SZ5827000
- CHEMICAL NAME :
- Phosphinic amide,
P,P-bis(1-aziridinyl)-N-(2-(dimethylamino)-7-methyl-7
H-purin-6-yl)-
- CAS REGISTRY NUMBER :
- 42061-52-9
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C12-H19-N8-O-P
- MOLECULAR WEIGHT :
- 322.36
- WISWESSER LINE NOTATION :
- T56 BN DN FN HNJ B1 GN1&1 IMPO&- AT3NTJ&- AT3NTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 175 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 24 mg/kg
- REFERENCE :
- BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of
Experimental Biology and Medicine. For English translation, see BEXBAN.
(V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 102(7),76,1986
