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- 1-(4-氟苯基)-4-(4-苯基哌嗪-1-基)丁烷-1-酮
1-(4-氟苯基)-4-(4-苯基哌嗪-1-基)丁烷-1-酮
1-(4-氟苯基)-4-(4-苯基哌嗪-1-基)丁烷-1-酮 基本信息
- 中文名称：
- 1-(4-氟苯基)-4-(4-苯基哌嗪-1-基)丁烷-1-酮
- 中文别名：
- 1-(4-fluorophenyl)-4-(4-phenylpiperazin-1-yl)butan-1-one
- 英文名称：
- 1-Butanone,1-(4-fluorophenyl)-4-(4-phenyl-1-piperazinyl)-
- 英文别名：
- 1-(4-fluorophenyl)-4-(4-phenylpiperazin-1-yl)butan-1-one;
Butyropipazone;
Butropipazone;
R 1892;
Galvanisone;
Butropipazon
- CAS No.：
- 2354-61-2
- 分 子 式：
- C20H23FN2O
- 分 子 量：
- 326.45
- 精确分子量：
- 326.17900
- PSA：
- 23.55000
- InChI：
- The Key: QPHRVUMZLUQZGU-UHFFFAOYSA-N
- 安全术语：
- Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of F− and NOx.
- 分子结构式：
-
- SDS：
- 查看
1-(4-氟苯基)-4-(4-苯基哌嗪-1-基)丁烷-1-酮 物化性质
- 密度：
- 1.137g/cm3
- 沸点：
- 481.2ºC at 760mmHg
- 闪点：
- 244.8ºC
- 折射率：
- 1.565
- 蒸汽压：
- 2.03E-09mmHg at 25°C
1-(4-氟苯基)-4-(4-苯基哌嗪-1-基)丁烷-1-酮 安全信息
1-(4-氟苯基)-4-(4-苯基哌嗪-1-基)丁烷-1-酮 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EU4200000
- CHEMICAL NAME :
- Butyrophenone, 4'-fluoro-4-(4-phenyl-1-piperazinyl)-
- CAS REGISTRY NUMBER :
- 2354-61-2
- BEILSTEIN REFERENCE NO. :
- 0895232
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C20-H23-F-N2-O
- MOLECULAR WEIGHT :
- 326.45
- WISWESSER LINE NOTATION :
- T6NTJ A1OR DF& DR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 550 mg/kg
- TOXIC EFFECTS :
- Behavioral - toxic psychosis
- REFERENCE :
- PHMGBN Pharmacology: International Journal of Experimental and Clinical
Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1-
1968- Volume(issue)/page/year: 15,485,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 550 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis
Autonomic Nervous System - central sympatholytic
Behavioral - alteration of classical conditioning
- REFERENCE :
- MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc.,
1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year:
4(2),199,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,186,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 650 mg/kg
- TOXIC EFFECTS :
- Behavioral - toxic psychosis
- REFERENCE :
- PHMGBN Pharmacology: International Journal of Experimental and Clinical
Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1-
1968- Volume(issue)/page/year: 15,485,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 76 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,186,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3,
1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year:
2,17,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,186,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960-
Volume(issue)/page/year: 3,432,1962
1-(4-氟苯基)-4-(4-苯基哌嗪-1-基)丁烷-1-酮 海关数据
中国海关编码：2933599090
- 概述：
- 2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- 摘要/Summary：
- 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
