卡茄碱

基本信息
物化性质
安全信息
毒理性

卡茄碱基本信息

中文名称：: 卡茄碱

中文别名：: 卡茄碱;
α-卡茄碱;
Oxybendazole;
methyl N-(5-propoxy-3H-benzoimidazol-2-yl)carbamate;
methyl (6-propoxy-1H-benzimidazol-2-yl)carbamate;
Oxbendazole;
amifostine;
Propanoyl chloride, 2-bromo-2-methyl-;
AI3-16502;
NSC 76003;
1-Pentanol, 5-chloro-, acetate;
4,4'-Methylene-bis(2-ethylaniline);
N-(4-fluorophenyl)glycine;
L-4-Fluorophenylglycine;
6-hydroxy-5-nitrosonaphthalene-2-sulfonic acid - iron (3:1);
5-nitroso-6-oxidonaphthalene-2-sulfonate;
2-naphthal

英文名称：: b-D-Glucopyranoside, (3b)-solanid-5-en-3-yl O-6-deoxy-a-L-mannopyranosyl-(1®2)-O-[6-deoxy-a-L-mannopyranosyl-(1®4)]-

英文别名：: α-CHACONINE;
CHACONINE;
CHACONINE,A;
A-CHACONINE WITH TLC;
A-CHACONINE;
A-CHACONINE FROM POTATO SPROUTS;
ALPA-CHACONINE

CAS No.：: 20562-03-2

分子式：: C₄₅H₇₃NO₁₄

分子量：: 852.0594

精确分子量：: 851.50300

PSA：: 220.46000

InChI：: InChI=1/C45H73NO14/c1-19-7-10-28-20(2)31-29(46(28)17-19)16-27-25-9-8-23-15-24(11-13-44(23,5)26(25)12-14-45(27,31)6)57-43-40(60-42-37(53)35(51)33(49)22(4)56-42)38(54)39(30(18-47)58-43)59-41-36(52)34(50)32(48)21(3)55-41/h8,19-22,24-43,47-54H,7,9-18H2,1-6H3/

危险品标志：: Xn

风险术语：: 63

安全术语：: Poison by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects.

分子结构式：

SDS：: 查看

卡茄碱物化性质

密度：: 1.37 g/cm3
熔点：: 228-236ºC
折射率：: 1.621
存储条件/存储方法：: 库房低温通风干燥,与食品原料分开存放

卡茄碱安全信息

包装等级：: III
风险类别：: 6.1(b)
危险类别码：: R63
危险标志：: Xn: Harmful;

卡茄碱毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FL6700000

CHEMICAL NAME :: alpha-Chaconine

CAS REGISTRY NUMBER :: 20562-03-2

BEILSTEIN REFERENCE NO. :: 0077396

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C45-H73-N-O14

MOLECULAR WEIGHT :: 852.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg/8D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg/2D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 40 mg/kg

SEX/DURATION :: female 5-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 20 mg/kg

SEX/DURATION :: female 5-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 165 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg/3D (Continuous)

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 33,191,1995 *** REVIEWS *** TOXICOLOGY REVIEW FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,61,1979