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麦角新碱 基本信息
- 中文名称：
- 麦角新碱
- 中文别名：
- 麦角新碱;
爱谷米特邻碱
- 英文名称：
- ergometrine
- 英文别名：
- Ergometrine;
secacornin;
secometrin;
ergotocine;
Ergobasin;
ergometrin;
Ergotrane;
basergin;
ERGONOVINE;
ermetrine
- CAS No.：
- 60-79-7
- 分 子 式：
-
C19H23N3O2
- 分 子 量：
- 325.39
- 精确分子量：
- 325.17900
- PSA：
- 68.36000
- InChI：
- The Key: WVVSZNPYNCNODU-UHFFFAOYSA-N
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
- 分子结构式：
-
- SDS：
- 查看
麦角新碱 安全信息
- 危险类别码：
- 23/24/25
- 安全说明：
- 36/37/39-45
麦角新碱 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KE5075000
- CHEMICAL NAME :
- Ergoline-8-beta-carboxamide,
9,10-didehydro-N-((S)-2-hydroxy-1-methylethyl)-6-meth
yl-
- CAS REGISTRY NUMBER :
- 60-79-7
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C19-H23-N3-O2
- MOLECULAR WEIGHT :
- 325.45
- WISWESSER LINE NOTATION :
- T C6656 1A P GN LM CUTT&&J EVMY1&1Q G1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Human - infant
- DOSE/DURATION :
- 93 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- SAMJAF South African Medical Journal. (Medical Assoc. of South Africa,
Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-
Volume(issue)/page/year: 46,2052,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Human - infant
- DOSE/DURATION :
- 138 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB
560B, Kennebunkport, ME 04046) V.1- 1926- Volume(issue)/page/year:
55,68,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human - infant
- DOSE/DURATION :
- 176 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- JOGBAS Journal of Obstetrics and Gynaecology of the British Commonwealth.
(London, UK) V.68-81, 1961-74. For publisher information, see BJOGAS.
Volume(issue)/page/year: 79,764,1972
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 119,1302,1935
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 144 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 105,130,1952
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 144 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 98,335,1954
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 6 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New
series: V.1-49, 1935-78. For publisher information, see HEPHD2.
Volume(issue)/page/year: 6,180,1938
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,107,1973
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 119,1302,1935
