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锗螺胺 基本信息
- 中文名称：
- 锗螺胺
- 中文别名：
- 锗螺胺
- 英文名称：
- 2-Aza-8-germaspiro[4.5]decane-2-propanamine,8,8-diethyl-N,N-dimethyl-, hydrochloride (1:2)
- 英文别名：
- 2-Aza-8-germaspiro[4.5]decane-2-propanamine, 8,8-diethyl-N,N-dimethyl-, hydrochloride (1:2);
3-(8,8-diethyl-2-aza-8-germaspiro[4.5]decan-2-yl)-N,N-dimethylpropan-1-amine,dihydrochloride;
Spirogermanium hydrochloride;
Spirogermanium dihydrochloride;
2-Aza-8-germaspiro(4.5)decane-2-propanamine,8,8-diethyl-N,N-dimethyl-,dihydrochloride;
Spiro-32;
8,8-Diethyl-N,N-dimethyl-2-aza-8-germaspiro(4.5)decane-2-propanamine dihydrochloride;
Spirogermanium hydrochloride (USAN)
- CAS No.：
- 41992-22-7
- 分 子 式：
- C17H36GeN2.2ClH
- 分 子 量：
- 414.06
- 精确分子量：
- 378.18600
- PSA：
- 6.48000
- 安全术语：
- Poison by subcutaneous, intramuscular, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and HCl. See also GERMANIUM COMPOUNDS.
- 分子结构式：
-
- SDS：
- 查看
锗螺胺 物化性质
- 熔点：
- 287-288 °C
- 沸点：
- 382.8ºC at 760mmHg
- 闪点：
- 165.8ºC
锗螺胺 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CL7618500
- CHEMICAL NAME :
- 2-Aza-8-germaspiro(4.5)decane-2-propanamine,
8,8-diethyl-N,N-dimethyl, dihydrochloride
- CAS REGISTRY NUMBER :
- 41992-22-7
- LAST UPDATED :
- 198605
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C17-H36-Ge-N2.2Cl-H
- MOLECULAR WEIGHT :
- 414.06
- WISWESSER LINE NOTATION :
- T6-GE- DXTJ A2 A2 D-& CT5N CXTJ A3N1&1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 107 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary,
Developmental Therapeutics Program. (Bethesda, MD 20205)
Volume(issue)/page/year: JAN1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 210 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary,
Developmental Therapeutics Program. (Bethesda, MD 20205)
Volume(issue)/page/year: JAN1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 41500 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB264-117
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 119 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Blood - hemorrhage
Blood - other changes
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For
publisher information, see JNCIEQ. Volume(issue)/page/year: 64,1207,1980
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For
publisher information, see JNCIEQ. Volume(issue)/page/year: 64,1207,1980
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For
publisher information, see JNCIEQ. Volume(issue)/page/year: 64,1207,1980
锗螺胺 分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:2
3.氢键受体数量:2
4.可旋转化学键数量:6
5.互变异构体数量:无
6.拓扑分子极性表面积:6.5
7.重原子数量:22
8.表面电荷:0
9.复杂度:289
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:3
