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N,N'-二甲基亚硝基脲 基本信息
- 中文名称：
- N,N'-二甲基亚硝基脲
- 中文别名：
- N,N'-二甲基亚硝基脲
- 英文名称：
- Urea,N,N'-dimethyl-N'-nitroso-
- 英文别名：
- 1,3-dimethyl-1-nitrosourea;
N,N'-Dimethylnitrosourea;
1,3 dimethyl 1 nitrosourea;
N-nitroso-1,3-dimethylurea;
Dimethylnitrosourea;
1,3-Dimethylnitrosourea;
N-nitroso-N,N'-dimethylurea;
1,3-Dimethyl-N-nitrosourea;
1,2-Dimethyl-1-nitrosourea;
Nitrosodimethylurea;
N,N'-Dimethyl-N-nitrosourea;
N-Nitrosodimethylurea
- CAS No.：
- 13256-32-1
- 分 子 式：
- C3H7N3O2
- 分 子 量：
- 117.13
- 精确分子量：
- 117.05400
- PSA：
- 61.77000
- InChI：
- The Key: BHMHNSQLZKUIMD-UHFFFAOYSA-N
- 安全术语：
- Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.
- 分子结构式：
-
- SDS：
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N,N'-二甲基亚硝基脲 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YT0350000
- CHEMICAL NAME :
- Urea, 1,3-dimethyl-1-nitroso-
- CAS REGISTRY NUMBER :
- 13256-32-1
- BEILSTEIN REFERENCE NO. :
- 1756842
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 22
- MOLECULAR FORMULA :
- C3-H7-N3-O2
- MOLECULAR WEIGHT :
- 117.13
- WISWESSER LINE NOTATION :
- ONN1&VM1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1300 mg/kg/65W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
Peripheral Nerve and Sensation - peripheral nerve tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 836 mg/kg/20W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Brain and Coverings - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 660 mg/kg/66W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
Peripheral Nerve and Sensation - peripheral nerve tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 720 mg/kg/9W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 680 mg/kg/17W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Skin and Appendages - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 56222 mg/kg/30W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 20 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 10 mg/kg
- SEX/DURATION :
- female 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 50 mg/kg
- SEX/DURATION :
- female 9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- DNA inhibition
MUTATION DATA
- TYPE OF TEST :
- Host-mediated assay
- TEST SYSTEM :
- Rodent - mouse Ascites tumor
- DOSE/DURATION :
- 100 mg/kg
- REFERENCE :
- EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 8(3),70,1986
