脱氢野百合碱

密度：

1.43g/cm3

熔点：

30-33°C

沸点：

557ºC at 760mmHg

闪点：

290.6ºC

折射率：

1.62

蒸汽压：

3.06E-13mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :

RC1250000

CHEMICAL NAME :

20-Norcrotalanan-11,15-dione, 3,8-didehydro-14,19-dihydro-12,13-dihydroxy-, (13-alpha,14- alpha)-

CAS REGISTRY NUMBER :

23291-96-5

LAST UPDATED :

199606

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C16-H21-N-O6

MOLECULAR WEIGHT :

323.38

WISWESSER LINE NOTATION :

T55-11- 1A P EN IOV NVO BU FUTJ K1 LQ L1 MQ M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

16 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes Liver - other changes

REFERENCE :

CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 12,299,1976

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes

REFERENCE :

JPTLAS Journal of Pathology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.97- 1969- Volume(issue)/page/year: 100,169,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3 mg/kg/5W-I

TOXIC EFFECTS :

Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :

JPTLAS Journal of Pathology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.97- 1969- Volume(issue)/page/year: 118,121,1976 ** TUMORIGENIC DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1504 mg/kg/47W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

REFERENCE :

CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 17,61,1982