毒死蜱

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 海关数据
  • 结构与计算化学
  • 上游产品
  • 下游产品
  • 表征图谱

毒死蜱 基本信息

中文名称:
毒死蜱 
中文别名:
毒死蜱;
氯蜱硫磷;
O,O-二乙基-O-(3,5,6-三氯-2-吡啶基)硫代磷酸;
O,O-二乙基-O-(3,5,6-三氯-2-吡啶基)硫逐磷酸酯;
乐斯本 
英文名称:
Chlorpyrifos
英文别名:
chlorpyrifos;
Clorpyrifos;
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate;
Empire;
Chlorpyrifos,Chlorpyriphos;
Brodan;
O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioate;
chloropyrifos;
chlopyrifos;
DOWCO;
Eradex;
CUGAT;
Pyrine;
Zidil;
suSCon;
O,O-diethyl O-(3,5,6-trichloropyridin-2-yl) phosphorothioate;
0,0-Diethyl-O-[3,5,6-trichloro-2-pyridyl]phosphorothioate;
O,O-Diethyl O-3,5,6-Trichloro-2-Pyridyl Phosphorothioate;
Equity;
DURSBAN;
chlorpyriphos-ethyl;
Chlorpyriphos;
Chlorpyrifos 
CAS No.:
2921-88-2
分 子 式:

C9H11Cl3NO3PS

分 子 量:
350.58
精确分子量:
348.92600
PSA:
82.48000
MDL:
MFCD00041800
EINECS:
220-864-4
InChI:
InChI=1/C9H11Cl3NO3PS/c1-3-15-17(14,16-4-2)18-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3
危险品标志:

toxictharmfulxnirritantxidangerousn

风险术语:

R25;R50/53;R36;R20/21/22;R11;R38

安全术语:

S1/2;S45;S60;S61;S36/37;S26

分子结构式:
SDS:
查看

毒死蜱 制备方法及用途

制备方法

1.由二乙基硫代磷酰氯与3,5,6-三氯-2-吡啶醇反应制得。 2.将吡啶在催化剂存在下,氯化制得五氯吡啶。然后以乙腈为溶剂,在一定温度下缓慢滴加锌粉/氯化铵水溶液,反应得2,3,5,6-四氯吡啶,经碱解,得到2-羟基-3,5,6-三氯吡啶。该化合物与O,O'-二乙基硫代磷酰氯反应,经处理即得毒死蜱。

合成制备方法

1.由二乙基硫代磷酰氯与3,5,6-三氯-2-吡啶醇反应制得。

2.将吡啶在催化剂存在下,氯化制得五氯吡啶。然后以乙腈为溶剂,在一定温度下缓慢滴加锌粉/氯化铵水溶液,反应得2,3,5,6-四氯吡啶,经碱解,得到2-羟基-3,5,6-三氯吡啶。该化合物与O,O'-二乙基硫代磷酰氯反应,经处理即得毒死蜱。

用途简介

是硫代磷酸酯类杀虫剂,具有触杀、胃毒和熏蒸作用。在叶片上的残留期不长,但在土壤中的残留期则较长,因此对地下害虫的防治效果较好。在推荐剂量下,对多数作物没有药害,但对烟草敏感。

用途

1.为广谱杀虫、杀螨剂,在土地中挥发性较高。适用于防治柑桔、棉花、玉米、苹果、梨、水稻、花生、大豆、小麦及茶树等多种作物上的害虫和螨类。

2.非内吸性的广谱杀虫剂,具有接触、胃毒和熏蒸作用。用于玉米、棉花、大豆、花生、甜菜、果树、蔬菜等作物。防治蚊蝇、蟑螂、白蚁等家庭害虫、粮仓害虫和家畜体外寄生虫。一般加工成乳油或颗粒剂。可与非碱性农药混用。

3.高效、广谱、低残留有机磷杀虫剂,具有触杀、胃毒和熏蒸作用,无内吸作用。可防治茶尺蠖、小绿叶蝉、茶橙瘿螨、棉蚜、棉红蜘蛛、稻飞虱、稻纵卷叶螟、蚊、蝇、小麦黏虫以及牛、羊体外寄生虫和地下害虫。

毒死蜱 物化性质

外观与性状:
白色粒状的晶体
密度:
1.398
熔点:
42-44°C
沸点:
200°C
闪点:
2 °C
水溶解性:
Insoluble. 0.00013 g/100 mL
折射率:
1.56
蒸汽压:
4.09E-06mmHg at 25°C
存储条件/存储方法:
库房通风低温干燥,与食品原料分开储运
稳定性相关:

在酸性介质中稳定,在碱性介质中易分解

其它信息:

1.      性状:白色结晶,具有轻微的硫醇味

2.      密度(g/mL,25/4℃):1.398

3.      相对蒸汽密度(g/mL,空气=1):无可用

4.      熔点(ºC):42.5-43

5.      沸点(ºC,常压):200

6.      沸点(ºC,5.2kPa):无可用

7.      折射率:无可用

8.      闪点(ºC):2

9.      比旋光度(º):无可用

10.   自燃点或引燃温度(ºC):无可用

11.   蒸气压(kPa,25ºC):无可用

12.   饱和蒸气压(kPa,60ºC):无可用

13.   燃烧热(KJ/mol):无可用

14.   临界温度(ºC):无可用

15.   临界压力(KPa):无可用

16.   油水(辛醇/水)分配系数的对数值:无可用

17.   爆炸上限(%,V/V):无可用

18.   爆炸下限(%,V/V):无可用

19.   溶解性:微溶于水,溶于大部分有机溶剂

毒死蜱 安全信息

包装等级:
III
风险类别:
6.1(b)
海关代码:
2933399021
危险类别码:
R25;R50/53
安全说明:
S1/2-S45-S60-S61-S36/37-S26
RTECS号:
TF6300000
安全标志:
S60:本物质残余物和容器必须作为危险废物处理。
S61:避免排放到环境中。参考专门的说明/安全数据表。
危险标志:
T;N

毒死蜱 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TF6300000
CHEMICAL NAME :
Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) ester
CAS REGISTRY NUMBER :
2921-88-2
LAST UPDATED :
199806
DATA ITEMS CITED :
64
MOLECULAR FORMULA :
C9-H11-Cl3-N-O3-P-S
MOLECULAR WEIGHT :
350.59
WISWESSER LINE NOTATION :
T6NJ BOPS&O2&O2 CG EG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis Behavioral - muscle weakness Behavioral - coma
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
82 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>200 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
202 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
192 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
504 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - pigeon
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
25400 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
13300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
76 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
163 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
730 mg/kg/2Y-C
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
21840 ug/kg/28D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg/8W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - somnolence (general depressed activity) Behavioral - tremor
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
2190 mg/kg/2Y-C
TOXIC EFFECTS :
Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
980 mg/kg/2W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
210 ug/kg
SEX/DURATION :
female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
4500 ug/kg
SEX/DURATION :
female 7-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
200 mL/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
50 mg/kg
SEX/DURATION :
female 12-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - other effects to embryo
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
200 mg/kg
SEX/DURATION :
female 12-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - mouse Cells - not otherwise specified
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,165,1992 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.2 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 50,1,1974 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.2 mg/m3;STEL 0.6 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.2 mg/m3;STEL 0.6 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.2 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 0.2 mg/m3;STEL 0.6 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 0.2 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.2 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 mg/m3;STEL 0.6 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHLORPYRIFOS-air:10H TWA 0.2 mg/m3;STEL 0.6 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4463 No. of Facilities: 753 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 22523 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0714 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 7 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4463 No. of Facilities: 1276 (estimated) No. of Industries: 4 No. of Occupations: 3 No. of Employees: 11404 (estimated) No. of Female Employees: 842 (estimated)
毒理学数据:

1。
试验方法:口服
摄入剂量:300毫克/千克
测试对象:人-人
毒性类型:急性
毒性作用:1.神经和感觉异常
2.肌肉无力
3.昏迷

2。
试验方法:口服
摄入剂量:82毫克/千克
测试对象:啮齿动物-鼠
毒性类型:急性
毒性作用:详细的毒副作用没有报告以外的其他致死剂量值

3。
试验方法:吸入
摄入剂量:“200mg/m3/4H
测试对象:啮齿动物-鼠
毒性类型:急性
毒性作用:详细的毒副作用没有报告以外的其他致死剂量值

 

生态数据:

该物质对环境可能有危害,对水体应给予特别注意。

毒死蜱 MSDS

毒死蜱 海关数据

中国海关编码:2933399021

概述:
2933399021 精吡氟禾草灵,毒死蜱,二氯氨基吡啶羧酸〔包括二氟吡隆,啶虫丙醚,氯虫苯甲酰胺〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%
申报要素:
品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
监管条件:
S.进出口农药登记证明
摘要/Summary:
2933399021 (r)-2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenoxy)propanoic acid。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

毒死蜱 分子结构与计算化学数据

分子结构数据

1、  摩尔折射率:77.23

2、  摩尔体积(cm3/mol):236.7

3、  等张比容(90.2K):637.9

4、  表面张力(dyne/cm):52.7

5、  极化率(10-24cm3):30.61

计算化学数据

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:0

3.氢键受体数量:5

4.可旋转化学键数量:6

5.互变异构体数量:无

6.拓扑分子极性表面积72.7

7.重原子数量:18

8.表面电荷:0

9.复杂度:303

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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