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夸屈硅烷 基本信息
- 中文名称：
- 夸屈硅烷
- 中文别名：
- 夸屈硅烷;
二苯硅烷;
夸状西兰;
夸单硅蓝;
5-fluoro-2-methylbenzoate;
2-Methyl-5-fluorobenzoic acid;
5-fluoro-2-methylbenzoic acid;
N-Methyl bis(2,4-Xylyliminomethyl)amine;
N'-(2,4-dimethylphenyl)-N-{(E)-[(2,4-dimethylphenyl)imino]methyl}-N-methylimidoformamide (non-preferred name);
Amitraz;
PROMIDON;
N-(3,5-dichlorophenyl)-1,2-dimethylcyclopropane-1,2-dicarboximide;
3-(3,5-dichlorophenyl)-1,5-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione;
Procymidone;
TIMTEC-BB SBB004207
- 英文名称：
- Cyclotetrasiloxane,2,2,4,6,6,8-hexamethyl-4,8-diphenyl-, cis-
- 英文别名：
- 2,2,4,6,6,8-hexamethyl-4,8-diphenyl-1,3,5,7,2,4,6,8-tetraoxatetra silocane;
Thiocyanic acid,4-methyl-2,6-bis(methylamino)-3,5-pyridinediyl ester;
2,6-cis-diphenylhexamethylcyclotetrasiloxane;
2,6-Bis-methylamino-4-methyl-3,5-dithiocyanato-pyridin
- CAS No.：
- 33204-76-1
- 分 子 式：
- C18H28O4Si4
- 分 子 量：
- 420.82
- 精确分子量：
- 420.10600
- PSA：
- 36.92000
- EINECS：
- 251-406-1
- InChI：
- InChI=1/C18H28O4Si4/c1-23(2)19-25(5,17-13-9-7-10-14-17)21-24(3,4)22-26(6,20-23)18-15-11-8-12-16-18/h7-16H,1-6H3/t25-,26+
- 分子结构式：
-
- SDS：
- 查看
夸屈硅烷 物化性质
- 密度：
- 1.06 g/cm3
- 熔点：
- 41ºC
- 沸点：
- 353.9ºC at 760 mmHg
- 闪点：
- 146ºC
- 折射率：
- 1.513
夸屈硅烷 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GZ4390000
- CHEMICAL NAME :
- Cyclotetrasiloxane, 2,6-diphenylhexamethyl-, Z-
- CAS REGISTRY NUMBER :
- 33204-76-1
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 18
- MOLECULAR FORMULA :
- C18-H28-O4-Si4
- MOLECULAR WEIGHT :
- 420.82
- WISWESSER LINE NOTATION :
- T8-SI-O-SI-O-SI-O-SI-OJ A1 A1 C1 CR& E1 E1 F1 FR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTSAI Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1947-
Volume(issue)/page/year: 36(3),93,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTSAI Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1947-
Volume(issue)/page/year: 36(3),93,1975
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 300 ug/kg
- SEX/DURATION :
- female 3 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
21,68,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 1 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W.
Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:
7,260,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3 mg/kg
- SEX/DURATION :
- female 1 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W.
Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:
7,260,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 10 mg/kg
- SEX/DURATION :
- female 5 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W.
Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:
7,260,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 7 mg/kg
- SEX/DURATION :
- male 7 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
21,55,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 231 mg/kg
- SEX/DURATION :
- male 7 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
21,80,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 3 mg/kg
- SEX/DURATION :
- female 3 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
21,68,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 210 mg/kg
- SEX/DURATION :
- male 21 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
21,55,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 10 gm/kg
- SEX/DURATION :
- male 40 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
Reproductive - Paternal Effects - other effects on male
- REFERENCE :
- APTSAI Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1947-
Volume(issue)/page/year: 36(3),93,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 400 mg/kg
- SEX/DURATION :
- male 40 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
- REFERENCE :
- APTSAI Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1947-
Volume(issue)/page/year: 36(3),93,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 400 mg/kg
- SEX/DURATION :
- male 40 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
- REFERENCE :
- APTSAI Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1947-
Volume(issue)/page/year: 31(1),17,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 28 mg/kg
- SEX/DURATION :
- male 28 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
- REFERENCE :
- APTSAI Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1947-
Volume(issue)/page/year: 36(3),81,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 280 mg/kg
- SEX/DURATION :
- male 28 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
- REFERENCE :
- APTSAI Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1947-
Volume(issue)/page/year: 36(3),81,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 4 mg/kg
- SEX/DURATION :
- male 2 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 31,517,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1800 ug/kg
- SEX/DURATION :
- male 18 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
- REFERENCE :
- IJANDP International Journal of Andrology. (Scriptor Publisher ApS, 15
Gasvaerksvej, DK-1656 Copenhagen V, Denmark) V.1- 1978-
Volume(issue)/page/year: 1,378,1978
