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3-(甲基亚硝基氨基).丙腈 基本信息
- 中文名称：
- 3-(甲基亚硝基氨基).丙腈
- 中文别名：
-
- 英文名称：
- Propanenitrile,3-(methylnitrosoamino)-
- 英文别名：
- Propanenitrile, 3-(methylnitrosoamino)-;
3-(Methylnitrosamino)propionitrile;
N-(2-cyanoethyl)-N-methylnitrous amide
- CAS No.：
- 60153-49-3
- 分 子 式：
- C4H7N3O
- 分 子 量：
- 113.14
- 精确分子量：
- 113.05891
- PSA：
- 56.5 A2
- InChI：
- The Key: HZDLDFBKYBGNHG-UHFFFAOYSA-N
- 安全术语：
- Confirmed carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.
- 分子结构式：
-
- SDS：
- 查看
3-(甲基亚硝基氨基).丙腈 物化性质
- 密度：
- 1.07±0.1 g/cm3
- 沸点：
- 311.0±25.0 °C
- 闪点：
- 141.9±23.2 °C
- 水溶解性：
- Soluble (85 g/L)
- 折射率：
- 1.492
- 蒸汽密度：
- 5.80E-4 Torr
3-(甲基亚硝基氨基).丙腈 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UG4030000
- CHEMICAL NAME :
- Propionitrile, 3-(methylnitrosamino)-
- CAS REGISTRY NUMBER :
- 60153-49-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C4-H7-N3-O
- MOLECULAR WEIGHT :
- 113.14
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1036 mg/kg/54W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 103 mg/kg/20W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 622 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
Gastrointestinal - tumors
- TYPE OF TEST :
- DNA damage
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 221,263,1989
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 37,263,1985
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 37,263,1985
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
