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2-氯乙基-N-亚硝基脲烷 基本信息
- 中文名称：
- 2-氯乙基-N-亚硝基脲烷
- 中文别名：
- 2-CHLOROETHYL-N-NITROSOURETHANE
- 英文名称：
- Carbamic acid,(2-chloroethyl)nitroso-, ethyl ester (7CI,8CI,9CI)
- 英文别名：
- ethyl N-(2-chloroethyl)-N-nitrosocarbamate;
TL 154;
2-Chloroethyl-N-nitrosourethane
- CAS No.：
- 6296-45-3
- 分 子 式：
- C5H9ClN2O3
- 分 子 量：
- 180.61
- 精确分子量：
- 180.03000
- PSA：
- 58.97000
- InChI：
- The Key: NFCXERZWGPTYNW-UHFFFAOYSA-N
- 安全术语：
- Poison by inhalation, ingestion, and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Many N-nitroso compounds are carcinogens. See also CARBAMATES and N-NITROSO COMPOUNDS. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
- 分子结构式：
-
- SDS：
- 查看
2-氯乙基-N-亚硝基脲烷 物化性质
- 密度：
- 1.3g/cm3
- 沸点：
- 215.4ºC at 760 mmHg
- 闪点：
- 84.1ºC
- 折射率：
- 1.493
- 存储条件/存储方法：
- 库房通风低温干燥,与食品原料分开储运
2-氯乙基-N-亚硝基脲烷 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EZ2100000
- CHEMICAL NAME :
- Carbamic acid, (2-chloroethyl)nitroso-, ethyl ester
- CAS REGISTRY NUMBER :
- 6296-45-3
- BEILSTEIN REFERENCE NO. :
- 1781530
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C5-H9-Cl-N2-O3
- MOLECULAR WEIGHT :
- 180.61
- WISWESSER LINE NOTATION :
- ON2OVM2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
Gastrointestinal - changes in structure or function of esophagus
Gastrointestinal - alteration in gastric secretion
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 330 mg/m3/10M
- TOXIC EFFECTS :
- Behavioral - irritability
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6500 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - pleural effusion
Skin and Appendages - dermatitis, other (after systemic exposure)
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 75 mg/m3/10M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 330 mg/m3/10M
- TOXIC EFFECTS :
- Behavioral - irritability
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 330 mg/m3/10M
- TOXIC EFFECTS :
- Behavioral - irritability
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 500 nmol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
43,175,1983
