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- 4-[(亚硝基甲基)氨基]-2-丁酮
4-[(亚硝基甲基)氨基]-2-丁酮 基本信息
- 中文名称：
- 4-[(亚硝基甲基)氨基]-2-丁酮
- 中文别名：
- 4-[(Nitrosomethyl)amino]-2-butanone
- 英文名称：
- 2-Butanone,4-[(nitrosomethyl)amino]-
- 英文别名：
- 4-[(Nitrosomethyl)amino]-2-butanone;
2-Butanone,4-[(nitrosomethyl)amino]-
- CAS No.：
- 89367-15-7
- 分 子 式：
- C5H10N2O2
- 分 子 量：
- 130.17
- 精确分子量：
- 130.07400
- PSA：
- 58.53000
- 安全术语：
- Moderately toxic by subcutaneous route. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also NITROSAMINES.
- 分子结构式：
-
- SDS：
- 查看
4-[(亚硝基甲基)氨基]-2-丁酮 物化性质
- 密度：
- 1.12g/cm3
- 沸点：
- 196.7ºC at 760 mmHg
- 闪点：
- 72.7ºC
- 折射率：
- 1.484
4-[(亚硝基甲基)氨基]-2-丁酮 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EL9154000
- CHEMICAL NAME :
- 2-Butanone, 4-(methylnitrosamino)-
- CAS REGISTRY NUMBER :
- 89367-15-7
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C5-H10-N2-O2
- MOLECULAR WEIGHT :
- 130.17
- WISWESSER LINE NOTATION :
- ONN1&2V1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 705 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Liver - other changes
Kidney, Ureter, Bladder - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 770 mg/kg/38W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Gastrointestinal - colon tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 1377 mg/kg/34W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Gastrointestinal - tumors
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 700 umol/L
- REFERENCE :
- 50EYAN "Structure-Activity Correlation as a Predictive Tool in Toxicology,
Papers from a Symposium, 1981," Golberg, L., ed., Washington, DC, Hemisphere
Pub. Corp., 1983 Volume(issue)/page/year: -,241,1983
