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泼尼松龙法呢酯 基本信息
- 中文名称：
- 泼尼松龙法呢酯
- 中文别名：
- 泼尼松龙法呢酯
- 英文名称：
- Pregna-1,4-diene-3,20-dione,11,17-dihydroxy-21-[[(2E,6E)-3,7,11-trimethyl-1-oxo-2,6,10-dodecatrien-1-yl]oxy]-,(11b)-
- 英文别名：
- [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoate;
Prednisolone farnesylate;
Pregna-1,4-diene-3,20-dione,11,17-dihydroxy-21-((3,7,11-trimethyl-1-oxo-2,6,10-dodecatrienyl)-oxy)-,(11beta,21(2E,6E));
Farnerate gel;
Farnerate (TN);
Farnezone
- CAS No.：
- 118244-44-3
- 分 子 式：
- C36H50O6
- 分 子 量：
- 0
- 精确分子量：
- 578.36100
- PSA：
- 100.90000
- 分子结构式：
-
- SDS：
- 查看
泼尼松龙法呢酯 物化性质
- 密度：
- 1.15g/cm3
- 沸点：
- 712.5ºC at 760mmHg
- 闪点：
- 217.5ºC
- 折射率：
- 1.569
- 蒸汽压：
- 1.88E-23mmHg at 25°C
泼尼松龙法呢酯 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU3832200
- CHEMICAL NAME :
- Pregna-1,4-diene-3,20-dione,
11,17-dihydroxy-21-((3,7,11-trimethyl-1-oxo-2,6,10-
dodecatrienyl)-oxy)-, (11beta,21(2E,6E))-
- CAS REGISTRY NUMBER :
- 118244-44-3
- LAST UPDATED :
- 199306
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C36-H50-O6
- MOLECULAR WEIGHT :
- 578.86
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1456 mg/kg/13W-I
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight
Blood - changes in leukocyte (WBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl
3),49,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 728 mg/kg/52W-I
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), zonal
Endocrine - changes in spleen weight
Biochemical - Metabolism (Intermediary) - other proteins
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl
3),91,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2730 mg/kg/13W-I
- TOXIC EFFECTS :
- Blood - changes in leukocyte (WBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
Related to Chronic Data - death
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl
3),1,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 291 mg/kg/13W-I
- TOXIC EFFECTS :
- Endocrine - changes in adrenal weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - lipids including transport
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl
3),123,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 291 mg/kg/52W-I
- TOXIC EFFECTS :
- Endocrine - changes in adrenal weight
Blood - changes in leukocyte (WBC) count
Biochemical - Metabolism (Intermediary) - other proteins
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl
3),161,1992
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- >11 mg/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Specific Developmental Abnormalities - hepatobiliary system
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl
3),217,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 3250 ug/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl
3),241,1992
