2-氯-5-氯甲基吡啶

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学
  • 上游产品
  • 下游产品

2-氯-5-氯甲基吡啶 基本信息

中文名称:
2-氯-5-氯甲基吡啶 
中文别名:
2-氯-5-氯甲基吡啶;
2-氯-5-(氯甲基)吡啶;
二氯五氯甲基吡啶;
2,5-二氯甲基吡啶 
英文名称:
2-Chloro-5-chloromethylpyridine
英文别名:
2-Chloro-5-chloromethylpyridine;
2-chloropyridyl-5-methylene chloride;
2-Chloro-5-pyridylMethyl chloride;
5-chloromethyl-2-chloropyridine;
6-Chlo;
imidacloprid impurity;
2,5-DICHLORO-4-METHYL-PYRIDINE;
2-Chloro-5-Chloro-Me;
AURORA KA-6694;
2-chloro-5-chloromethyl-pyridine;
2-Chlor-5-Chlormethylpyridine;
6-chloro-nicotinyl chloride 
CAS No.:
70258-18-3
分 子 式:

C6H5Cl2N

分 子 量:
162.02
精确分子量:
160.98000
PSA:
12.89000
MDL:
MFCD00125366
EINECS:
000-000-0
BRN:
1635690
InChI:
InChI=1/C6H5Cl2N/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3
危险品标志:

CorrosiveC;IrritantXi;FlammableF;

风险术语:

R22;R34;R36;R10

安全术语:

S26;S36/37/39;S45;S25;S36;S16

分子结构式:
SDS:
查看

2-氯-5-氯甲基吡啶 制备方法及用途

制备方法

用作农药吡虫啉和啶虫咪中间体;2-氯-5-氯甲基吡啶是杀虫剂吡虫啉、啶虫脒的中间体。

合成制备方法

目前工业上多采用由2-氯-5-甲基吡啶在催化剂存在下支链氯化的方法得到2-氯-5-氯甲基吡啶。将2-氯-5-甲基吡啶和溶剂加入到反应斧中,加入催化剂,回流并通氯气进行反应。

用途简介

用途

用作杀虫剂吡虫啉和啶虫咪的合成中间体。

2-氯-5-氯甲基吡啶 物化性质

外观与性状:
米色晶体
密度:
1.324 g/cm3
熔点:
37-42 °C(lit.)
沸点:
249.8ºC at 760 mmHg
闪点:
>230 °F
折射率:
1.547
存储条件/存储方法:

存放在密封容器内,并放在阴凉,干燥处。储存的地方必须上锁,钥匙必须交给技术专家和他们的助手保管。储存的地方必须远离氧化剂。

稳定性相关:

远离氧化物。

其它信息:

1.       性状:白色结晶

2.       密度(g/mL,25/4℃):未确定

3.       相对蒸汽密度(g/mL,空气=1):未确定

4.       熔点(ºC):35~36

5.       沸点(ºC,常压):未确定

6.       沸点(ºC,400Pa):88~90

7.       折射率:未确定

8.       闪点(ºC):>110

9.       比旋光度(º):未确定

10.    自燃点或引燃温度(ºC):未确定

11.    蒸气压(kPa,25ºC):未确定

12.    饱和蒸气压(kPa,60ºC):未确定

13.    燃烧热(KJ/mol):未确定

14.    临界温度(ºC):未确定

15.    临界压力(KPa):未确定

16.    油水(辛醇/水)分配系数的对数值:未确定

17.    爆炸上限(%,V/V):未确定

18.    爆炸下限(%,V/V):未确定

19.    溶解性:工业品为橘红色黏稠状液体,有刺激性气味,溶于多种有机溶剂和有机酸等。

2-氯-5-氯甲基吡啶 安全信息

包装等级:
II
海关代码:
2933399010
WGK_Germany:
3
德国有关水污染物质的分类清单
危险类别码:
R34
安全说明:
S26-S36/37/39-S45-S25
安全标志:
S26:万一接触眼睛,立即使用大量清水冲洗并送医诊治。
S45:出现意外或者感到不适,立刻到医生那里寻求帮助(最好带去产品容器标签)。
:
危险标志:
C:Corrosive

2-氯-5-氯甲基吡啶 毒理性

毒理学数据:

强刺激性,避免与皮肤接触。

生态数据:

对水稍微有危害的,不要让未稀释或者大量产品接触地下水,水道或者污水系统。若无政府许可,勿将材料排入周围环境。

2-氯-5-氯甲基吡啶 MSDS

Name: 2-Chloro-5-chloromethylpyridine tech. 90% Material Safety Data Sheet
Synonym:
CAS: 70258-18-3
Section 1 - Chemical Product   MSDS Name:2-Chloro-5-chloromethylpyridine tech. 90% Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
70258-18-3 2-Chloro-5-chloromethylpyridine 90 unlisted
Hazard Symbols: C
Risk Phrases: 34

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Causes burns.
Potential Health Effects
Eye:
Causes eye burns.
Skin:
Causes skin burns.
Ingestion:
Causes gastrointestinal tract burns.
Inhalation:
Causes chemical burns to the respiratory tract.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do NOT induce vomiting. Get medical aid immediately.
If victim is fully conscious, give a cupful of water. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Do not get in eyes, on skin, or on clothing. Do not breathe dust. Use only with adequate ventilation.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Corrosives area.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 70258-18-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Crystals
Color: beige
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 37-42 deg C
Autoignition Temperature: Not available.
Flash Point: > 230 deg F (> 110.00 deg C)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C6H5Cl2N
Molecular Weight: 161.9477

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, acid chlorides, acid anhydrides.
Hazardous Decomposition Products:
Hydrogen chloride, carbon monoxide, oxides of nitrogen, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 70258-18-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-Chloro-5-chloromethylpyridine - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: Corrosive Solid, Acidic, Organic, N.O.S.
Hazard Class: 8
UN Number: 3261
Packing Group: III
IMO
Shipping Name: Corrosive Solid, Acidic, Organic, N.O.S.
Hazard Class: 8
UN Number: 3261
Packing Group: III
RID/ADR
Shipping Name: Corrosive Solid, Acidic, Organic, N.O.S.
Hazard Class: 8
UN Number: 3261
Packing group:

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 25 Avoid contact with eyes.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 70258-18-3: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 70258-18-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 70258-18-3 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

2-氯-5-氯甲基吡啶 分子结构与计算化学数据

分子结构数据

1、   摩尔折射率:39.00

2、   摩尔体积(cm3/mol):122.3

3、   等张比容(90.2K):312.5

4、   表面张力(dyne/cm):42.6

5、   极化率(10-24cm3):15.46

 

计算化学数据

1.疏水参数计算参考值(XlogP):2.2

2.氢键供体数量:0

3.氢键受体数量:1

4.可旋转化学键数量:1

5.互变异构体数量:无

6.拓扑分子极性表面积12.9

7.重原子数量:9

8.表面电荷:0

9.复杂度:87.1

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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