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膦西泮 基本信息
- 中文名称：
- 膦西泮
- 中文别名：
- 膦西泮
- 英文名称：
- 2H-1,4-Benzodiazepin-2-one,7-chloro-1-[(dimethylphosphinyl)methyl]-1,3-dihydro-5-phenyl-
- 英文别名：
- 7-chloro-1-(dimethylphosphorylmethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one;
2H-1,4-Benzodiazepin-2-one,7-chloro-1-((dimethylphosphinyl)methyl)-1,3-dihydro-5-phenyl;
Fosazepam;
7-Chloro-1-(dimethylphosphinmethyl)-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one;
7-chloro-1-(dimethylphosphinoyl-methyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;
HR-930;
2H-1,4-Benzodiazepin-2-one,1,3-dihydro-7-chloro-1-((dimethylphosphinyl)methyl)-5-phenyl;
Fosazepamum [INN-Latin];
7-Chloro-1-((dimethylphosphinyl)methyl)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
- CAS No.：
- 35322-07-7
- 分 子 式：
- C18H18ClN2O2P
- 分 子 量：
- 360.80
- 精确分子量：
- 360.07900
- PSA：
- 59.55000
- InChI：
- The Key: JMYCGCXYZZHWMO-UHFFFAOYSA-N
- 安全术语：
- Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of Cl−, POx, and NOx. See also DIAZEPAM.
- 分子结构式：
-
- SDS：
- 查看
膦西泮 物化性质
- 密度：
- 1.31g/cm3
- 沸点：
- 638ºC at 760mmHg
- 闪点：
- 339.6ºC
- 折射率：
- 1.628
膦西泮 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DF2369000
- CHEMICAL NAME :
- 2H-1,4-Benzodiazepin-2-one,
1,3-dihydro-7-chloro-1-((dimethylphosphinyl)methyl)-5
-phenyl-
- CAS REGISTRY NUMBER :
- 35322-07-7
- BEILSTEIN REFERENCE NO. :
- 0896155
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C18-H18-Cl-N2-O2-P
- MOLECULAR WEIGHT :
- 360.80
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3110 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 10,265,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 10,265,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1740 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 10,265,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 10,265,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 10,265,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 10,265,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 550 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 10,265,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 285 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 10,265,1975
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 14 gm/kg/4W-C
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea
Liver - changes in liver weight
Related to Chronic Data - death
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 10,265,1975
湖北恩星生物科技有限公司
- 产品介绍：
-
产品名称：膦西泮
Cas号：35322-07-7
纯度：
包装信息：100kg,200kg,300kg,400kg,500kg
价格：64.0元 - 100.0元
- 联系方式：
-
联系人：邵经理
电话：16621771607
手机：16621771607
