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TOS-LYS-CMK 基本信息
- 中文名称：
- TOS-LYS-CMK
- 中文别名：
- TOS-LYS-CMK
- 英文名称：
- Benzenesulfonamide,N-[(1S)-5-amino-1-(2-chloroacetyl)pentyl]-4-methyl-
- 英文别名：
- TLCK;
N-Tosyl-L-lysine chloromethyl ketone;
N-p-Tosyl-L-lysyl chloromethyl ketone;
TOS-LYS-CHLOROMETHYLKETONE HCL;
TOSYL-L-LYSYL-CHLOROMETHANE HCL;
TOSYL-L-LYSINE CHLOROMETHYLKETONE HCL;
TOS-LYS-CMK HCL;
Tosyl-L-lysine chloromethyl ketone
- CAS No.：
- 2364-87-6
- 分 子 式：
- C14H21ClN2O3S
- 分 子 量：
- 332.88
- 精确分子量：
- 368.07300
- PSA：
- 97.64000
- EINECS：
- 224-266-4
- 危险品标志：
- 风险术语：
- 36/37/38
- 安全术语：
- Poison by intraperitoneal and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and SOx. See also KETONES.
- 分子结构式：
-
- SDS：
- 查看
TOS-LYS-CMK 物化性质
- 密度：
- 1.242g/cm3
- 熔点：
- -165ºC (dec.)
- 沸点：
- 509.8ºC at 760mmHg
- 闪点：
- 262.1ºC
TOS-LYS-CMK 安全信息
- 危险类别码：
- R36/37/38
- 危险标志：
- Xi: Irritant;
TOS-LYS-CMK 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XT5150000
- CHEMICAL NAME :
- p-Toluenesulfonamide,
N-(5-amino-1-(chloroacetyl)pentyl)-, L-
- CAS REGISTRY NUMBER :
- 2364-87-6
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C14-H21-Cl-N2-O3-S
- MOLECULAR WEIGHT :
- 332.88
- WISWESSER LINE NOTATION :
- Z4YVGMSWR D1 -L
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 59 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
Liver - hepatitis (hepatocellular necrosis), diffuse
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,227,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 64 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
Liver - hepatitis (hepatocellular necrosis), diffuse
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,227,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 480 mg/kg/4W-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,227,1980
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 280 mg/kg
- SEX/DURATION :
- female 28 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 70,60,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intrauterine
- DOSE :
- 160 mg/kg
- SEX/DURATION :
- female 2 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 25,954,1974
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravaginal
- DOSE :
- 280 mg/kg
- SEX/DURATION :
- female 28 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 70,60,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravaginal
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W.
Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:
20,1045,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravaginal
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- female 5 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - mating performance (e.g. # sperm positive females
per # females mated; # copulations per # estrus cycles)
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W.
Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:
20,1045,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravaginal
- DOSE :
- 7500 ug/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 31,278,1972
