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基本信息
- 中文名称：
-
- 中文别名：
- Phenol,4-[(7-chloro-4-quinolinyl)amino]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:2)
- 英文名称：
- Phenol,4-[(7-chloro-4-quinolinyl)amino]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:2)
- 英文别名：
- Phenol,4-[(7-chloro-4-quinolinyl)amino]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:2);
4-(7-Chlor-chinolyl-(4)-amino)-2-pyrrolidinomethyl-phenol-dihydrochlorid;
1-Naphthol,4-((7-chloro-4-quinolyl)amino)-2-((diethylamino)methyl)-5,6,7,8-tetrahydro;
4-(7-chloro-quinolin-4-ylamino)-2-diethylaminomethyl-5,6,7,8-tetrahydro-naphthalen-1-ol;
1-Naphthalenol,4-((7-chloro-4-quinolinyl)amino)-2-((diethylamino)methyl)-5,6,7,8-tetrahydro;
4-(7-Chlor-4-chinolylamino)-2-diethylaminomethyl-5,6,7,8-tetrahydro-I-naphthol
- CAS No.：
- 10350-81-9
- 分 子 式：
- C20H20ClN3O.2ClH
- 分 子 量：
- 426.80
- 精确分子量：
- 389.10600
- PSA：
- 48.39000
- InChI：
- The Key: HPGVLACNAKEYGS-UHFFFAOYSA-N
- 安全术语：
- Poison by intravenous route. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
- 分子结构式：
-
- SDS：
- 查看
物化性质
- 密度：
- 1.351g/cm3
- 沸点：
- 498.1ºC at 760mmHg
- 闪点：
- 255.1ºC
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GO7350000
- CHEMICAL NAME :
- o-Cresol,
4-((7-chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-,
dihydrochloride
- CAS REGISTRY NUMBER :
- 10350-81-9
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C20-H20-Cl-N3-O.2Cl-H
- MOLECULAR WEIGHT :
- 426.80
- WISWESSER LINE NOTATION :
- T66 BNJ IG EMR DQ C1- AT5NTJ &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 410 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 34 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 580 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- AJTHAB American Journal of Tropical Medicine and Hygiene. (Allen Press,
1041 New Hampshire St., Lawrence, KS 66044) V.1- 1952-
Volume(issue)/page/year: 6,987,1957
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 36876 mg/kg/12W-C
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - dehydration
Related to Chronic Data - death
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1320 mg/kg/2W-I
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - nausea or vomiting
Related to Chronic Data - death
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 120 mg/kg/16D-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 8,450,1958
