葡萄糖酸钙

外观与性状：

白色结晶粉末或颗粒

熔点：

195°C

沸点：

673.6ºC at 760 mmHg

闪点：

375.2ºC

水溶解性：

3.3 g/100mL

存储条件/存储方法：

库房低温通风干燥

稳定性相关：

它能降低毛细血管渗透性，增加致密度，维持神经和肌肉的正常兴奋性，加强心肌收缩力，并有助于骨质形成。它的抗过敏作用是由于钙离子能增加毛细血管的致密度、降低其渗透性，减少渗出，从而减轻或缓解过敏症状。

其它信息：

性状：本品为白色结晶性或颗粒性粉末，无臭，无味。

密度（g/mL,25/4℃）： 不可用

海关代码：

2918160000

WGK_Germany：

1
德国有关水污染物质的分类清单

危险类别码：

20/21/22-36/37/38

安全说明：

S24/25

RTECS号：

EW2100000

危险标志：

Xn

CHEMICAL IDENTIFICATION

RTECS NUMBER :

EW2100000

CHEMICAL NAME :

Calcium gluconate

CAS REGISTRY NUMBER :

299-28-5

LAST UPDATED :

199701

DATA ITEMS CITED :

13

MOLECULAR FORMULA :

C12-H22-O14.Ca

MOLECULAR WEIGHT :

430.42

WISWESSER LINE NOTATION :

QVYQYQYQYQ1Q 2 &-CA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

SPECIES OBSERVED :

Human - infant

DOSE/DURATION :

143 mg/kg

TOXIC EFFECTS :

Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase

REFERENCE :

JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 129,347,1945

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intramuscular

SPECIES OBSERVED :

Human - infant

DOSE/DURATION :

10 gm/kg

TOXIC EFFECTS :

Brain and Coverings - meningeal changes Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Nutritional and Gross Metabolic - body temperature increase

REFERENCE :

JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 129,347,1945

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

10 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 26,144,1971

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

950 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,226,1982

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

10 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 26,144,1971

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 15(1-2),121,1984

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2890 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 45,47,1956

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

950 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,492,1962

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

1987 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 47,183,1933

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

1810 mg/kg

TOXIC EFFECTS :

Cardiac - other changes Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 191,44,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80373 No. of Facilities: 267 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 14905 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80373 No. of Facilities: 565 (estimated) No. of Industries: 3 No. of Occupations: 16 No. of Employees: 29060 (estimated) No. of Female Employees: 23111 (estimated)

毒理学数据：

 

 

生态数据：

其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。

中国海关编码：2918160000

概述：

2918160000. 葡糖酸及其盐和酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

申报要素：

品名, 成分含量, 用途

摘要/Summary：

2918160000. gluconic acid, its salts and esters. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:10

3.氢键受体数量:14

4.可旋转化学键数量:8

5.互变异构体数量:无

6.拓扑分子极性表面积283

7.重原子数量:27

8.表面电荷:0

9.复杂度:165

10.同位素原子数量:0

11.确定原子立构中心数量:8

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:3

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  葡糖酸钙红外图谱(IR1)
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  葡糖酸钙红外图谱(IR2)