葡萄糖酸氯己定 [18472-51-0]

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学

葡萄糖酸氯己定 [18472-51-0] 基本信息

中文名称:
葡萄糖酸氯己定 [18472-51-0] 
中文别名:
葡萄糖酸氯己定;
氯己定二葡糖酸盐;
伞花醇;
二葡糖酸氯己定;
1,1'-六亚甲基双[5-(4-氯苯基)双胍]二葡糖酸盐;
1,6-双(N1-对氯苯基-N5-双胍基)己烷二葡萄糖酸盐 
英文名称:
Chlorhexidine digluconate
英文别名:
chlorhexidine gluconate;
corsodyl;
Chlorhexidine digluconate;
chlorhexidine gigluconate;
placout;
septeal;
abacil;
chlorohexidine digluconate;
hibidil;
1,1'-Hexamethylenebis(5-[p-chlorophenyl]biguanide);
1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] Digluconate;
disteryl;
1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane;
Chlorhexidin Bigluconate;
Chlorhexamed;
orahexal;
1,1‘-Hexamethylenebis(5-[p-chlorophenyl]biguanide);
unisept 
CAS No.:
18472-51-0
分 子 式:
C34H54Cl2N10O14
分 子 量:
897.56
精确分子量:
896.32000
PSA:
444.48000
MDL:
MFCD00083599
EINECS:
242-354-0
InChI:
InChI=1/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)
分子结构式:
SDS:
查看

葡萄糖酸氯己定 [18472-51-0] 制备方法及用途

制备方法

消毒防腐药,葡萄糖酸氯己定具有相当强的广谱抑菌、杀菌作用,对革兰氏阳性菌及革兰氏阴性菌均有效。外用手、皮肤消毒,冲洗创口。

用途简介

用途

消毒防腐药。

葡萄糖酸氯己定 [18472-51-0] 物化性质

外观与性状:
无色至淡黄色透明液体
密度:
1.06 g/mL at 25 °C(lit.)
熔点:
134ºC
沸点:
699.3ºC at 760 mmHg
闪点:
376.7ºC
蒸汽压:
0mmHg at 25°C
存储条件/存储方法:
库房低温通风干燥
稳定性相关:

常温常压下稳定

避免的物料:  水溶液与碱金属碱土金属和许多有机无机的活性化学药品是不相溶的

其它信息:

1.       性状:外观无色或淡黄色几乎透明略为黏稠的液体;无臭或几乎无臭

2.       密度(g/mL,25/4):1.06(lit.)

3.       相对蒸汽密度(g/mL,空气=1):不确定

4.       熔点(ºC):不确定

5.       沸点ºC,常压):不确定

6.       沸点(ºC, 5.2kPa):不确定

7.       折射率:不确定

8.       闪点(ºC):不确定

9.       比旋光度(º):不确定

10.    自燃点或引燃温度(ºC):不确定

11.    蒸气压(kPa,25ºC):不确定

12.    饱和蒸气压(kPa,60ºC):不确定

13.    燃烧热(KJ/mol):不确定

14.    临界温度(ºC):不确定

15.    临界压力(KPa):不确定

16.    油水(辛醇/水)分配系数的对数值:不确定

17.    爆炸上限(%,V/V):不确定

18.    爆炸下限(%,V/V):不确定

19.    溶解性:不确定

葡萄糖酸氯己定 [18472-51-0] 安全信息

海关代码:
3004909090
WGK_Germany:
-
德国有关水污染物质的分类清单

葡萄糖酸氯己定 [18472-51-0] 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DU1950000
CAS REGISTRY NUMBER :
18472-51-0
LAST UPDATED :
199706
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C22-H30-Cl2-N10.2C6-H12-O7
MOLECULAR WEIGHT :
897.88
WISWESSER LINE NOTATION :
GR DMYUM&MYUM&M6MYUM&MYUM&MR DG &QVYQYQYQYQ1Q 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
24200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA repair
TEST SYSTEM :
Bacteria - Bacillus subtilis
DOSE/DURATION :
1 mg/L
REFERENCE :
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953- Volume(issue)/page/year: 32,171,1986 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3093 No. of Facilities: 4592 (estimated) No. of Industries: 5 No. of Occupations: 36 No. of Employees: 643404 (estimated) No. of Female Employees: 561783 (estimated)
毒理学数据:

急性毒性:大鼠口经LD502 mg/kg大鼠皮下注射LD50 3320 mg/kg大鼠静脉LD50 24200 ug/kg小鼠口经LD50 1260 mg/kg小鼠皮下注射LD50 1140 mg/kg小鼠静脉LD50 12900 ug/kg

葡萄糖酸氯己定 [18472-51-0] MSDS


SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Chlorhexidine digluconate solution    
    REACH No.        : A registration number is not available for this substance as the substance    
    or its uses are exempted from registration, the annual tonnage does not
    require a registration or the registration is envisaged for a later
    registration deadline.
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Acute aquatic toxicity (Category 1), H400
    Chronic aquatic toxicity (Category 2), H411
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    N Dangerous for the        R50/53    
    environment
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Pictogram
    Signal word        Warning    
    Hazard statement(s)
    H400        Very toxic to aquatic life.    
    H411        Toxic to aquatic life with long lasting effects.    
    Precautionary statement(s)
    P273        Avoid release to the environment.    
    Supplemental Hazard        none    
    Statements
  According to European Directive 67/548/EEC as amended.
    Hazard symbol(s)        N Dangerous for the environment    
    R-phrase(s)
    R50/53        Very toxic to aquatic organisms, may cause long-term adverse effects in    
    the aquatic environment.
    S-phrase(s)
    S61        Avoid release to the environment. Refer to special instructions/ Safety    
    data sheets.
  Other hazards - none

SECTION 3: Composition/information on ingredients
  Mixtures
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-
  tetraazatetradecanediamidine (2:1)
    CAS-No.        18472-51-0        Acute Tox. 4; Aquatic Acute 1;        20 - 25 %    
    EC-No.        242-354-0        Aquatic Chronic 1; H302,    
    H410
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-
  tetraazatetradecanediamidine (2:1)
    CAS-No.        18472-51-0        Xn, N, R22R50/53        20 - 25 %    
    EC-No.        242-354-0    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
  In case of eye contact
    Flush eyes with water as a precaution.
  If swallowed
    Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    no data available

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
    environment must be avoided.
  Methods and materials for containment and cleaning up
    Keep in suitable, closed containers for disposal.
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
    Recommended storage temperature: 2 - 8 °C
    Light sensitive.
  Specific end use(s)
    A part from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
  Personal protective equipment
  Eye/face protection
    Use equipment for eye protection tested and approved under appropriate government standards
    such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
    Full contact
    Material: Nitrile rubber
    Minimum layer thickness: 0,11 mm
    Break through time: 480 min
    Material tested:Dermatril® (KCL 740 / Z677272, Size M)
    Splash contact
    Material: Nitrile rubber
    Minimum layer thickness: 0,11 mm
    Break through time: 480 min
    Material tested:Dermatril® (KCL 740 / Z677272, Size M)
    data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300,     test method: EN374
    If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
    contact the supplier of the CE approved gloves. This recommendation is advisory only and must
    be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
    anticipated use by our customers. It should not be construed as offering an approval for any
    specific use scenario.
  Body Protection
    Impervious clothing., The type of protective equipment must be selected according to the
    concentration and amount of the dangerous substance at the specific workplace.
  Respiratory protection
    Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK
    (EU EN 14387) respirator cartridges. Use respirators and components tested and approved under
    appropriate government standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
    the environment must be avoided.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: liquid    
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        no data available    
    point
    f) Initial boiling point and no data available
    boiling range
    g) Flash point        no data available    
    h) Evaporation rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        no data available    
    flammability or
    explosive limits
    k) Vapour pressure        no data available    
    l) Vapour density        no data available    
    m) Relative density        1,06 g/cm3 at 25 °C    
    n) Water solubility        no data available    
    o) Partition coefficient: n- no data available
    octanol/water
    p) Auto-ignition        no data available    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    no data available

SECTION 10: Stability and reactivity
  Reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    no data available
  Incompatible materials
    Strong oxidizing agents
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    no data available
  Skin corrosion/irritation
    no data available
  Serious eye damage/eye irritation
    no data available
  Respiratory or skin sensitization
    no data available
  Germ cell mutagenicity
    no data available
  Carcinogenicity
    IARC:        No component of this product present at levels greater than or equal to 0.1% is identified as    
    probable, possible or confirmed human carcinogen by IARC.
  Reproductive toxicity
    no data available
  Specific target organ toxicity - single exposure
    no data available
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Additional Information
    RTECS: Not available
    To the best of our knowledge, the chemical, physical, and toxicological properties have not been
    thoroughly investigated.

SECTION 12: Ecological information
  Toxicity
    no data available
  Persistence and degradability
    no data available
  Bioaccumulative potential
    no data available
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    Very toxic to aquatic life.

SECTION 13: Disposal considerations
  Waste treatment methods
  Product
    Offer surplus and non-recyclable solutions to a licensed disposal company.
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: 3082        IMDG: 3082        IATA: 3082    
  UN proper shipping name
    ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (D-Gluconic acid,
    compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-
    tetraazatetradecanediamidine (2:1))
    IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (D-Gluconic acid,
    compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-
    tetraazatetradecanediamidine (2:1))
    IATA:        Environmentally hazardous substance, liquid, n.o.s. (D-Gluconic acid, compound with N,N''-    
    bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1))
  Transport hazard class(es)
    ADR/RID: 9        IMDG: 9        IATA: 9    
  Packaging group
    ADR/RID: III        IMDG: III        IATA: III    
  Environmental hazards
    ADR/RID: yes        IMDG Marine Pollutant: yes        IATA: yes    
  Special precautions for user
  Further information
    EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination
    packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids.

SECTION 15: Regulatory information
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
  Safety, health and environmental regulations/legislation specific for the substance or mixture
    no data available
  Chemical Safety Assessment
    For this product a chemical safety assessment was not carried out

SECTION 16: Other information
  Full text of H-Statements referred to under sections 2 and 3.
    Acute Tox.        Acute toxicity    
    Aquatic Acute        Acute aquatic toxicity    
    Aquatic Chronic        Chronic aquatic toxicity    
    H302        Harmful if swallowed.    
    H400        Very toxic to aquatic life.    
    H410        Very toxic to aquatic life with long lasting effects.    
    H411        Toxic to aquatic life with long lasting effects.    
  Full text of R-phrases referred to under sections 2 and 3
    N        Dangerous for the environment    
    R22        Harmful if swallowed.    
    R50/53        Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic    
    environment.
    Xn        Harmful    
  Further information
    Copyright 2013 Co. LLC. License granted to make unlimited paper copies for internal use
    only.
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

葡萄糖酸氯己定 [18472-51-0] 分子结构与计算化学数据

计算化学数据

1、   氢键供体数量:18

2、   氢键受体数量:24

3、   可旋转化学键数量:23

4、   互变异构体数量:36

5、   拓扑分子极性表面积(TPSA):455

6、   重原子数量:60

7、   表面电荷:0

8、   复杂度:819

9、   同位素原子数量:0

10、   确定原子立构中心数量:8

11、   不确定原子立构中心数量:0

12、   确定化学键立构中心数量:2

13、   不确定化学键立构中心数量:0

14、   共价键单元数量:3

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佛山晟熠生物科技有限公司

产品介绍:
产品名称:葡萄糖酸氯己定 现货 Cas号:18472-51-0 纯度:20% 包装信息:桶装kg 价格:31.0元
联系方式:
联系人:熊贝 电话:18064675239 手机:18024945277

武汉联商网科技有限公司

产品介绍:
产品名称:葡萄糖酸氯己定 Cas号:18472-51-0 纯度:20% 包装信息:200/塑料桶kg,淡黄液体,20% 价格:洽谈
联系方式:
联系人:熊经理 电话:18872220794 手机:18872220794

中山联久生物科技有限公司

产品介绍:
产品名称:葡萄糖酸氯己定 Cas号:18472-51-0 纯度:20% 包装信息:200/塑料桶 kg 价格:35.0元
联系方式:
联系人:汪凌宇 电话:18125352747 手机:18125352747

武汉共创科技有限公司

产品介绍:
产品名称:葡萄糖酸氯己定 Cas号:18472-51-0 纯度:20% 包装信息:200kg 价格:35.0元
联系方式:
联系人:罗阳 电话:18908446935 手机:18908446935

湖北鑫鸣泰化学有限公司

产品介绍:
产品名称:葡萄糖酸氯己定 Cas号:18472-51-0 纯度:99% 包装信息:100kg,200kg 价格:1.0元 - 1.0元
联系方式:
联系人:黄 电话:027-50662354 手机:13264726139

湖北鑫鸣泰化学有限公司

产品介绍:
产品名称:葡萄糖酸氯已定 Cas号:18472-51-0 纯度:99% 包装信息:25/桶kg 价格:1.0元
联系方式:
联系人:黄经理 电话:027-51833411 手机:13237166274