产品供求
一叶秋碱
- 基本信息
- 制备方法及用途
- 物化性质
- 安全信息
- 毒理性
一叶秋碱 基本信息
- 中文名称：
- 一叶秋碱
- 中文别名：
- 一叶秋碱;
一叶萩碱;
叶秋碱
- 英文名称：
- 8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one,9,10,11,11a-tetrahydro-, (6S,11aR,11bS)-
- 英文别名：
- Securinine;
Securinan-11-on;
1,2,3,4,10,10a-Hexahydro-10-hydroxy;
SECURAN-11-ONE;
securinin;
Securan one
- CAS No.：
- 5610-40-2
- 分 子 式：
- C13H15NO2
- 分 子 量：
- 217.29
- 精确分子量：
- 217.11000
- PSA：
- 29.54000
- InChI：
- The Key: SWZMSZQQJRKFBP-WZRBSPASSA-N
- 危险品标志：
T
- 风险术语：
- 23/24/25
- 安全术语：
- Poison by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
- 分子结构式：
-
- SDS：
- 查看
一叶秋碱 制备方法及用途
制备方法
抗菌活性;对中枢神经系统有兴奋作用;抗肿瘤作用
用途简介
一叶秋碱 物化性质
- 密度：
- 1.3 g/cm3
- 熔点：
- 140-142ºC
- 沸点：
- 459ºC at 760 mmHg
- 闪点：
- 197ºC
- 折射率：
- 1.633
一叶秋碱 安全信息
- 危险类别码：
- R23/24/25
- 危险标志：
- T: Toxic;
一叶秋碱 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VS4115000
- CHEMICAL NAME :
- Securinine, (-)-
- CAS REGISTRY NUMBER :
- 5610-40-2
- LAST UPDATED :
- 199201
- DATA ITEMS CITED :
- 18
- MOLECULAR FORMULA :
- C13-H15-N-O2
- MOLECULAR WEIGHT :
- 217.29
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 41 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15100 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 17400 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-
Volume(issue)/page/year: 83,800,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 270 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 31800 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20420 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6230 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 19320 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >10 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- >54 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- >100 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Ear) - change in acuity
Behavioral - somnolence (general depressed activity)
Kidney, Ureter, Bladder - other changes
- REFERENCE :
- CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1915-
Suspended 1967-72. Volume(issue)/page/year: 54,234,1974
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 50 mg/kg
- SEX/DURATION :
- male 5 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
- REFERENCE :
- NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year:
52,483,1965
湖北诺纳科技有限公司
- 产品介绍：
-
产品名称：一叶秋碱
Cas号：5610-40-2
纯度：99%
包装信息：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶
价格：1.0元 - 25.0元
- 联系方式：
-
联系人：张经理
电话：027-59209883
手机：17386169806
上海吉至生化科技有限公司
- 产品介绍：
-
产品名称：一叶萩碱
Cas号：5610-40-2
纯度：95%
包装信息：100mgea,50mgea
价格：1,286.0元 - 2,353.0元
- 联系方式：
-
联系人：江珊
电话：021-57520831
手机：15316869680
湖北魏氏化学试剂股份有限公司
- 产品介绍：
-
产品名称：(6S,11aR,11bS)-6,8,9,10,11,11a-六氢-2H-6,11b-甲桥呋喃并[2,3-c]吡啶并[1,2-a]氮杂卓-2-酮
Cas号：5610-40-2
纯度：95%
包装信息：25mg
价格：636.0元
- 联系方式：
-
联系人：刘涛
电话：027-59101766
手机：13125137661
北京百灵威科技有限公司
- 产品介绍：
-
产品名称：一叶萩碱 952076
Cas号：5610-40-2
纯度：99%，来源于一叶秋
包装信息：20mg
价格：洽谈
- 联系方式：
-
联系人：翟先生
电话：18210857532
手机：18210857532
成都草源康生物科技有限公司
- 产品介绍：
-
产品名称：一叶萩碱
Cas号：5610-40-2
纯度：98%
包装信息：20mg
价格：洽谈
- 联系方式：
-
联系人：杨经理
电话：13438890025
手机：13438890025
上海源叶生物科技有限公司
- 产品介绍：
-
产品名称：一叶萩碱
Cas号：5610-40-2
纯度：HPLC≥98%
包装信息：20mg
价格：540.0元
- 联系方式：
-
联系人：Yuki
电话：021-61845781
手机：13585604150
成都乐美天医药科技有限公司
- 产品介绍：
-
产品名称：一叶萩碱
Cas号：5610-40-2
纯度：HPLC≥98%
包装信息：20/支mg
价格：洽谈
- 联系方式：
-
联系人：梁
电话：028-85003950
手机：17313084125
宝鸡市国康海思化学技术有限公司
- 产品介绍：
-
产品名称：一叶秋碱
Cas号：5610-40-2
纯度：98
包装信息：1kg
价格：洽谈
- 联系方式：
-
联系人：杨经理
电话：0917-3909592
手机：13892490616
湖北魏氏化学试剂股份有限公司
- 产品介绍：
-
产品名称：(6S,11aR,11bS)-6,8,9,10,11,11a-六氢-2H-6,11b-甲桥呋喃并[2,3-c]吡啶并[1,2-a]氮杂卓-2-酮
Cas号：5610-40-2
纯度：95%
包装信息：25mg
价格：636.0元
- 联系方式：
-
联系人：张经理
电话：027-59102966
手机：18717199209
武汉天植生物技术有限公司
- 产品介绍：
-
产品名称：一叶萩碱
Cas号：5610-40-2
纯度：>=98%
包装信息：1
价格：1.0元
- 联系方式：
-
联系人：欧阳
电话：13545281503
手机：18607104898
