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奥芬那君相关物质C 基本信息
- 中文名称：
- 奥芬那君相关物质C
- 中文别名：
- N-去甲奧芬那君盐酸盐盐酸脱氧邻甲苯海明;
枸櫞酸奧芬那君杂质C;
枸櫞酸邻甲苯海拉明杂质C
- 英文名称：
- Ethanamine,N-methyl-2-[(2-methylphenyl)phenylmethoxy]-, hydrochloride (1:1)
- 英文别名：
- tofenacin hydrochloride;
Tofenacin Hydrochloride Salt;
Orphenadrine Related Compound C (20 mg) (N-methyl-[2-(2-methylbenhydryloxy)ethyl]amine hydrochloride)
- CAS No.：
- 10488-36-5
- 分 子 式：
- C17H21NO.ClH
- 分 子 量：
- 291.85
- 精确分子量：
- 291.13900
- PSA：
- 21.26000
- EINECS：
- 234-011-9
- 安全术语：
- Poison by ingestion, intraperitoneal, intravenous and subcutaneous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx. Used as an antidepressant.
- 分子结构式：
-
- SDS：
- 查看
奥芬那君相关物质C 物化性质
- 熔点：
- 147-148℃ (ethanol ethyl ether )
- 沸点：
- 353.3ºC at 760mmHg
- 闪点：
- 151.8ºC
- 蒸汽压：
- 3.61E-05mmHg at 25°C
奥芬那君相关物质C 安全信息
- WGK_Germany：
- 3
德国有关水污染物质的分类清单
奥芬那君相关物质C 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KR9100000
- CHEMICAL NAME :
- Ethylamine,
N-methyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-,
hydrochloride
- CAS REGISTRY NUMBER :
- 10488-36-5
- LAST UPDATED :
- 199510
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C17-H21-N-O.Cl-H
- MOLECULAR WEIGHT :
- 291.85
- WISWESSER LINE NOTATION :
- 1M2OYR&R B1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,375,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 72 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory stimulation
Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
spasmolytic)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 177,28,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,375,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 182 mg/kg
- TOXIC EFFECTS :
- Behavioral - alteration of operant conditioning
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 177,28,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 55 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 177,28,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 82 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 177,28,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,375,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,375,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 92 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
spasmolytic)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 177,28,1969
