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曲莫前列素 基本信息
- 中文名称：
- 曲莫前列素
- 中文别名：
- 曲莫前列素
- 英文名称：
- Prosta-5,13-dien-1-oicacid, 15-hydroxy-11,16,16-trimethyl-9-oxo-, (5Z,11a,13E,15R)-
- 英文别名：
- TRIMOPROSTIL
- CAS No.：
- 69900-72-7
- 分 子 式：
- C23H38O4
- 分 子 量：
- 0
- 精确分子量：
- 378.27700
- PSA：
- 74.60000
- 分子结构式：
-
- SDS：
- 查看
曲莫前列素 物化性质
- 密度：
- 1.043g/cm3
- 沸点：
- 528.2ºC at 760 mmHg
- 闪点：
- 287.3ºC
- 折射率：
- 1.527
曲莫前列素 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UK8010000
- CHEMICAL NAME :
- Prosta-5,13-dien-1-oic acid,
15-hydroxy-9-oxo-11,16,16-trimethyl-,
(5Z,11-alpha,13E,15R)-
- CAS REGISTRY NUMBER :
- 69900-72-7
- LAST UPDATED :
- 199009
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C23-H38-O4
- MOLECULAR WEIGHT :
- 378.61
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 22 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho
Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952-
Volume(issue)/page/year: 35,2199,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 17 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho
Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952-
Volume(issue)/page/year: 35,2199,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho
Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952-
Volume(issue)/page/year: 35,2199,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 39 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho
Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952-
Volume(issue)/page/year: 35,2199,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 62 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho
Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952-
Volume(issue)/page/year: 35,2199,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho
Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952-
Volume(issue)/page/year: 35,2199,1986
